Selected Publications

Bertrand, J. Y.*, A. D. Kim*, E. P. Violette, D. L. Stachura, J. L. Cisson, and D. Traver. 2007. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development, 134: 4147-4156.

Shaw, G. C., J. J. Cope, L. Li, K. Corson, C. Hersey, G. E. Ackerman, B. Gwynn, A. Lambert, R. A. Wingert, D. Traver, N. S. Trede, B. A. Barut, E. MInet, A. Donovan, A. Brownlie, M. J. Weiss, L. L. Peters, J. Kaplan, L. I. Zon, and B. H. Paw.  2006. Mitoferrin, a mitochondrial transporter disrupted in the zebrafish frascati mutant, is essential for erythroid iron assimilation.  Nature, 440: 96-100.

Panagos, P. G., K. P. Dobrinski, X. Chen, A. W. Grant, D. Traver, J. Djeu, S. Wei, and J. A. Yoder.  2006. Inhibitory and activating immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish.  Immunogenetics, 58:31-40. 

Burns, C. E., D. Traver, E. Mayhall, J. L. Shepard, and L. I. Zon.  2005.  Hematopoietic stem cell fate is established by the Notch-Runx pathway.  Genes and Development, 19:  2331-2342.

Lin, H.-F., D. Traver, C. Abraham, and R. Handin.  2005.  Isolation of the zebrafish CD41 promoter and generation of thrombocyte-specific transgenic lines. Blood, Epub Aug. 11.

Akashi, K., D. Traver, and L. I. Zon.  2005.  The complex cartography of stem cell commitment.  Cell, 121:  160-162.

Fraenkel, P. G., D. Traver, A. Donovan, and L. I. Zon.  2005.  Ferroportin1 is required for normal iron cycling in zebrafish.  J. Clin. Invest., 115:  1532-1541. 

Zhu, H., D. Traver, A. Davidson, T. Dibiase, C. Thisse, B Thisse, S. Nimer, and L. I. Zon.  2005.  Regulation of the LMO2 promoter during hematopoietic and vascular development in zebrafish.  Developmental Biology, 281:  256-269.

Patton, E. E., H. R. Widlund, J. L. Kutok, K. R. Kopani, J. F. Amatruda, R. D. Murphey, S. Berghmans, D. Traver, E. A. Mayhall, J. C. Aster, S. R. Granter, A. T. Look, C. Lee, D. E. Fisher, and L. I. Zon.  2005.  BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.  Currrent Biology, 15:  249-254.

Traver, D.  2004.  Cellular dissection of zebrafish hematopoiesis.  Methods in Cell Biology, 76:  127-149.

Shigematsu, H., B. Reizis, H. Iwasaki, S.-I. Mizuno, D. Hu, D. Traver, P. Leder, and K. Akashi.  2004.  Plasmacytoid dendritic cells originate from both lymphoid and myeloid pathways, both activating human pre-TCRa gene transcription.  Immunity.  21:  43-53.

Ransom, D. G., N. Bahary, K. Niss, D. Traver, C. E. Burns, N. P. Paffett-Lugassy, W. J. Saganic, C. A. Lim, C. Hersey, Y. Zhou, B. A. Barut, P. D. Kingsley, J. Palis, S. H. Orkin, and L. I. Zon.  2004.  Isolation of the zebrafish moonshine gene establishes Transcriptional Intermediary Factor 1g as a critical regulator of hematopoiesis.  PloS Biol.  2:  E237.  Epub Aug 17.

Traver, D., and K. Akashi.  2004.  Common myeloid progenitors.  Handbook of stem cells,  355-376. 

Traver, D., and K. Akashi.  2004.  Lineage commitment and developmental plasticity in early lymphoid progenitor subsets.  Advances in Immunology, 83:  1-54.

Traver, D.*, A. Winzeler*, H. M. Stern, E. Mayhall, J. L. Kutok, D. M. Langenau, A. T. Look, and L. I. Zon.  2004.  Biological effects of lethal irradiation and rescue by hematopoietic cell transplantation in zebrafish.  Blood, 104:  1298-1305.

