CLUSTAL X (1.81) multiple sequence alignment HtrA_Cmu ----MMKRLLCVLLSTSVFSSPMLGYSAPKKDSSTGICLAASQSDRELSQEDLLKEVSRG Orf_Ctr ----MMKRLLCVLLSTSVFSSPMLGYSASKKDSKADICLAVSSGDQEVSQEDLLKEVSRG HtrA_Cpn MITKQLRSWLAVLVGSXLLALPLSGQAVGKKESRVS----------ELPQDVLLKEISGG ExeC_Ahy ------------------------------------------------------------ ExeC_Asa ------------------------------------------------------------ Orf_Vch ------------------------------------------------------------ OutC1_Pch ------------------------------------------------------------ OutC2_Pch ------------------------------------------------------------ OutC_Pca ------------------------------------------------------------ Orf_Kpn ------------------------------------------------------------ EtpC_Eco ------------------------------------------------------------ XcpP_Pae ------------------------------------------------------------ Orf_Pal ------------------------------------------------------------ GspC_Bce ------------------------------------------------------------ GspC_Bps ------------------------------------------------------------ Orf_Ccr ------------------------------------------------------------ Orf_Eco ------------------------------------------------------------ Orf_Aae ------------------------------------------------------------ XcpP_Ppu ------------------------------------------------------------ HtrA_Cmu FSKVAAQATPGVVYIENFPKTGSQAIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQ Orf_Ctr FSRVAAKATPGVVYIENFPKTGNQAIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQ HtrA_Cpn FSKVATKATPAVVYIESFPKSQAVTHPSPG-RRGPYENPFDYFNDEFFNRFFGLPSQRE- ExeC_Ahy ------------------MTLPFRNDLLSSLLARCKTVPLSRFSQPLF-WLLLLLLAHQC ExeC_Asa ------------------MTLPFRDDLLSSLLARCKTVPLSRFSQPLF-WLLLLLLAHQC Orf_Vch --------------------MEFKQLPPLAAWPRLLSQNTLRWQKPISEGLTLLLLVASA OutC1_Pch ------------------------------MNISKLPPLSPSVIRRILFYLLMLLFCQQL OutC2_Pch ------------------------------MNISKLPPLSPSVIRRILFYLLMLLFCQQL OutC_Pca -------------------MARLQAFKDPSFHSLVATFRSLPLIRRFVLGLILLLICQQL Orf_Kpn -------------------MSKGIKMHNSVMRLTIPNKKIINYAPHIVTSIILFFICQQL EtpC_Eco --------------------MLFFLSFRGDRGLFIKDIVLKMLTPNRLLCVILLIAGYQL XcpP_Pae --------------------MIPRRSSDITIKTRSDVLPFSGASSRWLQRYAPALLAVAL Orf_Pal ------------------------------MSSTRTRLP------AWLQRHGVTGLCLLV GspC_Bce ---------------------------------------------------MNALSIRIL GspC_Bps ---------------------------------------------------MNALSIRIL Orf_Ccr ------------------------------------------------------------ Orf_Eco -----------------------------------------------MFWLMLLIISAKM Orf_Aae ---------------------------------------------------MYLVYALSL XcpP_Ppu -----------------------------------------------------MSFASRL HtrA_Cmu PRPQQRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQKYTAKIIGLDPKTDLAV Orf_Ctr QRPQQRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQKYTAKIVGLDPKTDLAV