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Physiology An essential role for HIF in physiology is the maintenance of whole body oxygen delivery systems through regulation of red blood cell production. Specialized cells in the kidney detect low oxygen tensions in the blood through the HIF pathway and upregulate the transcription of the HIF target erythropoietin, which then signals for increased erythrocytes from the bone marrow. Studies carried out in out laboratory have detailed a novel role for the skin in sensing whole body hypoxia. |
Relevant Publications Johnson RS and Papaioannou VE. (1999) “Methods for the production of genetically manipulated mouse embryos.” in Gene Targeting: A Practical Approach, 2nd Edition, A. Joyner, Editor; IRL Press. Tamura N, Sudo T, Dadak A, Johnson RS, and Karin M. (2000) Requirement for p38a in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102:221-231 Seagroves T, Ryan H, Lu H, Knapp M, Wouters B, Thibault P, Laderoute K, and Johnson RS. (2001) The transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Molecular and Cellular Biology 21: 3436-3444 Scheid A, Wenger R, Schaffer L, Camenisch I, Distler O, Fereno A, Crisitna H, Ryan H, Johnson R, Wagner K, Stauffer U, Bauer C, Gassmann M, and Meuli M. (2002) Huang Y, Hickey RP, Yeh JL, Liu D, Dadak A, Young LH, Johnson RS, and Giordano FJ. (2004) Cardiac myocyte-specific HIF-1a deletion alters vascularization, energy availability, calcium flux and contractility in the normoxic heart. The FASEB Journal 18(10):1138-1140 Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey R, Wagner PD, Kahn CR, Giordano FJ, and Johnson RS. (2004) The loss of skeletal muscle HIF-1a results in altered exercise endurance. PLoS Biology 2:e288 Helton R, Cui J, Scheel J, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Johnson RS, Lipton SA, and Barlow C. (2005) Brain-specific knockout of HIF-1a reduces rather than increases hypoxic-ischemic damage. Journal of Neuroscience 25(16):4099-107 Helton R, Cui J, Scheel J, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Johnson RS, Lipton SA, and Barlow C. (2005) Brain-specific knockout of HIF-1a reduces rather than increases hypoxic-ischemic damage. Journal of Neuroscience 25(16):4099-107 Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, and Haase VH. (2007) Hypoxia-Inducible Factor (HIF)-2 regulates hepatic erythropoietin in vivo. Journal of Clinical Investigation 117:1068-1077 Boutin AT and Johnson RS. (2007) Waiting to inhale: HIF-1 modulates aerobic respiration. (Preview) Cell 129:29-30 Mason S, Ameln H, Duh R, McNulty WJ, Howlett RA, Olfert IM, Sundberg CJ, Poellinger L, and Johnson RS. (2007) HIF-1α in endurance training: suppression of oxidative metabolism. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293:R2059-2069 Boutin A, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt K-U, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, and Johnson RS. (2008) Epidermal sensing of oxygen is essential for systemic hypoxic response.Cell (in press) Mason S and Johnson RS. (2008) The role of HIF-1 in hypoxic response in the skeletal muscle. Chapter 18 in: Advances in Experimental Biology and Medicine: Hypoxia and the Circulation, edited by R. Roach, P. Wagner and P. Hackett, Volume 618, pages 229-244; Springer Verlag, publishers.
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