Structural Biochemistry |
BIBC100 |
Dr. Montal |
Spring 2007 |
06.07.07 |
The review session is this Friday, June 8th from 7:00-9:00pm in CSB 001. Rachel will have extra office hours Friday morning from 10:00am-12noon in the Biomedical Library (BML). |
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COURSE SCHEDULE AND READING
| DATE | TOPIC | BRANDEN & TOOZE CHAPTER | ASSIGNED PAPER | BUEHLER'S READER CHAPTER |
April |
STRUCTURAL PRINCIPLES | |||
3 Tues |
Basics | 1 |
1.1 |
|
5 Thurs |
Exploring Proteins | 2 |
1.2 |
|
10 Tues |
Motifs | 3,4 |
1.3 |
|
12 Thurs |
Motifs | 5 |
1.3 |
|
17 Tues |
DNA/RNA | 7 |
1.4 |
|
19 Thurs |
NMR/X-Ray | 18 |
1.8 |
|
24 Tues |
NMR/X-Ray | 18 |
1.8 |
|
| RECOGNITION | ||||
26 Thurs |
Protein-DNA | 8,10 |
3.2 |
|
May |
||||
1 Tues |
Immune System | 15 |
3.6 |
|
3 Thurs |
MIDTERM IN CLASS |
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| ENERGY & SIGNAL TRANSDUCTION | ||||
8 Tues |
Membranes | 12 |
1.7 |
|
10 Thurs |
Membrane Proteins | 12 |
2.5 |
|
15 Tues |
Channels | 12 |
2.4 |
|
17 Thurs |
Receptors | 13 |
3.7 |
|
22 Tues |
Receptors | 13 |
3.7 |
|
| DYNAMICS | ||||
24 Thurs |
Ca^2+ and Oxygen Binding | 3 |
2.2 |
|
| CATALYSIS | ||||
29 Tues |
Proteases | 11 |
2.1 |
|
31 Thurs |
Proteases | 11 |
2.1 |
|
June |
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| FOLDING AND DESIGN | ||||
5 Tues |
Folding and Design | 6
|
2.6 |
|
7 Thurs |
Folding and Design | 17 |
2.7 |
|
JUNE 11 |
MONDAY 8:00AM - 11:00AM |
FINAL EXAM |
Textbooks (required) |
Introduction to Protein Structure. C. Branden and J. Tooze, 2nd Edition. Garland Publishing Co., NY 1999. |
| Kinemage Supplement to Branden and Tooze J.S. Richardson and D.C. Richardson Garland Publishing Co., NY |
|
Reader: |
Structural Biochemistry, 2nd Edition. Lukax Buehler Wiley Wiley Custom Services, 2002. |
Useful Websites: |
http://www.ncbi.nlm.nih.gov/gquery/gquery.fcgi http://www.biology.ucsd.edu/classes/bibc100.SP07 |
| ASSIGNED PAPERS - Synchronized with the syllabus | |
| From SCIENCE Vol. 286, © October 8, 1999: pp. 255-260 "Structural Changes in Bacteriorhodopsin During Ion Transport at 2 Angstrom Resolution", by Luecke, Schobert, Richter, et al. | |
| From NATURE Vol. 423, © May 2003: pp. 33-41 "X-ray Structure of a Voltage-Dependent K + Channel" by Jiang, Lee, Chen, et al. | |
| From NATURE Vol. 423, © June 26, 2003: pp. 949-955 "Structure and Gating Mechanism of the Acetycholine Receptor Pore" by Miyazawa, Fujiyoshi, Unwin. | |
| From NATURE Vol. 427, © January 1, 2004: pp. 36-44 "X-ray Structure of a Protein-conducting Channel" by Vandenberg, et al. | |
| From SCIENCE Vol. 302, © November 21, 2003: pp. 1364-1368 "Design of a Novel Globular Protein Fold with Atomic-Level Accuracy". pp. 1347-1348 "Learning to Speak the language of Proteins" by Kuhlman, Dantas, Ireton, et al. |
SECTIONS & OFFICE HOURS
| DAY & TIME | LOCATION | TA |
| Friday 2:00-3:00pm Friday 3:00-4:00pm |
Center 220 Center 220 |
Matthew Fradkin mfradkin@ucsd.edu Office Hours: Friday 1:00-2:00pm Leichtag Building |
| Tuesday 5:00-6:00pm | Center 218 | Rachel Newman rdnewman@ucsd.edu Office Hours: Tuesday 10:00-11:00am Biomedical Library |
| Monday 4:00-5:00pm | Center 218 | Christopher Rafie crafie@ucsd.edu Office Hours: Monday 8:00-9:00am Cafe Roma |
| Monday 3:00-4:00pm | Center 218 | Artour Torossian atorossi@ucsd.edu Office Hours: Monday 4:00-4:50pm Science and Engineering Library |
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LECTURES
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