HtrA_Cpn -KPQSKEAVRGTGFLVSPDGYIVTNNHVVEDTGKIHVTLHDGQKYPATVIGLDPKTDLAV ExeC_Ahy AGLTWRLLDLGS----QQASQP-WQPAMVASQGQGSARLDLSGISRLSLFG---KAKQQA ExeC_Asa AGLTWRLLDLGS----QQSSQP-WQPAVAGSQGQGKARLDLGGVSRLALFG---KAKQQA Orf_Vch WTLGKMVWVVSA----EQTPVPTWSPTLSGLKAERQP-LDISVLQKGELFGVFTEPKEAP OutC1_Pch AMIFWRIGLP-------DNAPVSSVQITPAQARQQPVTLN-----DFTLFGVSPEKNKAG OutC2_Pch AMIFWRVGLP-------DNSPVASVQITPAQARQQPVTLN-----DFTLFGVSPEKNRSG OutC_Pca AVLTWRFLLP-------EDSRIVGVSVTPAQAKEKPATPG-----DFTLFGHAPDADAST Orf_Kpn AQLTWKIILPVN----FTDNALSSADMTSPAAPSAETALP-----RFTLFGLAEKTSASA EtpC_Eco VSVIHHFWLTQA----ASVPGLSRVSAPETAVTGDQTEERF----VFTLFGRASPLSSEG XcpP_Pae IIAMSISLAWQA---AGWLRLQRSPVAVAASPVS-HESIRSDPTRLARLFGTSAQDP--- Orf_Pal VLLITLSLSKQS---IDFLRLLRSEAAPPPAPESIAERQPLSIQRLQHLFGTPAARPRG- GspC_Bce SLALFAGLCATA---TYWVVTLSAREAPLPAAAA---RLPIRTEDAAALFGGQLDKN--- GspC_Bps SLALFAVLCATA---TYWVVTLSAHQAPLPAAAA---RTPVRTEDAAALFGGQLTRS--- Orf_Ccr -----------------MWVFAAPVGAVSSPAKAPRPPVDLSVLARFDAFGATGGSAGG- Orf_Eco AHSLWRYISFSA----EYTAVSQPVNKPSRVDAKTFDKNDVQLISQQNWFGKYQPVAAQV Orf_Aae AFTLSVFLSVFS--LYYLFNRSLDINFVPKVKKEESVNLANLQGKLKEIFNYSVQEVKTS XcpP_Ppu ITGGCLTLAGWL----AAQCVLQLGRQPQPASRSPATETQLPGLMVGHWQAHVDDGA--- HtrA_Cmu IKIQAKNLPFLTFGNSDQLQIGDWSIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFI Orf_Ctr IKIQAEKLPFLTFGNSDQLQIGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFI HtrA_Cpn IKIKSQNLPYLSFGNSDHLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFI ExeC_Ahy QAADAV---------AADAPKTQLNAQLNGVLASSDPAKSIAIIAHNGVQNSYGIGDFID ExeC_Asa RAADAV---------AADAPKTQLNAQLNGVLASSDPAKSIAIIAHSGVQNSYGIGDFID Orf_Vch VVEQPV---------VVDAPKTRLSLVLSGVVASNDAQKSLAVIANRGVQATYGINEVIE OutC1_Pch ALDASQ---------MSNLPPSTLNLSLTGVMAGDDDSRSIAIISKDNEQFSRGVNEEVP OutC2_Pch ALDASQ---------MSNLPPSTLNLSLTGVMVGDDTARSIAIISKDNEQFSRGVNEEVP OutC_Pca VNDAAL---------SGDIPLTSLNISLTGVLASGDAKRSIAIIAKDSQQYSRNVGDAIP Orf_Kpn P--GGN---------LDQAPVSALRLRVTGLLASTDPSRAIAIMMKGNQQVSLGIGDNTP EtpC_Eco RAQETMP-------SLSDDLLSGEDLDVRGILYSSVAEHSVAIFAHNNRQFSLSVGEKVP XcpP_Pae ---------------NAPPPATNLDLVLKGSFVQSDPKLSSAIIQRQGDKPHRYAVGGEI Orf_Pal ---------------DQAAPATRQQMTLLASFVNPDAKRSTAIIQVAGDKPKRIAVGESV GspC_Bce ---------------------PVQDIHLFGILALDHG--GAAIVSVGGEPPRAVSLGADV GspC_Bps ---------------------PVQDIHLFGILALQRG--AAAIVGIGGDAPHAVSLGSEI Orf_Ccr --------------------SAIDGFRLFGVRSGGPGGGSAIIAGPDGVQKSYAV-GETI Orf_Eco KQPEPV-----------PVAETRLNVVLRGIAFGARP---GAVIEEGGKQQVYLQGETLG Orf_Aae KPSVSS-------------AVSPPSFKVKGIIISERI--RGVILEEGSKDVFLSEGQSFK XcpP_Ppu ------------------IVITRLPLHYLGGLKAQPLS-ASVVVVRYEQQVRTLARGQRL : HtrA_Cmu QTDAAINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVID------Q Orf_Ctr QTDAAINPGNSGGPLLNINGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVID------Q HtrA_Cpn QTDAAINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMANRIID------Q ExeC_Ahy