CLUSTAL X (1.82) multiple sequence alignment


Hsa1 ------------------------------------------------------------
Mmu1 ------------------------------------------------------------
Gga1 ------------------------------------------------------------
Xla1 ------------------------------------------------------------
Dre1 ------------------------------------------------------------
Mmu2 ------------------------------------------------------------
Hsa2 ------------------------------------------------------------
Gga2 ---------------------------------------------------MSGLRAPR-
Xtr1 ---------------------------------------------------MNGRKKKRR
Spu1 -------------------------------------------------MASVSVNRKQR
Ame1 -----------------------------------------------------MRSSVIT
Nvi1 ------------------------------------------------------------
Tca1 ----------------------------------------------------------MH
Aae1 ------------------------------------------------------------
Aga1 ------------------------------------------------------------
Dme1 MRKNTIWNYSLIFFCCVLKSISTLDHGPHTVSVDSNRHNTQHQYKQNPNVASQRHSSHES
Cbr1 ------------------------------------------------------------
Cel1 ------------------------------------------------------------


Hsa1 --------------MDVCVRLALWLLWGLLLHQGQSL----SHSHSEKATGTSSGANSEE
Mmu1 --------------MDVCARLALWLLWGLLLHQGQSL----SHSHSEKNTGASSGATSEE
Gga1 ------------------------------------------------------------
Xla1 ---------------MLWCRTLLWALCASFLQPSRPE----SPTES----------TEED
Dre1 --------------MEFSGLVTFWIACICFLLQCRAD----KLNPVN------TDPLPAD
Mmu2 ---------MLLFGLLVAGVADG-CDLVPRHLRGRRA----SGSAGAAASPSAAAAGERQ
Hsa2 ---------MLVLGLLVAGAADG-CELVPRHLRGRRA----TGSAATAASSPAAAAGDSP
Gga2 -GVPAAPGCLLLLGLLLVGAAAAECELEAADVPGGRR----GARGSTAASSSSSSAADSA
Xtr1 LTPPLLPQWVCACGAVERRYPGVCLALLLAVLLLLPP----VSVCTLCEAGGPRRRRDTP
Spu1 LSNRAYRDIYAIPVFIMFVWTTCVCLCVVGQFPVDSTRLTPASGTAKKGGGGTSAPLTDR
Ame1 NVIVLFGLHFLYWCCNTVDASGGALDASSNFQSGSTGSSHSKVTAFSATLTDGLAQAVAH
Nvi1 ------------------------------------------------------------
Tca1 TRGLIFWLILSFYRSAAEDAATEKLKSRDNFKSTYSAN-----------------DLLLS
Aae1 ----------------------------------------------------TYGS----
Aga1 -----------------------------------RNSYTVLSQAMSQAVHHEFGIGAMA
Dme1 GQSLHNSQSEHVTHIAASHAGSGGEHSTHLAQNLHRSSYNLLSEAMSQAVSNEFSSMG-S
Cbr1 ----------------MGNHRTLWNAFAFFCL-------------------------IHI
Cel1 ----------------MG--RVSWIIALYLTIN------------------------VVI