Langenau, D. M., A. A. Ferrando, D. Traver, J. L. Kutok, J. P. Hezel, J. P. Kanki, L. I. Zon, A. T. Look, and N. S. Trede.  2004.  In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.  PNAS, 101:  7369-7374.

Trede, N. S., D. M. Langenau, D. Traver, A. T. Look, and L. I. Zon.  2004.  The use of zebrafish to understand immunity.  Immunity, 20:  367-379.

Hsu, K., D. Traver, J. L. Kutok, A. Hagen, T. X. Liu, B. H. Paw, J. Rhodes, L. I. Zon, J. P. Kanki, and A. T. Look.  2004.  The PU.1 promoter drives myeloid gene expression in zebrafish.  Blood, 104:  1291-1297.

Traver, D., P. Herbomel, E. E. Patton, R. Murphy, J. A. Yoder, G. W. Litman, A. Catic, C. T. Amemiya, L. I. Zon, and N. S. Trede.  2003.  The zebrafish as a model organism to study development of the immune system.  Advances in Immunology, 81:  253-330.

Traver, D., B. H. Paw, K. D. Poss, W. T. Penberthy, S. Lin, and L. I. Zon.  2003.  Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants.  Nature Immunology, 4:  1238-1246.

Langenau, D. M., D. Traver, A. A. Ferrando, J. Kutok, J. C. Aster, J. P. Kanki, S. Lin, E. Prochownik, N. Trede, L. I. Zon, and A. T. Look.  2003.  Myc-induced T-cell leukemia in transgenic zebrafish.  Science, 299:  887-890.

Jaiswal, S.*, D. Traver*,  T. Miyamoto, K. Akashi, E. Lagasse , and I.L. Weissman.  2003.  Expression of BCR/ABL and BCL-2  in myeloid progenitors leads to myeloid leukemias. PNAS, 100:  10002-10007.

Hock, H., M. J. Hamblen, H. M. Rooke, D. Traver, R. T. Bronson, S. Cameron, and S. H. Orkin.  2003.  Intrinsic requirement for zinc-finger transcription factor Gfi-1 in neutrophil differentiation.  Immunity, 18: 109-120.

Mikkola, H. K. A., Y. Fujiwara, T. M. Schlaeger, D. Traver, and S. H. Orkin.  2002.  Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo.  Blood, 101:  508-516.

BitMansour, A., S. M. Burns, D. Traver, K. Akashi, C. H. Contag, I. L. Weissman, and J. M. Y. Brown.  2002.  Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation.  Blood, 100:  4660-4667.

Traver, D., and L. I. Zon.  2002.  Walking the walk:  migration and other common themes in blood and vascular development.  Cell, 108:  731-734.

NaNakorn, T.*, D. Traver*, K. Akashi, and I. L. Weissman.  2002.  Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S.  J. Clin. Invest., 109:  1579-1585.

Traver, D., T. Miyamoto, J. Christensen, K. Akashi, and I. L. Weissman.  2001.  Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets.  Blood, 98:  627-635.

DiMartino, J.*, L. Selleri*, D. Traver*, M. Firpo, R. Warnke, J. Rhee, S. O'Garman, I. L. Weissman, and M. L. Cleary.  2001.  The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.  Blood, 98:  618-626.

Manz, M. G., D. Traver, T. Miyamoto, I. L. Weissman, and K. Akashi.  2001.  Dendritic cell potentials of early lymphoid and myeloid progenitors.  Blood, 97:  3333-3341.

Traver, D.*, K. Akashi*, M. Manz*, M. Merad, T. Miyamoto, E. G. Engleman, and I. L. Weissman.  2000.  Development of CD8a-Positive dendritic cells from a common myeloid progenitor.  Science, 290:  2152-2154.

Akashi, K.*, D. Traver*, T. Miyamoto, and I.L. Weissman.  2000.  A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.  Nature, 404:  193-197.

Traver, D., K. Akashi, I.L. Weissman, and E. Lagasse.  1998.  Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia.  Immunity, 9: 47-57.

*Equal Contribution