GTQAKIRQVFADRVIIERDGRDETLMLDGEEY---------GKPLPKPGNQ--------D ExeC_Asa GTQAKVRQVFADRVIIERDARDETLMLDGEEY---------GKPLPKQGNP--------D Orf_Vch GTQAKLKAVMPDRVIISNSGRDETLMLEGLDYTAPATASVSNPPRPRPNQPNAVPQF--E OutC1_Pch GYNAKIVSIRPDRVVLQYQGRYEVLGLY--SQ----------EDSGSDGVP--------G OutC2_Pch GYNAKIVSIRPDKVVLQYQGRYEVLGLY--NQ----------EENSADGVS--------G OutC_Pca GYEAKIVTISADRVVLQYQGRYEALHLY--QE----------EEATGAPSS--------S Orf_Kpn GGEAKIIAISPDRLIVNYRGRNEAIPLF--ND----------PPAVGKNSA--------A EtpC_Eco SYDATISAIFSDHIVINYQGKTVSLPLRYDNT----------EKKNAYDNN--------N XcpP_Pae SDGVKLHAVYRDRVELQRGGRLESLPFPHRSG-----------GLLASADD--------I Orf_Pal NVSTRLQAVYQDHVVLDRGGVEESLRFPAVRQ-----------PSLTPA----------Y GspC_Bce TSGAKLAEVRPRSIIVDRNGARAEIQLPANTP-----------SPAIYMR---------- GspC_Bps AQGAKLAEVRDRSIIVERNGARSEIFLPANTP-----------SPAIYVR---------- Orf_Ccr ADGVTLASVAADHVELSRGGARATLSFPVSQ----------------------------- Orf_Eco SHNAVIEEINRDHVMLRYQGKIERLSLAEEERSTVAVTNKKAVSDEAKQAVAEPAVSVPV Orf_Aae GY--KLAKVENDRVIFEKNGVEFPLEFKVTKG----------EKSLTQVNPTLSSLPSEI XcpP_Ppu APGIVLQDIDSDGLIFNNQGRRERLPWPPRPA----------VTGLKRQG---------- : . . : HtrA_Cmu LISDGQVTRGFLGVTLQPIDSELAACYKLEKVYGALITDVVKGSPAEKAGLRQEDVIVAY Orf_Ctr LISDGQVTRGFLGVTLQPIDSELATCYKLEKVYGALVTDVVKGSPAEKAGLRQEDVIVAY HtrA_Cpn LIRDGQVTRGFLGVTLQPIDAELAACYKLEKVYGALVTDVVKGSPADKAGLKQEDVIIAY ExeC_Ahy DKLSSVRSELLGNPGKITDYLNISPVRVDGRMVGYRLNPGSNPELFNQLGLVANDMAVSI ExeC_Asa EKLSSVRSELLGNPGKITDYLNISPVRVDGRMVGYRLNPGSNPELFNQLGLVANDMAVSI Orf_Vch DKVDAIREAIARNPQEIFQYVRLSQVKRDDKVLGYRVSPGKDPVLFESIGLQDGDMAVAL OutC1_Pch AQVNEQLQ--QRASTTMSDYVSFSPIMNDNKLQGYRLNPGPKSDSFYRVGLQDNDMAVAL OutC2_Pch AQLNEQLQ--QRASTTMSDYVSFSPVMNDNKLHGYRLNPGPKSDSFYRVGLQDNDMAVAL OutC_Pca GAFNQVKDEIQKDPFSAQDYLTISPVTEEEVLKGYQLNPGKNPDLFYRAGLQDNDLAVSL Orf_Kpn PPARHLAQELRAQPQNILHYLNISPVMVNDKLSGYRLNPGKDPALFRQSGLRENDLAIAL EtpC_Eco LTVGDVITQDNFRVESVFDIMSFSAVTVNNTLSGYRLIPGKHSSLFYNAGLHDNDLAVSV XcpP_Pae TSENDSIEQLQSLQDENAAALRERLDALRQQMEATPIAEPAEEDSSEPTTTPTESD---- Orf_Pal SALEPTASQLEQLQDEDVQALQERIQTLQQRMEGGDIPQPEIPEAEDSP----------- GspC_Bce ------------------------------------------------------------ GspC_Bps ------------------------------------------------------------ Orf_Ccr ------------------------------------------------------------ Orf_Eco EIPAAVRQALAKDPQKIFNYIQLTPVRKEG-IVGYAAKPGADRSLFDASGFKEGDIAIAL Orf_Aae VVSRREILELTKDPAKMFTQIRLVPYIKNGKTEGFIFEWVKPGSLFYKLGLRRGDILVSI XcpP_Ppu ------------------------------------------------------------ HtrA_Cmu NGKEVESLSALRNAISLMMPGTRVVLKVVREGKFIEIPVTVTQIPAEDGVSALQKMGVRV Orf_Ctr NGKEVESLSALRNAISLMMPGTRVVLKIVREGKTIEIPVTVTQIPTEDGVSALQKMGVRV HtrA_Cpn NGKEVDSLSMFRNAVSLMNPDTRIVLKVVREGKVIEIPVTVSQAPKEDGMSALQRVGIRV ExeC_Ahy NGLDLRDNAQAMQAMQQVAGATEMTVTVERQGQLYDVYVGLSE----------------- ExeC_Asa NGLDLRDNAQAMQAMQQVAGATEMTVTVERQGQLYDVYVGLSE----------------- Orf_Vch NGLDLTDPNVMNTLFQSMNEMTEMSLTVERDGQQHDVYIQF------------------- OutC1_Pch NGLDLRDAEQAKKAMERMADVHNFTLTVERDGQRQDIYMEFGGDE--------------- OutC2_Pch