Touch sensation and learning:

Suzuki H, Kerr R, Bianchi L, Frøkjær-Jensen C, Slone D, Xue J, Gerstbrein B, Driscoll M, Schafer WR. (2003) "In vivo functional analysis of C. elegans mechanosensory neurons reveals a specific role for MEC-4 channels in the process of gentle touch transduction" Neuron 39: 1005-1017.

Frøkjær-Jensen C, Kindt KS, Kerr RA, Suzuki H, Melnik-Martinez K, Gerstbrein B, Driscoll M, Schafer WR (2006) "Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons" J. Neurobiol. 66: 1125-1139 Epub 2006 Jul 11

Sanyal S, Wintle RF, Kindt K, Nuttley WM, Arvan R, Fitzmaurice P, Bigras E, Merz D, Hebert TE, van der Kooy D, Schafer WR, Culotti JG and Van Tol HHM. (2004) "Dopamine modulates the plasticity of mechanosensory responses in C. elegans" EMBO Journal 23: 473-482.

Kindt KS, Tam T, Whiteman S, Schafer WR. (2002) "Serotonin promotes Go/Gq-mediated neuronal migration in Caenorhabditis elegans" Curr. Biol. 12: 1738-1747.

Calcium imaging and calcium channels:

Bianchi L, Gerstbrein B, Frøkjær-Jensen C, Royal DC, Mukherjee G, Royal MA, Xue J, Schafer WR, Driscoll M. (2004) "The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation" Nature Neurosci 7: 1337-1344+supplementary data

Kerr R, Lev-Ram V, Baird G, Vincent P, Tsien RY, Schafer WR. (2000) “Optical imaging of calcium transients in C. elegans neurons and pharyngeal muscle” Neuron 26: 583-594.

Tam T, Mathews E, Snutch T, Schafer WR (2000) “Voltage-gated calcium channels direct neuronal migration in Caenorhabditis elegans” Dev. Biol. 226: 104-117.

Schafer W, Sanchez BM, Kenyon CJ. (1996) "Genes affecting sensitivity to serotonin in Cenorhabditis elegans." Genetics 143: 1219-1230.

Schafer, WR, Kenyon C. (1995) "A calcium channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans." Nature 375: 73-78.

Nociception and chemosensation:

Hilliard MA, Apicella AJ, Kerr R, Suzuki H, Bazzicalupo P, Schafer WR. (2005) "In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents" EMBO Journal 24: 63-72. Epub 2004 Dec 02.

Kahn-Kirby AH, Dantzker JLM, Apicella AJ, Schafer WR, Browse J, Bargmann CI, Watts JL (2004) "Specific polyunsaturated fatty acids drive TRPV-dependent sensory signaling in vivo" Cell 19: 889-900.

Fukuto HS, Ferkey DM, Apicella AJ, Lans H, Sharmeen T, Chen W, Lefkowitz RJ, Jansen G, Schafer WR, Hart AC. (2004) "G Protein-coupled receptor kinase function is essential for chemosensation in C. elegans" Neuron 42: 581-593.

Tomioka M, Adachi T, Suzuki H, Kunitomo H, Schafer WR, Iino Y (2006) "The insulin/PI3 –kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans" Neuron 51: 613-626.

Egg-laying:

Shyn SI, Kerr R, Schafer WR. (2003) "Serotonin and Go modulate functional states of neurons and muscles involved in C. elegans egg-laying behavior" Curr. Biol. 13: 1910-1915. +supplementary data

Hardaker, LA, Singer E, Kerr R, Zhou GT, Schafer WR. (2001) "Serotonin modulates locomotory behavior and coordinates egg-laying and movement in Caenorhabditis elegans" J. Neurobiol. 49: 303-313.

Waggoner LE , Hardaker LA, Golik S, Schafer WR. (2000) “Effect of a neuropeptide gene on behavioral states in Caenorhabditis elegans egg-laying”. Genetics 134: 1181-1192

Waggoner LE, Zhou GT, Schafer RW, Schafer WR. (1998) “Control of alternative behavioral states by serotonin in Caenorhabditis elegans” Neuron 21: 203-214.

Zhou GT, Schafer WR, Schafer RW. (1998) “A three-state biological point process model and its parameter estimation” IEEE Trans. Signal Process. 46: 2698-2707.

Machine vision:

Huang KM, Cosman P, Schafer WR. (2006) "Machine vision based detection of omega bends and reversals in C. elegans" J Neurosci Methods. Epub 2006 Jul 1

Geng W, Cosman P. Palm M, Schafer W. (2005) C. elegans egg-laying detection and behavior study using image analysis" EURASIP J. App. Sig. Proc. 14 : 2229-2240.