Hsa1 STAAEFCRIDKPLCHSED---EKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYH
Mmu1 STEAEFCRIDKPLCHSED---EKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYH
Gga1 -----------------------------------MDDDANGNVDVEESDEFLREDLNYH
Xla1 PMLSEFCRIDKLLCHSTD---ELLSFEAVMSIHKQMDDDANGSVDVEESDEFLREDLNYH
Dre1 NGVSELCRIDEPLCQDEN---AILSFEAIRSIHKQMDDDDNGNVDVLETDGFLREDLNYH
Mmu2 ALLTDPCMSLSPPCFTEE---DRFSLEALQTIHKQMDDDKDGGIEVDESDEFIREDMKYK
Hsa2 ALMTDPCMSLSPPCFTEE---DRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYK
Gga2 AVVTDPCSSLSPPCFTEE---DRFSLEALRMIHKQMDDDKDGGIEVDESDEFLREDMQYK
Xtr1 ALLSDPFNSLSPPVLTED---DRSSLEAICTIHKQMDDDKDGGIEVEESDEFLREDLNYK
Spu1 SFEYPECSTKDVACIDDHREKDRLGKEGIMLLHRQMDDDHDGDVEPSESDEFLRDELKYE
Ame1 EAGSDTCNDDLACLTTMA-SHDRLGLEAIKSLHSQLDDDANGNVDLSESDDFLREELQYE
Nvi1 ----------------MA-SNDRLGLEAIKSLHSQLDDDANGNIDLSESDDFLREELQYE
Tca1 DSSINTCSIDDFACLTMA-ANDRLGLEAIKTLHQKLDDDANGNVDLSESDDFLREELQYD
Aae1 GSADGACSADDLDCIAH---HDHLGMEAIRSLHQQLDDDDNGDIDLSESDDFLREELKYD
Aga1 GDAGSACTIDDIDCLAH---HDQLGMEAIRSLHQQLDDDDNGDIDLSESDDFLREELKYD
Dme1 GSADGACAADDFDCYSGS-VQDRFGMEAIASLHRQLDDDDNGNIDLSESDDFLREELKYD
Cbr1 VGGAERVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMR
Cel1 VVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMR
:*** .*.:: *: *::::::

Hsa1 DPTVK--HSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKL
Mmu1 DPTVK--HSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVIQWLITYVELPQYEETFRKL
Gga1 DPTVK--HSTFHGEDKLISVEELWKAWKTSEVYNWTVDEVVQWLITYVELPQYEETFRKL
Xla1 DPTAK--HSTFHGEDKLISVEDLWNSWKISEVYNWTVDEVAQWLITYVELPQYEETFRKL
Dre1 DPKGK--HNTFHGDDQFISVEDLWNAWKSSEVYNWTVDEVVKWLIDYVELTQYVEAIKKL
Mmu2 DATNK--HSHLHREDKHITVEDLWKQWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDN
Hsa2 DATNK--HSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDN
Gga2 DASNK--HSHLHREDKHITIEDLWRRWKTSEVHNWTQEDTLQWLSEFVELPQYEKNFRES
Xtr1 DASQK--HNHLHREDKHITVEDLWAQWKTSEVHNWTEEETLQWLLEFVELPQYEKNFREN
Spu1 DDFER--HSQLHRNDKEISAEELWKGWKYSEVYNWTVDKTVKWLEDSVDLPQYAERFQNN
Ame1 AGYERRQRAFHHNDDMHISVRELWEAWLRSEVHNWTIEQTSEWLSSNVDLPQYVPTFIQH
Nvi1 AGYERRQRAFHHNDDMHISVRELWDAWLRSEVHNWTIEQTSEWLSTNVELPQYVPTFIQH
Tca1 SGYERRQKAFHRNDDMHISVKELWEAWLKSEVHNWTVEQTTDWLVSSVDLPQYVPSFISH
Aae1 SGYEKRHRAFHFNDDMHISVKELWEAWLRSEVHNWTVDQTTEWLAQSVQLPQYVRLFRLH
Aga1 SGYEKRHKAFHFNDDMHISVKELWEAWLRSEVHNWTVDQTTEWLAQSVQLPQYVPLFRLH
Dme1 SGYEKRQKAFHFNDDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVDLFKLH
Cbr1 GSERTRRENKFHGDDEAITVDDLWEAWFESIERTWTNERLVEWLINDVNIPSIIETVKLK
Cel1 GSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAK
. :* *: :** * * .** : .** *::.. .