NGLDLRDEEQAKKAMERMADVHNFTLTVERDGQRQDIYMEFGGDE--------------- OutC_Pca NGMDLRDADQAQQAMAQLAGMSKFNLTVERDGQQQDIYLALDGDH--------------- Orf_Kpn NGLDLRDKEQARQVLAQLPELTEITLTVERDGQKNDIYLALRDE---------------- EtpC_Eco NGSELRDTRQAQQIMKQLPELKEIKITVERDGQLYDAFIAVGEN---------------- XcpP_Pae ------------------------------------------------------------ Orf_Pal ------------------------------------------------------------ GspC_Bce ------------------------------------------------------------ GspC_Bps ------------------------------------------------------------ Orf_Ccr ------------------------------------------------------------ Orf_Eco NQQDFTDPRAMIALMRQLPSMDSIQLTVLRKGARHDISIALRYRLFCPPYWKKS------ Orf_Aae NNTTIRSGEDAFRILQMIRNEPNLKVELIRRGKREEINVRIE------------------ XcpP_Ppu ------------------------------------------------------------ HtrA_Cmu QNLTPEICKKLGLASDTRGIFVVSVEAGSPAASAGVVPGQLILAVNRQRVSSVEELNQVL Orf_Ctr QNITPEICKKLGLAADTRGILVVAVEAGSPAASAGVAPGQLILAVNRQRVASVEELNQVL HtrA_Cpn QNLTPETAKKLGIAPETKGILIISVEPGSVAASSGIAPGQLILAVNRQKVSSIEDLNRTL ExeC_Ahy ------------------------------------------------------------ ExeC_Asa ------------------------------------------------------------ Orf_Vch ------------------------------------------------------------ OutC1_Pch ------------------------------------------------------------ OutC2_Pch ------------------------------------------------------------ OutC_Pca ------------------------------------------------------------ Orf_Kpn ------------------------------------------------------------ EtpC_Eco ------------------------------------------------------------ XcpP_Pae ------------------------------------------------------------ Orf_Pal ------------------------------------------------------------ GspC_Bce ------------------------------------------------------------ GspC_Bps ------------------------------------------------------------ Orf_Ccr ------------------------------------------------------------ Orf_Eco ------------------------------------------------------------ Orf_Aae ------------------------------------------------------------ XcpP_Ppu ------------------------------------------------------------ HtrA_Cmu KNAKGENVLLMVSQGEVIRFVVLKSDE Orf_Ctr KNSKGENVLLMVSQGDVVRFIVLKSDE HtrA_Cpn KDSNNENILLMVSQGDVIRFIALKPEE ExeC_Ahy --------------------------- ExeC_Asa --------------------------- Orf_Vch --------------------------- OutC1_Pch --------------------------- OutC2_Pch --------------------------- OutC_Pca --------------------------- Orf_Kpn --------------------------- EtpC_Eco --------------------------- XcpP_Pae --------------------------- Orf_Pal --------------------------- GspC_Bce --------------------------- GspC_Bps --------------------------- Orf_Ccr --------------------------- Orf_Eco --------------------------- Orf_Aae --------------------------- XcpP_Ppu ---------------------------