April 3rd
Class Organization & Introduction to reading articles on cell architecture.
Review: Dawes-Hoang and Wieschaus (2001) Cell and Developmental Biology — A Shared Past, an Intertwined Future. Dev Cell, 1: 27-36.
Review: Essays by Bill Sullivan and Doug Kellogg, “The Salvation of Doug” and “The Demise of Bill”
April 10th
Maintaining cell polarity: restriction of membrane domains in epithelial cells
Primary Article: Bilder and Perrimon (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature, 403: 676-680.
Related article: Bilder, Li and Perrimon (2000) Cooperative Regulation of Cell Polarity and Growth by Drosophila Tumor Suppressors. Science, 289: 113-116.
Review: Nelson (2003) Adaptation of core mechanisms to generate cell polarity. Nature 422: 766-774.
April 17th
Establishing cell polarity: polarized cell protrusion in wound healing response
Primary Article: Osmani, Vitale, Borg and Etienne-Manneville (2006) Scrib Controls Cdc42 Localization and Activity to Promote Cell Polarization during Astrocyte Migration. Current Biology, 16: 2395-2405.
Related article: Etienne-Manneville and Hall (2001) Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKC. Cell, 106: 489-498.
Review: Fukata, Nakagawa and Kaibuchi(2003) Roles of Rho-family GTPases in cell polarisation and directional migration. Curr. Opin. Cell Biol., 15: 590-597.
April 24th
Polarity in motion: designation of a leading edge in chemotaxis
Primary Article: Funamoto, Mieli, Lee, Parry and Firtel (2002) Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis. Cell, 109: 611-623.
Related articles: Iijima and Devreotes (2002) Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients. Cell, 109: 599-610
Review: Comer and Parent (2002) PI 3-Kinases and PTEN: How Opposites Chemoattract. Cell, 109: 541-544.
Review: Ridley et al. (2003) Cell Migration: Integrating Signals from Front to Back. Science, 302: 1704-1709.
May 1st
Dynamic control of cell shape: Rho GTPase roles in immune cell chemotaxis
Primary Article: Stramer et al. (2005) Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration. J. Cell Biology, 168: 567-573.
Related article: Wood, Faria and Jacinto (2006) Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J Cell Bio, 173: 405-416.
Review: Etienne-Manneville and Hall (2002) Rho GTPases in cell biology. Nature, 420: 629-635.
May 8th
Pathogen control of host cell shape: bacterial GTPase activity to hijack host
Primary Article: Alto et al. (2006) Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions. Cell, 124: 133-145.
Review: Hayward and Koronakis (2006) Pathogens reWritE Rho’s Rules. Cell, 120: 15-17.
Review: Galan and Collmer (1999) Type III Secretion Machines: Bacterial Devices for Protein Delivery into Host Cells. Science, 284: 1322-1328.
May 15th
Specialized cell outgrowths: cilia formation and human diseases
Primary Article: Avidor-Reiss et al. (2004) Decoding Cilia Function: Defining Specialized Genes Required for Compartmentalized Cilia Biogenesis. Cell, 117: 527-539.
Related article: Li et al. (2004) Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene. Cell, 117: 541-552.
Review: Davis, Brueckner and Katsanis (2006) The Emerging Complexity of the Vertebrate Cilium: New Functional Roles for an Ancient OrganelleDev Cell, 11: 9-19.
Review: Singla and Reiter (2006) The Primary Cilium as the Cell’s Antenna: Signaling at a Sensory Organelle. Science, 313: 629-633.
May 22nd
Contractility in cell shape changes: localized control of myosin in gastrulation
Primary Article: Dawes-Hoang et al. (2005) folded gastrulation, cell shape change and the control of myosin localization. Dev, 132: 4165-4178.
Mini-review: Schuldt (2005) Fog shapes up myosin for gastrulation. Nat. Cell Bio, 7: 935.
Review: Leptin (1999) Gastrulation in Drosophila: the logic and the cellular mechanisms. EMBO J, 18: 3187-3192.
Review: Reichl, Effler and Robinson (2005) The stress and strain of cytokinesis. Trends Cell Biol., 15: 200-206.
May 29th
Cell-cell signals and cell shape: cues for polarity disassembly and metastasis
Primary Article: Ozdamar et al. (2005) Regulation of the Polarity Protein Par6 by TGFb Receptors Controls Epithelial Cell Plasticity. Science, 307: 1603-1609.
Review: Thiery (2003) Epithelial–mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol., 15: 740-746.
Review: Thiery and Huang (2005) Linking Epithelial-Mesenchymal Transition to the Well-Known Polarity Protein Par6. Dev Cell, 8: 456-458.
