Structural Biochemistry - BIBC 100 - Fall 2000
Lecture: Tu/Th 3:55-5:15PM
WLH 2001
Lukas Buehler, Bonner Hall 2402 |
Office Hours: Tuesday, 2-3 PM
Tel 822-1311, lbuehler@ucsd.edu |
| Week |
Date |
Topic: Class Reader |
B&T |
Lehninger |
V&V |
|
|
I. Building Principles of Macromolecules |
|
|
|
| 1 |
Th Sep 21 |
Aqueous solutions, Hydrophobic effect |
- |
4 |
1-3,7 |
| 2 |
T Sep 26 |
Protein structure I: Amino acids |
1 |
5 |
4 |
|
Th Sep 28 |
Protein Structure II: a -helix;
b
-sheet, turns |
2,3 |
6 |
7 |
| 3 |
T Oct 3 |
DNA structure; RNA structure |
7 |
10 |
26,28,30 |
|
Th Oct 5 |
Polysaccharides: Sugars |
- |
9 |
10 |
| 4 |
T Oct 10 |
Cell membrane: Lipids |
- |
11,12 |
11 |
|
Th Oct 12 |
Structure determination techniques |
18 |
6 |
7 |
| 5 |
T Oct 17 |
1. Midterm (during class) |
|
|
|
|
|
II. Structure - Function Relationship of Proteins |
|
|
|
|
Th Oct 19 |
Enzyme kinetics: Serine proteases |
11 |
8 |
12,14 |
| 6 |
T Oct 24 |
Ligand binding: Hemoglobin |
3 |
7 |
9,12,13 |
|
Th Oct 26 |
Metalloproteins, Pumps, Channels |
2,12 |
12 |
14,17,18 |
| 7 |
T Oct 31 |
Acetylcholine receptor; potassium channel |
12 |
13 |
11,18,34 |
|
Th Nov 2 |
Electron transport, Bacterial photosynthesis |
12 |
19 |
22 |
| 8 |
T Nov 7 |
Protein motion; Protein folding; Self-assembly |
3,6 |
6 |
7-9 |
|
Th Nov 9 |
2. Midterm (during class) |
|
|
|
|
|
III. The Structural Basis of Cellular Mechanisms |
|
|
|
|
T Nov 14 |
DNA binding proteins; transcription factors |
8-10 |
24,28 |
29,33 |
|
Th Nov 16 |
Cytoskeleton: molecular motors |
- |
27 |
7,34 |
|
T Nov 21 |
Glycoproteins, Lectins |
- |
9 |
10,21 |
|
Th Nov 23 |
Holiday |
- |
- |
- |
|
T Nov 28 |
Antibodies; cell surface proteins |
15 |
7 |
34 |
|
Th Nov 30 |
HIV host cell recognition |
- |
26 |
6,30,31 |
|
Th Dec 7 |
Final Exam 3-6 pm |
|
|
|
Note: Indicated chapters may contain only part of the required
material. Restrict reading to topics covered in class reader. Use textbook
indeces to find relevant sections, if necessary.
Textbooks:
"Introduction to Protein Structure", by Brandon&Tooze,
2nd 1998 (B&T)
"Class reader - Structural Biochemistry", L. Buehler
(University Bookstore)
others:
"Lehninger Principles of biochemistry", By Nelson, Cox,
3rd, 2000
"Biochemistry", by Voet and Voet, 2nd ed., 1995 (V&V)
"Biochemistry", by L. Stryer, 4th ed., 1995
"Essentials of Biochemistry", Voet&Voet, and Pratt
, 1998 |
Course requirements:
1. Midterm (part I): 30%
2. Midterm (part II): 30%
Final Exam (part III): 40% |
|