BIBC 110, Summer Session II, 2007, 8/6-9/8
MW 5:00 - 7:50PM York Hall 4080A
Instructor: Dr. Lukas Buehler
OH: York Hall 4070 MW 4-4:50PM

Teaching Assistant: Mohammad Maktabi

Course Outline

This course introduces the principles of physical biochemistry and its applications to the study of macromolecular structure and function. The course covers thermodynamic principles in understanding behavior of macromolecules such as solubility and enzymatic activity. Structure determination techniques are presented to show the experimental approaches addressing structure function relationship of proteins at different levels of resolutions, both conformational and in time. Finally, surface active molecules and biological membranes are discussed including chemical equilibrium phenomena across membranes, self assembly properties of membranes and channel forming peptides and transport processes vital for the function of biological activity in the brain.

Detailed Course Calendar / Syllabus

Course requirements: Grade
Quizzes (four, 15% each) 60%
Proposal 5%
Report 25%
Presentation 10%

Contact me at lbuehler@ucsd.edu with any questions.

Updates

Quiz 4 can be found at York 3080

Grade ranges

Quiz 4 Class grade#
24 A
20 B
16 C
12 D
 175 A
160 B
145 C
130 D
(out of 30) (out of 200 points *)

#All quizzes combined weigh 60%
Report (inlcuding proposal and presentation) 40%

*To count points:
Each quiz 30p max (total 120 max)
Proposal 10p
Presentation 20p
Report
50p for A
46p for A-
42p for B+
38p for B

 

Key for quiz 4; graded exams and reports can be picked up from York 4070 starting Tue 9/11; for questions about the class grade, please email Lbuehler@ucsd.edu to discuss or to set an appointment.

Quiz 3 grade ranges:
A 24-30
B 20-23
C 16-19
D 12-15

Exam 1: study guide, sample exam, key1
Exam 2: study guide, sample exam, key2
Exam 3: study guide, sample exam, key3
Exam 4: study guide, sample exam, key4

Group presentations

How-to-guide for presentations and report writing

Group listings

 
Text Book

Kensal E van Holde, Curtis Johnson, Pui Shing Ho
Principles of Physical Biochemistry, 2/E
ISBN: 0-13-046427-9; Publisher: Prentice Hall; Copyright: 2006

On-line Resources (Biophysical Society)
Biophysical Techniques

Thermodynamics, Hydrodynamic methods, Spectroscopy, Single Molecule Techniques
Molecular Structure & Behavior

Structure of membrane proteins, Lipids & Membranes
Biophysical Mechanisms

Electrical behavior of cells, Energy Transduction in Membranes, Protein Function, Membrane Behavior

Calbiochem Detegent Handbook (via EMD Biosciences = Merck Germany (not US))

Please send any questions or comments regarding this class to Lukas Buehler
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