Hsa1 QLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLV
Mmu1 QLTGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLV
Gga1 QLSGHAMPRLAVNNATMMGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLV
Xla1 QLSGRDMPRLAIANATMTGTLLKMTDRSQRQKLQLKALDTVLFGPPLLTRHNHLKDFMLV
Dre1 NFSGTAMPRLAVKNNTLTQTVLKILDRSHVQKLQLKALDTVLFGAPMMNRHNHLKDFMLV
Mmu2 NVKGTTLPRIAVHETSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILT
Hsa2 NVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILT
Gga2 NVNGTTLPRIAVNEHAFMISHLKIIDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFVLT
Xtr1 SVKGTALPRIAVNEPVLMISQLKITDRSHRQKFQLKALDVVLFGPPTRPPHNWVKDFILT
Spu1 GIEGSALPRLATNNGHFMTAILGITDPIHRQKISLKAMDVVLFGPP-KPMHNYLKDWLLV
Ame1 RVTGATLPRLAVNNMHYLTNVLGIKDPIHKQKIALKAMDVVLFGPPKDTGH-SVKDLILI
Nvi1 RVTGATLPRLAVNNMHYLGNVLGIKDPIHKQKIALKAMDVVLFGPPKDTGH-SLKDLILI
Tca1 KVTGANLPRLAANNVNYLN-HLGIKDPIHKQKIVLKAMDVVLFGPPKDGQP-HWKDLTLI
Aae1 KVTGKVLPRLAVNNMHYVSNVLGIKDPIHKQKIALKAMDAVLFGPPRETGT-RWKDLLLV
Aga1 KVTGKVLPRLAVNNMHYVSNVLGIKDPIHKQKIALKAMDAVLFGPPRETGT-RWKDLLLV
Dme1 KVTGAALPRLAVNNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGT-RWKDYILV
Cbr1 KIDGKILPRFASPTSDYLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNK--TKDILLA
Cel1 KIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNR--TKDILLA
. * :**:* * : . **: *:::*.**** ** *

Hsa1 VSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEV
Mmu1 VSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEV
Gga1 VSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLQKAQEEHRSVEV
Xla1 VSIVIGVGGCWFAYIQNRYSEDHMKKMMKDLEGLHRAEQSLHDLQERLQKAQEEHHTVEV
Dre1 VSIVIGMGGCWFAYIQNRHSKDHMKKMMKDLDSLQRAEQSLHDLQQKLQIAQEEHRSVEV
Mmu2 ISIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRTVAV
Hsa2 VSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV
Gga2 VSIVIGFGGCWFAYTQNRTSKEHITKMMKDLESLQTAEQSLLDLQERLEKAQEENRNVAV
Xtr1 ISIVIGVGGCWFAYTQNRTSKEHISQMMKDLEGLQKAEISLLELQDRLEKAQEENRTVAV
Spu1 ISLVVALGGCWFAFIQHRFSQSHVKQLLREMESLSSAEDSLKELQEKLNVAQEDHKSAVR
Ame1 TLLFGALIGCWYAYQQKKNSQKHLHRMMKDMESLHKAELALEDLQKELERARMEQESVTT
Nvi1 TLLFGALIGCWYAYQQKKSSQKDLHRMMKDMESLHKAELELKSLQKEFEIVKMEQESATT
Tca1 VLLIGGGIGVWYAFQQNKKFKNHLNRMNRDMDSLQNAEKALENLQKELEEAKQAQEDVIT
Aae1 TLLLTAIIGSWYAYQQNKNAKIHLKRMAKDVEGLLKAEVALKDMQKELERARLEQENVDK
Aga1 TLLLTAIIGSWYAYHQNKSAKIHIRRMAKDVEGLLKAEVALKEMQKELEQARIEQENVGK
Dme1 TLLLSAIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVAT
Cbr1 FLALLLTSLIFLYVRQKQKAQHKLNELSNKLTELKSMETEFEDVQKMLSDERS-------
Cel1 FLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERS-------
. : *:: : .: .: ..: * * : .:*. : :

