Welcome to Structural Biochemistry at the Biology Department at UCSD taught by Dr. Lukas Buehler. This class is an introduction to various aspects of the structure and function of biologically important macromolecules. These include proteins, nucleic acids, polysaccharides, and lipids. The course is divided into 3 major parts (building blocks, structure-function relationship, cellular substructures) each concluding with a closed book examination. To guide you through the lecture, a custom reader is available at the Price Center Bookstore. This reader is an outline of the lecture and is meant as a guideline, not a substitute, for the textbook.

BIBC 100 - Summer 2007

MTWTh 5-6:20 PM York 2622

Instructor: Dr. Lukas Buehler
TAs Samantha Cheung
Walter Le
Phu Tran
Biraj Shah
Amiee Ho
   
Grades Midterm 1    30%
Midterm 2    30%
Final Exam  40 %
   
Syllabus Course calendar
(with links to lecture slides in pdf format)
Policy information

Updates

Key to final exam
Exams are now available for pickup at York 4070 (lobby)

Grade ranges:

for final exam only (out of 80 max):
A 70
B 60
C 50
D 40

total score (out of 200 max)
A 170
B 145
C 120
D 95

Office hours during second session are MW 4-4:50pm
 
Study Guides

Study Guide 3 (final exam)
The Final Exam is not cumulative and covers serine proteases, ion channels, oxygen and calcium binding, molecular dynamics, protein folding and structure prediction and design. Sample Final Exam from 2006.

Study Guide 2
Second midterm will cover nucleic acid structures, polysaccharides, and membrane lipids. Sample midterm exam from 2006

Study Guide 1
First midterm will cover solubility, amino acids, peptide and protein structures. Sample midterm exam from 2006.

Exam Keys

Key for midterm 2
Grade ranges A 52-60; B 45-51; C 38-44; D 31-37
Regrade requests are no longer accepted

Midterm 1 key
Grade ranges: A 48-60; B 40-47; C 32-39; D 24-31
Regrade requests are no longer accepted
   
Text Books

Structural Biochemistry, 2nd
by Lukas K. Buehler
J.Wiley & Sons (Custom reader)

Fundamentals of Biochemistry, 2nd
by Voet, Voet and Pratt
J.Wiley & Sons, 2005
(find it at the BML Reserves shelf)


Internet		  

Images of Biological Macromolecules
Protein Data Bank (PDB
ENTREZ Structure (NCBI)

View an animation of the complete ATP-synthase function.
Rotation of isolated ATP-synthase with fluorescence labeled actin marker: original data and animation of purified and reconstiuted F1 portion (synthase domain)

Please send any questions or comments regarding this class to Lukas Buehler
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