Course:     Structural Biochemistry, BIBC100
Lecture:     M/T/W/Th 5:00-6:20PM Center Hall 109
Instructor:  Lukas Buehler
Contact:    lbuehler@ucsd.edu
Week Date Topic (click on chapter title to get PDF file of slides)
Cox,Lehninger 
I. Building Principles of Macromolecules
1 M July 1 Aqueous solutions, Hydrophobic effect  (Intro PDF)
1-4
Tu July 2 Protein structure I: Amino acids
5 
W July 2 Protein Structure II: a -helix; b -sheet, turns
6
  Th July 4 Holiday
-
 2 M July 8 DNA and RNA structure
10
  Tu July 9 Monosaccharides; Polysaccharides
9
  W July 10 Lipids and membrane structure
11,12
Th July 11 Structure determination techniques
6
3  M July 15 Midterm (during class; 40% of grade)
Exam
II. Structure - Function Relationship of Proteins
  Tu July 16 Enzyme kinetics: Serine proteases
8
  W July 17 Ligand binding: Hemoglobin
7
Th July 18 Metalloproteins, Pumps, Channels
12,13
4  M July 22 Acetylcholine receptor; potassium channel
13
  Tu July 23 Electron transport, Bacterial photosynthesis
19
W July 24 Protein motion; Protein folding; Self-assembly
6
III. The Structural Basis of Cellular Mechanisms
Th July 25 Protein-DNA interaction; transcription factors
24,28
 5 M July 29 Cytoskeleton: molecular motors
2
  Tu July 30 Glycoproteins, Lectins
9,27
  W July 31 Antibodies; cell surface receptors; cadherins
7,13
Th August 1 HIV host cell recognition
12
  F August 2 Final Exam (5-7:50 PM, York 2722, new location; 60%)
 Exam
* Chapters indicated cover much more material than discussed during class. Please use the Class Reader as guide for topics covered. Use the text book selectively by looking up table of contents and keyword index. Figures from the text book will be used during lecture. This figures also indicated which sections in each chapter to focus on.

HOME