CELLULAR NEUROBIOLOGY

BIPN 140 Winter 2008

SYLLABUS

 

Professors:              Massimo Scanziani & Anirvan Ghosh

Times:                       Tuesdays & Thursdays, 5:00 - 6:20 P.M.

Location:                   Center 212

Required Text:         Neuroscience, Purves et al. (3rd or 4th edition, Sinauer Associates Publishers)

 

 

Announcements:

 

¤      Final Exam tonight, Thursday March 20th, 7-9pm in 212 Center Hall

 

¤      Problem Set 8 Questions and Answers Posted

 

¤      Students voted to keep the grading scheme 50% midterm, 50% final exam, with 10 points added to everyoneÕs score after the curve.

 

 

 

Date

 

 

Lecture

 

 

Title

 

 

Purves Chapter

 

Additional Required Reading

Problem

Set

Instructor

 

 

Lecture 1

 

 

8-Jan-08
 
 

Cellular Components of the Nervous System

 

1

 

 

 

 

MS

 

 

Lecture 2

 

 

 

10-Jan-08

 

 

 

Mebrane potential

 

 

 

2

 

 

 

Chap2 Dynamical Systems in Neuroscience

 

Problem Set 1 Questions

Answers

MS

 

 

 

Lecture 3

 

 

15-Jan-08

 

 

 

 

The Action Potential

 

 

 

2,3

 

 

 

 

 

MS

 

 

 

Lecture 4

 

 

 

17-Jan-08

 

 

 

Ion Channels

 

 

 

4

 

 

 

 

Dynam Systems in Neurosci contÕd

 

 

Problem Set 2 Questions

Answers

MS

 

 

 

Lecture 5

 

 

22-Jan-08

 

 

Combination of Currents

 

 

4

 

 

 

 

 

MS

 

 

Lecture 6

 

 

 

24-Jan-08

 

 

 

Combination of Currents

 

 

 

 

4

 

 

 

 

 

Problem Set 3 Questions

Answers

MS

 

 

 

 

Lecture 7

 

 

 

29-Jan-08

 

 

 

Synaptic  Release of Neurotransmitter I

 

 

5

 

 

 

Voltage Sensors

 

 

MS

 

 

 

Lecture 8

 

 

 

 

 

31-Jan-08

 

 

 

 

 

Synaptic  Release of Neurotransmitter II

 



 

5

 

 

 

 

 

Quantal Analysis

Otto LoewiÕs dream (ppt)

 

Problem Set 4 Questions

Answers

 

MS

 

 

 

 

Lecture 9

 

 

5-Feb-08

 

 

Transmitters and their Receptors I

 

 

 

6

 

 

 

 

 

MS

 

 

Lecture 10

 

 

7-Feb-08

 

 

Transmitters and their Receptors II

 

6,7

 

 

 

 

MS

 

 

Midterm

 

12-Feb-08

 

 

 

 

Midterm 2006

Midterm 2007

 

 

MS

 

 

Lecture 11

 

 

 

14-Feb-08

 

 

Synaptic Integration

 

 

6,7

 

 

 

 

MS

 

 

 

Lecture 12

 

19-Feb-08

 

Neuromodulation

 

5

 

 

 

 

 

MS

 

Lecture 13

 

21-Feb-08

 

Synaptic Plasticity

 

24

 

 

Problem Set 5 Questions

Answers

MS

 

Lecture 14

 

26-Feb-08

 

Neural Induction and Patterning

 

21

 

 

 

 

AG

 

 

Lecture 15

 

28-Feb-08

 

Differentiation

 

21

 

 

 

Problem Set 6 Questions

Answers

AG

 

Lecture 16

 

4-Mar-08

 

Axonal and Dendritic Development

 

22

 

 

 

AG

 

Lecture 17

 

6-Mar-08

 

Axon Guidance

 

22

 

 

Problem Set 7 Questions

Answers

AG

 

Lecture 18

 

11-Mar-08

 

Synapse Formation

 

22

 

 

 

AG

 

Lecture 19

 

13-Mar-08

 

Experience-dependent plasticity

 

