Physical Biochemistry 
Summer Session 2001
Syllabus
Web Reader
Group presentations
Requirements and grading
Course outline
Welcome to Physical Biochemistry class for Summer Session II  2001 at the Biology Department at UCSD taught by Dr. Lukas Buehler. This course introduces the principles of physical biochemistry and its applications to the study of macromolecular structure and function. The course covers thermodynamic principles in understanding behavior of macromolecules such as solubility and enzymatic activity. Structure determination techniques are presented to show the experimental approaches addressing structure function relationship of proteins at different levels of resolutions, both conformational and in time. Finally, surface active molecules and biological membranes are discussed including chemical equilibrium phenomena across membranes, self assembly properties of membranes and channel forming peptides and transport processes vital for the function of biological activity in the brain.

Teaching Assistant

 Kristin Bennett

 Updates & Exam Keys

Final exams available outside Bonner Hall 2402.
Class total score average 806 (A>780, B>680) includes up to 400 points for report.
Grade written on Final exam is course grade! Final exam score average 268 points ( = A/B cutoff).
 
 

List of Project assignments
(please note dates of presentations during the last three days of lecture, 9/4 - 9/6)
 

Key to midterm exam

General Information

Grading info on written reports
Group presentations; see guidelines

Study guide for midterm 
Study guide for final exam

Text to fluorescence images
Quick time movie of gap junction structure
Gouy Chapman theory
Textbook
Principles of Physical Biochemistry 

E. van Holde, Curtis, Ho 
Prentice Hall, 1998 		 This text book is specialized on biophysical, physical, and chemical properties of biological systems and macromolecules. It deals in depth with experimental techniques to study physical and chemical properties of proteins and nucleic acids, including their structures. 
 

Many of the specialized topics can also be found in the more general text book
'Biochemistry' by Matthews, van Holde, Ahern, 3rd, Benjamin&Cummings, 2000.

Web Resources

On-line Biophysics textbook
from the Biophysical Society (for reference purposes) 

A link to a practical guide on electrophysiology
Please send questions and comments regarding this web page and course information to Lukas Buehler.

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