| Week |
Date |
Topic: Class Reader |
Lehninger |
|
|
I. Building Principles of Macromolecules |
|
| 1 |
Th Sep 26 |
Aqueous solutions, Hydrophobic effect |
1-4 |
| 2 |
T Oct 1 |
Protein structure I: Amino acids |
5 |
|
Th Oct 3 |
Protein Structure II: a -helix;
b
-sheet, turns |
6 |
| 3 |
T Oct 8 |
DNA structure |
10 |
|
Th Oct 10 |
RNA structure |
10 |
| 4 |
T Oct 15 |
Polysaccharides |
9 |
|
Th Oct 17 |
Cell membrane: Lipids |
11,12 |
| 5 |
T Oct 22 |
Structure determination techniques |
6 |
|
Th Oct 24 |
Midterm (during class) |
|
|
|
II. Structure - Function Relationship of Proteins |
|
| 6 |
T Oct 29 |
Enzyme kinetics: Serine proteases |
8 |
|
Th Oct 31 |
Ligand binding: Hemoglobin |
7 |
| 7 |
T Nov 5 |
Metalloproteins, Pumps, Channels |
12,13 |
|
Th Nov 7 |
Acetylcholine receptor; potassium channel |
13 |
| 8 |
T Nov 12 |
Electron transport, Bacterial photosynthesis |
19 |
|
Th Nov 14 |
Protein motion; Protein folding; Self-assembly |
6 |
|
|
III. The Structural Basis of Cellular Mechanisms |
|
| 9 |
T Nov 19 |
DNA binding proteins; transcription factors |
24,28 |
|
Th Nov 21 |
Cytoskeleton: molecular motors |
2 |
| 10 |
T Nov 26 |
Glycoproteins, Lectins |
9, 27 |
|
Th Nov 28 |
Holiday |
|
| 11 |
T Dec 3 |
Antibodies; cell surface proteins |
7, 13 |
|
Th Dec 5 |
HIV host cell recognition |
12 |
| Final |
Tu Dec 10 |
Final Exam 7-10 pm |
|