23

 

 

Problem Set 8 Questions

Answers

AG

 

Finals

20-Mar-08

 

 

 

 

 

 

Drop without W:

Friday, February 01, 2008

Drop with a W

Friday, March 07, 2008

 

Midterm:

Tuesday, February 12, 2008

Location:

Center 212

Time: 5:00-6:20 pm

Finals:

Thursday, March 20, 2008

Location:

TBA

Time: 7 -10 pm

 

 

Problem Sets:          Problem sets will be posted on the class website almost every week.  They will cover the previous weekÕs material.  They are for practice only:  they will not be graded, but you may be called upon in section to answer them.  Answers will be available on the website the week after they are handed out.

 

Sections: Start the week of January 14th. Attend the one of your choice.

Mondays 4:00-4:50 pm (HK)

Location:

HSS 1305

Mondays 5:00-5:50 pm (BA)

Location:

HSS 1305

Wednesdays 8:00-8:50 am (BA) 

Location:

Center 217B

Wednesdays 6:00-6:50 pm (DW)

Location:

Center 220

 

 

Pre-Exam Review Sections:

Midterm

Friday, February 08, 2008

Location:

Pacific Hall 3500

Time: 5:30-7:30 pm

Final

Tuesday, March 18, 2008

Location:

Pacific Hall 3500

Time: 5:30-7:30 pm

 

 

Grading:                     Midterm               50 %

                                    Final Exam           50 %

                                    Grading is on a curve.

 

 

Supplemental Texts: Neuroscience, Bear, Connors & Paradiso  

                                     Principles of Neural Science, Kandel and Schwartz

                                     Neurobiology, Shepherd

                                     Ionic Channels of Excitable Membranes, Hille

                                    From Neuron to Brain, Nicholls, Martin and Wallace (3rd edition)

 

Lecture Outlines:  Generally available from class website: 
                                                                            http://www.biology.ucsd.edu/classes/bipn140.WI08/

 

General Information

 

InstructorS:          Massimo Scanziani, CMG 203, massimo@ucsd.edu, 822 3839;

            Anirvan Ghosh, Pacific Hall 1123, aghosh@ucsd.edu, 822 4142.

 

Instructor Office Hours:

 

 

Massimo Scanziani

2:00 pm, Tuesdays

Location:

CMG 203

Anirvan Ghosh

2:00 pm, Tuesdays

Location:

Pacific Hall 1123

 

Teaching Assistants

Office Hours

Location

e -mail

Bassam Atallah

12:00 am, Mondays

 CMG 213

bassam.atallah@gmail.com

Diane Whitmer

 6:20-6:50pm Tues-Thurs

 Center 212

dwhitmer@biomail.ucsd.edu

Hussain Karimi

 6:00 pm Mondays

 Clics 253

hkarimi@ucsd.edu

 

Handouts: This Syllabus and General Information is the only handout.  Problem Sets will be available from the class website. Overheads will usually be available on the class website as well. 

 

Problem sets: These consist of sets of questions that will help you evaluate your understanding of the material covered in the lectures and the reading.  They are similar to questions you will have to answer on exams. To get the most out of them, treat them like exams.  In the past there has been an excellent correlation between those who worked through the problem sets and those who received high grades in the course.  They will not be graded, but will be discussed in section. The answers will be available on the class website after the week in which they are discussed.

 

Recitation sections: Sections will meet starting the second week of the quarter. The sections are useful opportunities to go over material that has been presented in the lectures and in the reading.  They are also valuable because the problem sets and their solutions will be discussed.

 

Exams: The grade in the course depends on the midterm exam and a final exam. The exams will consist of short essays and problems. The Midterm will cover lectures 1 to 10. The final exam will be comprehensive, covering the whole course. The exams will cover material from lectures, assigned reading, and problem sets. The lectures are important since they highlight matters of particular significance and discuss issues that may be complex. The text is important since this reading provides further background and the instructor does not cover all of the material in lecture.  The problem sets are important since they provide excellent practice in working out exam questions and some of the questions on the exams will be drawn from the problem sets.