Figure S2B. Subdomain D4 multiple alignment


Eco15 KEMSGHVTANNHTFS-TAKFPSEGFAGAYYTLNNDNFEAGKTVDDYMFSSSQ-GWVSVDA
Eco25 KIMSGTVLVNGANLP-TTTFPSQGFTGAYYQLNNDNFAPGKTAADYEFSSSA-SWVDVDA
Yfr2 -PVFTGIIAGGYDFALNDGFPKTGFNQATFTIN-----MNG-TADYSWSSNQPAAVTVNS
Yps4 -MKNLDVTVGDTTFDGDAGFPTTGFVGAAFKVN-----SGGDNSLYDWSSSAPALVSVSG
Ype5 -ATLNTPANTYSGFNINSGFPTTGFKNTHFQLSPHG--ITGANSDYDWVSSH-PNVSVSN
Yps2 -PTLTGILVNGQNFATDKGFPKTIFKNATFQLQMDN--DVANNTQYEWSSSFTPNVSVND
Eco6 -VEVELLSVNGVKFRATDGFPETGFDGAKFTLLLT---HNMKNTDYNWTAGI-YGINVDS
: ** * : : : * : :. : *.

Eco15 SGKVSFANI--GDQTSVTISAVPRQ-GGTTYQTLIKLK
Eco25 TGKVTFKNV--GSKWER-ITATPKT-GGPSYIYEIRVK
Yfr2 SGQVTFNGP-PSGT--VTITATPNN-GGSPQSYSFTVE
Yps4 EGVVTFNAVFPTGTPAITISATPKG-GGSPLSYSFRV-
Ype5 TGAITLQDN-PGGK--VTITATWKHDSSKVFTYDFTL-
Yps2 QGQVTITYQ-TYSE--VAVTAKSKKFPSYSVSYRFYP-
Eco6 NGEVTLSVL---IRSEVTITGKPKNGKGNDVVFKFKI-
* ::: ::. . . :