Graduate Immunology (BGGN 225)
Fall 2007

Course Coordinator: Kees Murre
Telephone: 534-8796
cmurre@ucsd.edu

Tuesdays and Thursdays: 1-3 pm
Location: NSB 4211

Components of the Immune System
Sept. 27 Kees Murre

Stem Cells

Oct. 2
Kerri Mowen Types of lymphocytes and antigen presenting cells
Organization of lymphoid system
Description of lymphoid organs
Lymphocyte trafficking
Oct. 4 Steve Schoenberger

Biology of antigen presentation
Dendritic cells, macrophages, B cells
Oct. 9 Kees Murre B and T lineage development

Discussion
Rossi et.al. (2005)
Antibody diversity

Oct. 11

Ann Feeney

Antigen receptors in the adaptive immune system
The generation of lymphocyte antigen receptors
Oct. 16 Kees Murre Class switch recombination
Somatic hypermutation
Development and survival of lymphocytes

Oct. 18

 David Nemazee

Positive and negative selection in T and B cell development

Baldwin et. al.

Antigen presentation and MHC
Oct. 23 Steve Schoenberger

Biology of antigen presentation
Dendritic cells, macrophages, B cells


Discussion
Heath & Carbone NRI
Liu et al JEM
Antigen Processing

Oct. 25

Mitch Kronenberg

MHC molecules and antigen processing/presentation in class I and class II systems

Discussion
Shastri review
Serwold / Shastri
T cell mediated immunity
Oct. 30 Steve Schoenberger

Effector T cells
T cell mediated cytotoxicity


Discussion
Barchett et al.
Immune Memory
Nov. 1 Steve Schoenberger

Survival and maturation of lymphocytes in peripheral lymphoid tissues
Immune memory and its persistence

Discussion
Hawiger
Transcriptional control of lymphocyte development
Nov. 6
Kees Murre

Signaling and transcriptional regulation in lymphocyte development
B cell activation by helper T cells
Distinct isotype functions
Fc receptor as signaling molecules
Tumor Immunology
Nov. 8 Mauricio Zanetti

 
Homeostasis

Nov. 13

Ananda Goldrath

Homeostatic proliferation and survival

Discussion

Kaja Murali-Krishna et al.

Innate Immunity
Nov. 15 Mitch Kronenberg

Complement and the innate immune system
Receptors of the innate immune system
Innate response to infection


Discussion
Akira
Beutler

Cytokine Mediated Signaling
Nov. 27 Carl Ware

Cytokines and cytokine receptors
TNF mediated signaling


Discussion
Cheung et al PNAS
Human auto immune syndromes
Nov. 29 Maripat Corr Introduction to human auto-immunity
Dec. 4 Maripat Corr

Human auto immunity

Discussion
Regulation in the immune system
Dec. 6 Mathias von Herrath

Co-stimulation and anti-costimulation
Regulatory T cells and cytokine polarization