Hsa1 EKVHLEKKLRDEINLAKQEAQRLKELREGTENE-----RSRQKYAEEELEQVREALRKAE
Mmu1 EKVHLEKKLRDEINLAKQEAQRLKELREGTENE-----RSRQKYAEEELEQVREALRKSE
Gga1 EKVHLEKKLQDEISIAKQEAHRLRELREGTENE-----LSRQKYAEQELEQVRMALKNAE
Xla1 EKVHLEKKLQNEISLAKQEAQRLRELREGTENE-----LSRQKYAEQELEQVRMALKNAE
Dre1 EKVNLEQKLRDEINTAKQEAQRLKELREGTENE-----LSRQKYAEEELEQVRMALKKAE
Mmu2 EKQNLERKMMDEINYAKEEACRLRELREGAECE-----LSRRQYAEQELEQVRMALKKAE
Hsa2 EKQNLERKMMDEINYAKEEACRLRELREGAECE-----LSRRQYAEQELEQVRMALKKAE
Gga2 EKQNLERKMMDEINDAKREAHRLRELREGAECE-----LSRLKYAEEELVQVRMALKKAE
Xtr1 EKQNLERKMMDEISDAKREAHRLRELREGAECE-----LSRLKYAEEELVQVRMALKKAE
Spu1 EKQSIEKQLTDEIETAKHEARRLERERIGDDTDGNSDLATQLSLAEEELVQVRSALDEAE
Ame1 EKQNLEKRLQDESVGLHAS-YSDLEVSQ----------------LKAEIEMLKVELQRAE
Nvi1 EKQNLEKRLKDESMGLNTS-SSDLEVSQ----------------LKAEIEMLKMELQRAE
Tca1 EKQNLEKKLQDSKTDLDSLPYSDLEVNQ----------------LKAEIEMLRTELQIAE
Aae1 EKMDLERRLREAPS-TSSS-NSDLMVQE----------------LKQEIEMLRSELSRAE
Aga1 EKMDLERRLREAPT-LSSS-SSDLELQQ----------------LKQEIEVLRSELNRAE
Dme1 EKLDLERRLKEAPT-LSSS-NSDLEVQQ----------------LKKEIEMLRNELSRAE
Cbr1 -----KRSISDGIVS------------------------------KTEMENLRVQLEEAE
Cel1 -----KRSISDGVVN------------------------------HTEMENLRVQLEEAE
:: : : . *: :: * :*

Hsa1 KELESHS-SWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLF
Mmu1 KELESHS-SWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLF
Gga1 KELESHC-SWAAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLF
Xla1 KELESHS-NWSAPDALQKWLQLTHEVEVQYYNIKKQNAEKQLMLAKEGAEKIKKKRNTLF
Dre1 KELESRS-SWSPPEALQKWLQLTHEVEVQYYNIKKQNAERQLQVAKEGAEKIKKKRNTLF
Mmu2 KEFELRS-SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVF
Hsa2 KEFELRS-SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVF
Gga2 KEFELRS-NWSVPEALQKWLQLTHEVEVQYYNIKRQHAEMQLAIAKDEAEKIKKKRSTVF
Xtr1 KEFELRS-NWSVPETLQKWLQLTHEVEVQYYNIKKQNAEMHLAIAKDEAE----------
Spu1 RRLSEEI-NWSAPMTLQQWLQLTYEIEYRYYVSKRVAAAKQLQVAKEECEKLRRKRASLI
Ame1 GELEDR--CWSPPPGLQHWLQLTHEIENKAYTKKKISAEKQLQQAREACEKLRKKRSSLV
Nvi1 GELEDR--CYSPPVGLQHWLQLTHEIENKSYMKKKQSAEKQLQSAREACEKLRKKRSSLV
Tca1 GELKDR--CWSPPPGLQQWLQLTHEIENKAYMKKKASAEKQLQQAREACEKLRKKRSSLV
Aae1 VEINDH--CWTPPQGLQNWLQLTFELENKQHIRKRVMAEKQLMQAREACEKLKKKRSSLV
Aga1 VEIHDH--CWTPPQGLQSWLQLTYELENKHHIRKRIMAEKQLEQAREACEKLRKKRSSLV
Dme1 FELVDN--CWSPPPQLQSWLQYTYELESKNHQKKRTSAEKQLQSAREACEKLRKKRSSLV
Cbr1 RRLEANTNGSGTPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVL
Cel1 RRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAIEMVDRLQKKQGSVL
.: . * ** *: * * * :: . .: * : :