Geng W, Cosman P, Berry CC, Feng Z, Schafer WR. (2004) "Automatic tracking, feature extraction and classification of C. elegans phenotypes" IEEE Trans Biomed. Eng 51: 1811-20.

Feng Z., Cronin CJ, Wittig JH Jr, Sternberg PW, Schafer WR. (2004) "An imaging system for standardized quantitative analysis of C. elegans behavior" BMC Bioinformatics 5: 115.

Geng W, Cosman P, Baek J-H, Berry CC, Schafer WR. (2003) "Quantitative classification and natural clustering of C. elegans behavioral phenotypes" Genetics 165: 1117-1123.

Baek J-H, Cosman P, Feng Z, Silver J, Schafer WR (2002) "Using machine vision system to analyze and classify of C. elegans behavioral phenotypes quantitatively" J. Neurosci Meth. 118: 9-21.

Nicotine:

Gottschalk A, Schafer WR (2006) "Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans" J Neurosci Methods. 154: 68-79 Epub 2006 Feb 6

Gottschalk A, Almedom, RB, Schedletzky T, Anderson AD, Yates JR III, Schafer WR (2005) "Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans." EMBO Journal 24:2566-78. Epub 2005 Jun 30. +supplementary material

McKay, Raizen D, Gottschalk A, Schafer WR, Avery L (2004) "eat-2 and eat-18 are required for nicotinic neurotransmission in the C. elegans pharynx Genetics 166: 161-169.

Kim J, Poole DS, Waggoner LE, Kempf A, Ramirez DS, Treschow PA, Schafer WR (2001) “Genes affecting affecting the activity of nicotinic receptors involved in Caenorhabditis elegans egg-laying behavior” Genetics 157: 1599-1610.

Waggoner LE, Dickinson KA, Poole DS, Tabuse Y, Miwa J, Schafer WR. (2000) “Long-term nicotine adaptation in Caenorhabditis elegans involves PKC-dependent changes in nicotinic receptor abundance” J. Neurosci. 20: 8802-8811.

Selected reviews:

Schafer WR (2006) "Genetics of egg-laying in worms" Ann Rev Genet. 40: 487-509.

Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, Lukas RJ, Markou A, Marks MJ, McCallum SE, Parameswaran N, Perkins KA, Picciotto MR, Quik M, Rose JE, Rothenfluh A, Schafer WR, Stolerman IP, Tyndale RF, Wehner JM, Zirger JM. (2006) "Guidelines on nicotine dose selection for in vivo research". (2006) Psychopharmacology (Berl). Epub 2006 Aug 9

Schafer WR (2005) "Deciphering the neural and molecular mechanisms of C. elegans behavior" Curr. Biol. 15: R723-R729.

Schafer WR (2004) "Addiction research in a simple animal model: the nematode Caenorhabditis elegans" Psychopharmacology Epub 2006 Aug 9..

Schafer, WR (2002) "Genetic analysis of nicotinic signaling in worms and flies" J. Neurobiol. 53: 535-541

Schafer, WR (1999) “How do antidepressants work? prospects for genetic analysis of drug mechanisms” Cell 98: 551-554.

Schafer, WR, Rine J. (1992) "Protein prenylation: genes, enzymes, targets, and functions." In: Annual Review of Genetics 26: 209-37.

Pre-worm work:

Dimster-Denk, DF, Schafer WR, Rine J. (1995) "Control of RAS mRNA by the mevalonate pathway." Mol. Biol. Cell. 6: 59-70.

Schafer, WR, Trueblood CE, Yang C-C, Mayer MP, Rosenberg S, Poulter CD, Kim S-H, Rine J. (1990) "Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the Ras protein." Science 249: 1133-1139.

Finegold, AA, Schafer WR, Rine J, Whiteway M, Tamanoi F. (1990) "Common modifications of trimeric G-proteins and ras proteins: involvement of polyisoprenylation." Science 249: 165-168.

Thorsness M, Schafer W, D'Ari L, Rine J. (1989) "Positive and negative transcriptional control by heme of genes encoding HMG-CoA reductase in Saccharomyces cerevesiae." Mol. Cell. Biol. 9: 5702-5712.

Schafer, WR, Kim R, Sterne R, Thorner J, Kim S-H, Rine J. (1989) "Genetic and pharmacological suppression of oncogenic mutations in RAS genes of yeast and humans." Science 245: 379-385.

Ray, C., M. Igo, W. Schafer, R. Losick, C.P. Moran, Jr. (1988) "Suppression of ctc promoter mutations in Bacillus subtilis." J. Bacteriol. 170: 900-907.

Igo, M., M. Lampe, C. Ray, W. Schafer, C.P. Moran, Jr., R. Losick. (1987) "Genetic studies of a secondary RNA polymerase sigma factor in Bacillus subtilis." J. Bacteriol. 169: 3464-3469.