Syllabus - Structural Biochemistry BIBC 100 – Summer 05

Lecture  MW                               2:00p - 4:50p   CENTR 109
Makeup F          07/01/2005          2:00p - 4:50p   CENTR 109
Final      S          07/30/2005        11:30a - 2:30p    CENTR 109

Week

Day

Lecture topics
(click on topic link to get PDF file of slides used in lecture)

Reading *

Comments

1

M 6/27

Introduction
Aqueous solutions
Amino acids

1.3
2, 8.4
4

  
 

W 6/29

Protein secondary structure, motifs
X-ray and NMR techniques

7.1, 8

  
 

F 7/1

DNA and RNA structures

5, 29, 32

Makeup session

2

M 7/ 4

Holiday

--

  
 

W 7/6

Polysaccharides
Cell membranes

11
12

Quiz 1

3

M 7/ 11

Enzymes: Serine proteases
Binding: Hemoglobin
Metal binding proteins

13.2, 13.4
15.3
10, 15.1, 18.3

  
 

W 7/13

Ion channels, Selectivity
Electron transport

20, 12.3, 9.3
24.2

Midterm

4

M 7/18

Protein motion, folding, and stability

9, 20.2
8.4
34.4

  
 

W 7/20

Nucleosome structure
DNA binding proteins

34
31.3

  

5

M 7/25

Molecular motors
Glycoproteins, antibodies

20.3, 22.3
11.3

Quiz 2
 

W 7/27

Receptors
HIV and drug design

19.2, 19.3, 22.3
15.4

  
 

S 7/30

FINAL  11:30 – 2:30 PM

  

Final

Reading: Chapters from Voet & Voet, Biochemistry, 3rd ed, 2004; Many times only a part of a book chapter is covered; please refer to lecture notes, slides, and reader for the proper selection; required reading from Class Reader (Structural Biochemistry, Second edition by Lukas K. Buehler

Policies regarding exams and regrading

Regrading

Regrades for midterms will be allowed and have to be submitted no later than one week from the time you receive the graded exams. It is the responsibility of TAs grading a particular problem to make corrections or adjustments. You can submit a written request for more than one problem. Those requests will be regraded during a regrading session after the one week period allotted to submit a request.

Make up exams

Midterms are held during class time. Makeup exams are available for emergency reasons and conflicts with other assignments for which students have no control over the timing. For conflicts regarding the final exam and having more than two (=3) final exams within a 24-hour period, you need to contact your college administration to request make up exams. You should do this during the first week of class and as soon as you are aware of such clustering. There are no makeup finals if you (or some relatives) make travel arrangements before the end of the scheduled final exam.

Cheating

To avoid cheating problems, please write in pen and not pencil. If you make changes, mark them clearly (cross out) and do not erase and write over other words. A small number of exams will be photo copied (after grading and before students receive them) and compared with the submitted regrade request. Photocopies are done randomly and are not a systematic approach nor are they targeting any students in particular. Cheating will be reported to the Dean of your college.