Hsa1 GTFHVAHSSS--LDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHS
Mmu1 GTFHVAHSSS--LDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHS
Gga1 GTFHVAHSSS--LDDVDHKILTAKQALSEVTAALRERLHRWQQIELLCGFQIVNNPGIHT
Xla1 GTFHVAHSSS--LDDVDHKILTAKQALSEVTAALRERLHRWQQIETLCGFQIVNNPGLHA
Dre1 GTFHVAHSSS--LDDVDHKILAAKQALGEVTAALRERLHRWQQIELLTGFTLVHNPGLPS
Mmu2 GTLHVAHSSS--LDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPS
Hsa2 GTLHVAHSSS--LDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPS
Gga2 GTLHVAHSSS--LDEVDHKILEAKKALSELTTCLRERLYRWQQIEKICGFQIAHNSGLPS
Xtr1 ------------------------------------------------------------
Spu1 GSFRIAHGTS--LDAVDQRIVSARTALHEVTAELKERTHRWNQIESVCQFAIMNNPGFQI
Ame1 GAFVSTHGKS--IDEVDKSIVEARTALNEVTAELQERVHRWKQIELLCGFNIINNNGLSY
Nvi1 GAFVSTHGKS--IDEVDKSIVEARTALNEVTAELQERVHRWKAIELLCGFNIINNNGLSY
Tca1 GAFVSTHGKS--IDEVDRSIVEARTALNEVTQELQERVHRWKQIEMLCGFSIINNNGLQF
Aae1 GAFVSTHGKS--IDDVDRSIVEARNALNDVTNDLQERMHRWKNIENLLGFSIVNNNGLAY
Aga1 GAFVSTHGKS--IDDVDRSIVEARNALNDVTNDLQERMHRWKQIETMLGFGIVNNSGIAH
Dme1 GAFVSTHGKS--IDDVDRSIVEARNALGDVTNELQERLHRWKQIETCLGLNIVNNNGLPY
Cbr1 SSLKLATGAASTSDQVDSKIFALKNRMEKIHTLTRETQERWMQIESLCGFPLLYLNETEH
Cel1 SSLKLATGAASTSDQVDSKIFALKSRMEKIHTLTRETQERWLQIESLCGFPLLYLNETEH


Hsa1 LVAALNIDPSWMGSTRP-----NPAHFIMTDDVDDMDEEIVS------------PLSMQS
Mmu1 LVAALNIDPSWMGSTRP-----NPAHFIMTDDVDDMDEEIVS------------PLSMQS
Gga1 LASALNIDPGWMGTPRP-----NPSHFIMTDDVDDLDEEIVS------------PMSMQS
Xla1 LMTALNIDPSLMGVSRP-----APTHFIMSDDLDDLDEDIVS------------PITMQS
Dre1 LASALNLDPSFMGG-RG-----TPQHF-MSDDMDDMDEDIVP------------PGTLQS
Mmu2 LTSSLYSDHSWVVMPRV-----SIPPYPIAGGVDDLDEDTPPIVPQFPGTVAKPAGSLAR
Hsa2 LTSSLYSDHSWVVMPRV-----SIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLAR
Gga2 LTSSLYSDHSWVVMPRV-----SIPPYPIAGGVDDLDEDTPPIVSQFHGSIVKPPSTLAR
Xtr1 ------------------------------------------------------------
Spu1 LMASMG----------------GIPNGADLPGMVNLNK----------------PSPLPL
Ame1 LETVLY-RGTPNGRGLG-------LRGRLS-SQDDLDDEASSVYSPSSCGAAG-------
Nvi1 LENILY-RGAPNGRSLG-------FRGRLS-SQDDLDDDVSSLYTPSVSGAAGRLSVKSC
Tca1 LENTLY-RNT-NGRALP-------VRGRIS-SQDDLDDDTASLY-----GHQG-------
Aae1 LENLLYNRNSVGGKSYRCEYYFLSLSTREVVSQDDLDDDS--------------------
Aga1 LENLLYNRNGVAGKTYRCKHPTAAVMSRLSSSQDDLDDDS--------------------
Dme1 LENVLYGRNG-GLQSSMGMSSTKGSRARITNSTEDLDDES--------------------
Cbr1 LNRAVNANSHFYNNSQEG----SSSSGSITNSANQQNLAKKP------------------
Cel1 INRSI-ASSHFYNKSHEG----SSSSGSISNAHSNPNAVN--------------------


