BIBC 100                      STRUCTURAL BIOCHEMISTRY                SPRING 2003

 


LECTURE:              Tuesday and Thursday 8:00 – 9:20 A.M.

                              Price Theater

 

INSTRUCTOR:        M. Montal               (x40931)

                              Office Hours:           Tuesday 9:30 to 10:20 AM

                                                            Room 2140, Bonner Hall

                              Sutara Yu               ( x41654)

                              (Secretary)             Room 1226, Pacific Hall

 

WEEK

 

 

1

 

2

 

3

 

4

 

 

5

 

 

 

6

 

7

 

8

 

 

 

9

 

 

10

 

 

 

 

 

 

DATE

 

 

APRIL  Tues    1

            Thurs   3

            Tues    8

            Thurs 10

            Tues  15

            Thurs 17

            Tues  22

 

            Thurs 24

            Tues  29

MAY   Thurs   1

 

            Tues    6

            Thurs   8

            Tues  13

            Thurs 15

            Tues  20

 

            Thurs 22

 

            Tues  27

            Thur  29

 

JUNE   Tues   3

            Thurs  5

 

TOPIC

 

STRUCTURAL PRINCIPLES

Basics

Exploring Proteins

Motifs

Motifs

DNA/RNA

NMR/X-Ray

NMR/X-Ray

RECOGNITION

Protein-DNA

Immune System

MID-TERM IN CLASS

ENERGY & SIGNAL TRANSDUCTION

Membranes

Membrane Proteins

Channels

Receptors

Receptors                                         

DYNAMICS

Ca 2+ and Oxygen Binding

CATALYSIS

Proteases

Proteases

FOLDING AND DESIGN

Folding and Design

Folding and Design

TEXT REFERENCE

 

1

2

3,4

5

7

18

18

 

8,10

15

 

 

 

12

12

12

13

13

 

3

 

11

11

 

6

17

 

ASSIGNED PAPER

 

 

 

 

#1

 

 

 

 

#2

 

 

 

 

 

#3

 

 

 

 

#4

 

 

 

 

 

#5

 

 

FINAL EXAM  WEDNESDAY, JUNE 11  8:00 – 11:00 A.M.

 

 

 

 

BIBC 100 

SPRING 2003

 

Textbooks (required):         Introduction to Protein Structure.  C. Branden and J.Tooze, 2nd Edition.  Garland Publishing Co., NY 1999.

                             

Kinemage Supplement to Branden and Tooze

                                        J.S. Richardson and D.C. Richardson

                                        Garland Publishing Co., NY

 

Useful Websites:               http://www.ProteinStructure.com

                                        http://www.kenyon.edu/depts/bmb/chime/gallery.htm

 

Course Requirements:                                                                   GRADE

 

Midterm:       Thursday, May 1, during class                40%

Final:            Wednesday June 11, 8:00 – 11:00 A.M.  60%

 


ASSIGNED PAPERS – Synchronized with the syllabus

 

#1      de Vos, A.M., Ultsch, M., Kossiakoff, A.A. (1992).

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. 

Science 255:360-312

 

#2      Deisenhofer, J., Epp, O., Miki, K., Huber, R., Michel, H. (1985).

Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3A resolution.

Nature 318:618-624

 

#3      Unwin, N. (1995).

          Acetylcholine receptor channel image in the open state.

          Nature 373:37-43

 

#4      Milburn, M.V., Tong, L., de Vos, A.M., Brunger, A., Yamaizumi, Z., Nishimura, S., Kim, S.H. (1990).

Molecular switch for signal transduction: structural difference between active and inactive forms of proto-oncogenic ras proteins.

Science 247:939-945.

 

#5      Navia, M.A., Fitzgerald, P.M.D., McKeever, B.M., Leu, C.T., Heimbach, J.C., Herber, W.K., Sigal, I.S., Darke, P.L., Springer, J.P. (1989).

Three-dimensional structure of aspartylprotease from human immunodeficiency virus HIV-1.

          Nature 337:615-620
BIBC 100: STRUCTURAL BIOCHEMISTRY

 

GRADING INFORMATION:         Plus and minus grading will not be used

 

MIDTERM:             Grade Revisions:

                              Submit request to TA no later than May 8, 2003

                              No grade changes after May 15, 2003

                              NO EXCEPTIONS

 

FINAL:                    Grade Revisions:

Submit request to Professor or TA no later than    

June 18, 2003

No grade changes after June 23, 2003

NO EXCEPTIONS

                   


BIBC 100: Structural Biochemistry

 

Guidelines for Class Etiquette During Examination

 

1.     All writing instruments must contain non-erasable ink.  If students choose not to write in pen, they forfeit the opportunity for a future regrade.

 

2.     All books and handbags should be placed at the front or back section of the auditorium for the duration of the exam.

 

3.     Students should sit in alternating seats whenever possible.

 

4.     When time is called, anyone who is still writing will automatically receive a zero for that page.  THIS WILL BE STRICTLY ENFORCED.  Remain in your seat and hand your exam down the aisle.

 

 

 

UCSD policy on integrity of scholarship (UCSD catalog 99-00, pages 72-74) and Rules of academic dishonesty will be strictly enforced.