Fall 2000
Syllabus * Sections * Office Hours * Web Reader
Welcome
to Metabolic Biochemistry at the Biology Department at the University of
California, San Diego for Fall Quarter 2000. This course is taught by
Dr.
Lukas Buehler.
The goal is to understand energy producing pathways (glycolysis, citric acid cycle, oxidative phosphorylation, photosynthesis, and fatty acid oxidation) and biosynthetic pathways (gluconeogenesis, glycogen synthesis, fatty acid synthesis, and amino acid and nucleic acid metabolism) including the metabolism of signalling molecules like neurotransmitters and steroid hormones. The course pays particular attention to human physiology, and the structural organization of pathways is discussed in terms of cellular location and compartmentalization, as well as co-ordination of pathways among different organs (metabolic integration). The importance of biological membranes for metabolic integration and regulation is addressed through discussions of transport systems for small metabolites as well as the central role of membrane biogenetic pathways in human lipid metabolism.
Updates
and exam keys
Key and grade information
Final exam distribution:
December 13-15, from 8:30-12:00 and 1:00-4:00
January 8-12, from 8:30-12:00 and 1:00-4:00
@ Pacific Hall, North Entrance
After January 12, exams can be obtained from Bonner Hall
2402, Tuesdays 10-12am.
There will be no office hours before the start of the
Winter quarter. If you have regrade requests or other matters to discuss,
please e-mail or leave a written request in my mailbox at York 3080C.
Use the study guide to prepare
for the second midterm
Use the study guide to prepare
for the first midterm.
study guide for final exam;
(see guide 2 for transport questions)
Key to 1. midterm and regrading
procedure
Key to 2. midterm
Textbooks:
Class Reader, available at University Bookstore
"Lehninger Principles of Biochemistry" Lehninger, Nelson, Cox, 3rd, 2000
You may also use:
"Biochemistry",
by L. Stryer, 4th ed., 1995
"Fundamentals
in Biochemistry" Voet, Voet and Pratt, 1998
"Biochemistry"
by Voet and Voet, 2nd ed., 1995
Course
requirements and Grade:
1. Midterm: 30% ( during class)
2. Midterm: 30% (during class)
Final Exam: 40% ( )
Teaching
Assistants
| Igor Neyman | ineyman92@hotmail.com |
| Taher Katouzian | tkatouzian@yahoo.com |
| Nika Omid | nomid@ucsd.edu |
| Elliot Azizollahi | eazizoll@ucsd.edu |
| Andrew Phillips | asphilli@ucsd.edu |
| Steve Dizaiy | sdizaiy@ucsd.edu |
| Kristin Bennett | kebennet@ucsd.edu |
| Valeria Pagnon | vpagnon@ucsd.edu |
| Peter Olson | polson@ucsd.edu |
Internet
Special attention will be given to pathway comparison
among different species. This aspect of the course will be based on Internet
databases and specifically the metabolic pathway database (KEGG)
at the Japanese Genomenet WWW Server.
| Bioinformatics
Basics
by H.Rashidi and L.Buehler gives you instructions on using the Internet to retrieve information about metabolic pathways, protein structures, the human genome project, molecular evolution, and hereditary diseases. |
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