Hsa1 PSLQSSVRQRLTEP--------------------------------------QHGLGSQR
Mmu1 PSLQSSVRQRLTEP--------------------------------------QLGLGSQR
Gga1 PALPSTVRQRLVDP--------------------------------------QHGHGSQR
Xla1 PNLS--LRQRHVDS--------------------------------------QLALGPQR
Dre1 PSMMS-LRQRHIDP--------------------------------------QMALGSQR
Mmu2 SSSLCRSRRSIVPSSPQSQRAQLPAHAPLAAHPRHPHHPQHPQHSLPSPDPDILSVSSCP
Hsa2 SSSLCRSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCP
Gga2 SSSLCRSRRNVVPSSPQSQ------------------------HALHSPDPDILSVSSCP
Xtr1 ------------------------------------------------------------
Spu1 P-----------------------------------------------------------
Ame1 -----------------------------------------------TADNLTWKESSVP
Nvi1 NLCLNLRRRMTAIGTEEDV-------------------------YIGLPESLGWKESSIP
Tca1 ------------------------------------------------------KSISFD
Aae1 ---------------------------------------------------VQGKQLSFD
Aga1 ---------------------------------------------------VQGKPISFD
Dme1 ---------------------------------------------------IQGK-LNFE
Cbr1 --------------------------------------------------PSSITTTTST
Cel1 ---------------------------------------------------SNFVKKVSP


Hsa1 DLTHSDSESSL-HMSDRQR---------VAPKPPQMSR---AADEALN-AMTSNGRHRLI
Mmu1 DLTHSDSESSL-HMSDRQR---------VAPKPPQMGR---AADEALN-AMPSNGSHRLI
Gga1 DLTRCDSESSIPHLSEAQRLPSAA-PKLLAARPALLTR---SIEDAVP-GHTPNGGSRHA
Xla1 DLSRSDSESSIPYMIEQRVSG----HSSKIPSSKALPR---TLEEVPSGSQTPNGGNRHL
Dre1 DLNRSDSDSSLCISQTGEQLRLSYSSKGFPVKPTSLLHGPHSRSEEGAQSHTHNGGNRVH
Mmu2 ALYRNEEEEEAIYFTAEKQWEVPDTASECDSLNSSSGR---KPSPPSSLEMYQTLSSRKI
Hsa2 ALYRNEEEEEAIYFSAEKQWEVPDTASECDSLNSSIGR---KQSPPLSLEIYQTLSPRKI
Gga2 ALYRTEEEEEAIYFSADKQWEVQETGSECDSLNSSIGR---KQSPPSSLEMYQTLSPQKV
Xtr1 ------------------------------------------------------------
Spu1 ------------------------------------------------------------
Ame1 PDSSSSETG-KETPPESNVVHFTVGDAPDEPIRSSNKEKSGIVRSYSQDTNMLLPVEDKT
Nvi1 PDSSSSETGGKDTPPEA--VHFTLGDGLEESSPTSP------VAVPALAPTAAAPTTTTT
Tca1 DDSHDSD-----------------------------------------------------
Aae1 NFSVFSSE----------------------------------------------------
Aga1 NFSMFSSE----------------------------------------------------
Dme1 NFSLLATE----------------------------------------------------
Cbr1 SAPQATTSATIQFVPTG-------------------------------------------
Cel1 PIPPSQQTANLRFVPTE-------------------------------------------


