Alan I. Derman, Ph.D.

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Official web page of the University of California, San Diego
Division of Biological Sciences
Ph.D. Microbiology and Molecular Genetics (1994)
Harvard University
B.A. English (1982)
Yale University
Derman, A. I. and D. A. Agard. 2000. Two energetically disparate folding pathways of alpha-lytic protease share a single transition state. Nature Struct. Biol. 7:394-397.

Murphy, C., Prinz, W., Pohlschröder, M., Derman, A., and J. Beckwith. 1995. Essential features of the pathway for protein translocation across the Escherichia coli cytoplasmic membrane. Cold Spring Harbor Symp. Quant. Biol. 60:277-283.

Derman, A. I. and J. Beckwith. 1995. Escherichia coli alkaline phosphatase localized to the cytoplasm slowly acquires enzymatic activity in cells whose growth has been suspended: a caution for gene fusion studies. J. Bacteriol. 177:3764-3770.

Bardwell, J., Derman, A., Belin, D., Jander, G., Prinz, W. Martin, N., and J. Beckwith. 1994. Pathways of disulfide bond formation in proteins in vivo, p. 270-275. In A. Torriani-Gorini, E. Yagil, and S. Silver (eds.), Phosphate in microorganisms: cellular and molecular biology. American Society for Microbiology, Washington, D.C.

Derman, A. I., W. A. Prinz, D. Belin, and J. Beckwith. 1993. Mutations that allow disulfide bond formation in the cytoplasm of Escherichia coli. Science 262:1744-1747.

Derman, A. I., J. W. Puziss, P. J. Bassford, Jr., and J. Beckwith. 1993. A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J. 12:879-888.

Derman, A. I. and J. Beckwith. 1991. Escherichia coli alkaline phosphatase fails to acquire disulfide bonds when retained in the cytoplasm. J. Bacteriol 173:7719-7772.

Riggs, P. D., A. I. Derman, and J. Beckwith. 1998. A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene. Genetics 118:571-579.

Gotschlich, E. C., M. S. Blake, J. M. Koomey, M. Seiff, and A. Derman. 1986. Cloning of the structural genes of three H8 antigens and of protein III of Neisseria gonorrhoeae. J. Exp. Med. 164:868-881.
Publications
Research Experience
Genentech, Inc. (2000-2003)
Scientist, Cell Culture and Fermentation R&D

Postdoctoral Fellow (1994-2000)
University of California, San Francisco (David Agard)

Graduate research (1986-1994)
Harvard University (Jon Beckwith)
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