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Anastacia Anishchenko, Ph.D.
University of California, Berkeley
Department of Molecular and Cell Biology
142 Life Sciences Addition # 3200
Berkeley, CA 94720 USA
anastacia [at] berkeley [dot] edu
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I am a Postdoctoral Research Scholar in the
Feller Lab,
which has recently moved from
UC San Diego to
UC Berkeley.
In collaboration with
Chichilnisky Lab at the
Salk Institute, I study correlated
neural activity in the retina and its role in the development of visual circuits
[1]-[4].
We perform electrophysiological recordings using a multi-electrode array (MEA) --
a planar array of 64 to 512 extracellular electrodes. The MEA allows us to record both
spontaneous and light-evoked activity of dozens of retinal cells at the same time.
Being able to monitor so many cells simultaneously opens unique possibilities for
getting insights into the retinal circuitry.
How did I get here? Well, I have been always fascinated by what I think are the two greatest mysteries: the Universe and the Brain.
First, I thought I would focus on the Universe, and so I received a degree in Theoretical Physics from the
Belarusian State University in
Minsk,
Belarus.
However, when I came as a graduate student to
Brown University in Providence, RI, my interest shifted to the Brain.*
For a few years, I had been working under the supervision of
Elie Bienenstock
and building computational models of visual object recognition in cortex [6]. I also visited
SISSA
in Trieste, Italy to study the models of associative memory in small-world networks of neurons with
Alessandro Treves [5].
By the time I was finishing my Ph.D. thesis, I had realized that a purely theoretical approach to unveiling
the mysteries of the Brain is not enough for me. So I received an intensive training in electrophysiology at the
Neural Systems and Behavior
course in Woods Hole, MA, and then joined the laboratory of Marla Feller as a postdoc...
Well, the rest you already know.
- Anishchenko A, Elstrott J, Sher A, Litke AM, Feller MB, Chichilnisky EJ.
A functional mosaic of retinal ganglion cells is established at eye-opening in the mouse, in preparation
- Shah RD, Dhande OS, Chandrasekaran AR, Anishchenko A, Elstrott J, Iwasato T, Swindell E, Jamrich M, Itohara S, Feller MB, Crair MC.
Adenylate Cyclase 1 is required for activity-dependent retinotopic map refinement and response homeostasis, submitted.
- Elstrott J, Anishchenko A, Greschner M, Sher A, Litke AM, Chichilnisky EJ, Feller MB.
Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves. Neuron 2008, 58: 499-506.
- Wang C-T, Blankenship A *, Anishchenko A *, Elstrott J, Fikhman M, Nakanishi S, Feller MB.
GABA-A receptor-mediated signaling alters the structure of spontaneous activity in the developing retina.
Journal of Neuroscience 2007, 27(34):9130-40 (* contributed equally to this work) .
- Anishchenko A, Treves A. Autoassociative memory retrieval and spontaneous
activity bumps in small-world networks of integrate-and-fire neurons. Journal of Physiology Paris 2006, 100(4):225-36.
- Anishchenko A, Hicklin J, Bienenstock E. Committed Complex Cells:
compositional model of visual object recognition in cortex, in preparation.
* "As long as our brain is a mystery, the universe --
the reflection of the structure of the brain -- will also be a mystery." - Santiago Ramon y Cajal