Hsa1 EGVHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSPSAPPGGSPHLDSSRSHSPS
Mmu1 EGVHPGSLVEKLPDSPALAKKTFMALNHGLDKAHSLMELNPSVPPGGSPLLDSSHSLSPS
Gga1 EPPGP----ERPSESPSVMKK-MMMVNHGMEKSSSLGEIGHPAASKHS-HSDSSRSHSPS
Xla1 ELANVGAGHESVPESP-------QMSNKLSEKSPSLGEISTAG--TIQSHSDSSRSHSPS
Dre1 DGGPS---PDGVPDSP-----ILMKKLYGIEKSASMSEIHGSQ--AAMSMSESSRSLSPN
Mmu2 SRDELSLEDSSRGESP-VTADVSRGSPECVGLTETKSMIFSPASRVYNGILEKSCSMHQL
Hsa2 SRDEVSLEDSSRGDSP-VTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQL
Gga2 SREELSLEESSTGDSSSLTADISRGSPDCVGMAETKSMIFSPASKVYNGILEKSCSMNQL
Xtr1 ------------------------------------------------------------
Spu1 ------------------------------------------------------------
Ame1 TSSFLSKTSYSENSLDSSNQDRGGQQRIGPNPCTVPASSVTSINSASGQSCSNNRKGASR
Nvi1 PMPLVPRQDRLLAAFDKIPEDK----VLGS---SSSSTMVRSVSQDTNLILADER-AVPA
Tca1 ------------------------------------------------------------
Aae1 ------------------------------------------------------------
Aga1 ------------------------------------------------------------
Dme1 ------------------------------------------------------------
Cbr1 --------------------------------KTDGSIHSEDVSPVVEDQITIPRSLTQD
Cel1 --------------------------------QSD-SIHSEDTSPIVED-VAISRSLTQD


Hsa1 SPDPDTPSPVGDSRALQASRNTRIPHLA--GKKAVAEEDNGSIGEETDSSPGRKKFPLKI
Mmu1 SPDPDTPSPVGDNRALQGSRNTRIPHLA--GKKAMAEEDNGSIGEETDSSPGRKKFPLKI
Gga1 STDPDTPSPISDCRPN-SSKSTRIPQLA--AKKSAGDEDGSLTGDEVDPGQSKKKFPLKI
Xla1 STEADTPSPGTESKHN-NSKGTRIPQLA--GKKAVAEDDSGSTGEDTDSVSGKKKLTLKI
Dre1 STEPDTPSPTG---LTGGKAGNRIPQIS--SKKSPLEEDSGSTGEDTDSAASRKKHTFKI
Mmu2 SSGIPVPHPRHTSCSSAGNDSKPVQEASNVSRVSSIPHDLCHNGEKSKKPSKIK----SL
Hsa2 SSGIPVPKPRHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIK----SL
Gga2 SSGIPVVKPRHTSCSSASSDSKPSQEVCSVPRISSIPQDLYQNGEKNKKPSKIK----SL
Xtr1 ------------------------------------------------------------
Spu1 ------------------------------------------------------------
Ame1 EGQATSAGDDAETLSTDSSSTMDNDDPKKRSRKILFAFKRNKPKEVSSLIFLAGNVYIYT
Nvi1 TTTASNTTSSFLTKTSYSENSLEQAASGSVEKLGRLSTLKKSLRDLPTVMSLDEETLSTD
Tca1 ------------------------------------------------------------
Aae1 ------------------------------------------------------------
Aga1 ------------------------------------------------------------
Dme1 ------------------------------------------------------------
Cbr1 LSE-DMQSIVSGSTNGTS--SGIKKRKGILPKLFRRNTSKSSSLGGTSN-----------
Cel1 LAEADMQSIVSGSTNGSGSVAALKKRKGIFPKLFRRNTSKSSSLGGTSN-----------


Hsa1 FKKPLKK-----------------------
Mmu1 FKKPLKK-----------------------
Gga1 FKEPRK------------------------
Xla1 FKKPKK------------------------
Dre1 FKKQKK------------------------
Mmu2 FKKKSK------------------------
Hsa2 FKKKSK------------------------
Gga2 FKKKCK------------------------
Xtr1 ------------------------------
Spu1 ------------------------------
Ame1 P--TEDIDILFEYSSRLS-DANSSSFETIS
Nvi1 SNSTADNDDMKRRRRKLHFPAFRKSKNKPS
Tca1 ------------------------------
Aae1 ------------------------------
Aga1 ------------------------------
Dme1 ------------------------------
Cbr1 ------------------------------
Cel1 ------------------------------