CLUSTAL X (1.81) multiple sequence alignment Eco1 ------------------------------------------------------------ Sfl1 ------------------------------------------------------------ Sen1 ------------------------------------------------------------ Sty1 ------------------------------------------------------------ Vvu1 ------------------------------------------------------------ Vch1 ------------------------------------------------------------ Pmu1 ----------------------------------------------------MLIPRFLG Sen2 ------------------------------------------------------------ Sty2 ------------------------------------------------------------ Eco2 ------------------------------------------------------------ Spy1 ------------------------------------------------------------ Sag1 ------------------------------------------------------------ Spn1 ------------------------------------------------------------ Smu1 ------------------------------------------------------------ Lme1 ------------------------------------------------------------ Efac2 ------------------------------------------------------------ Cpe1 ------------------------------------------------------------ Oih1 ------------------------------------------------------------ Mpe2 ------------------------------------------------------------ Mpu2 ------------------------------------------------------------ Sag2 ------------------------------------------------------------ Spn2 ------------------------------------------------------------ Lpl2 ------------------------------------------------------------ Efa1 ------------------------------------------------------------ Efac1 ------------------------------------------------------------ Lpl1 ------------------------------------------------------------ Vvu2 ------------------------------------------------------------ Vpa1 ------------------------------------------------------------ Eco3 ------------------------------------------------------------ Ype1 ------------------------------------------------------------ Sty3 ------------------------------------------------------------ Sen3 ------------------------------------------------------------ Sau1 ------------------------------------------------------------ Spy2 ------------------------------------------------------------ Cgl1 ------------------------------------------------------------ Sco1 ------------------------------------------------------------ Efa2 ------------------------------------------------------------ Lmo2 ------------------------------------------------------------ Lin1 ------------------------------------------------------------ Lmo1 ------------------------------------------------------------ Bha1 ------------------------------------------------------------ Tte1 ------------------------------------------------------------ Mpu1 --------------------------MTQKLNKSKKIGFWVGVGIFVLINLIIIAITLGI Mpn1 --------------------------MLNKIKLQQKRKLIIGWSVFALINLVVILLTVLL Mpe1 MSQNLDLKNSETPDISTTSEELSEKKKKWKFKDHWKSILAWSLVVLVIVLGYVIVAAVGA Eco1 --MHNIPGVWNTRLPLLQEIVMEILYNIFTVFFNQVMTNAPLLLGIVTCLGYILLRKSVS Sfl1 --MHNIPGVRNTRLPLLQEIVMEILYNIFTVFFNQVMTNAPLLLGIVTCLGYILLRKSVS Sen1 ----------MTQQPYLPEIVMEILYNIFTIFFNQVMTNAPLLLGIVTCLGYILLRKSVS Sty1 ----------MTQQPRLPEIVMEILYNIFTIFFNQVMTNAPLLLGIVTCLGYILLRKSVS Vvu1 ---------------------MEFLYDIFYIFYSQVMTKAPLLLGLVTLIGYWLLRRDTT Vch1 ---------------------MEFLYDVFYIFYSQVMTKAPLLLGLVTLIGYWLLRRDAT Pmu1 SGLIQKSFMQIYTMKKSRGVTMETLYNLFLSFNNQVLSKAPFLLGIVACIGYILLKKDTT Sen2 ------------------MEGVQTMFAKFIDVIQTFLTEPAILIGILVGVGYALDKKTPI Sty2 ------------------MEGVQTMFAKFIDVIQTFLTEPAILIGILVGVGYALDKKTPI Eco2 ------------------MEGVPTMFAKFIDVIQTFLTEPAILIGLLVGIGYALDKKSPI Spy1 ---------------------MEMLLAPLNWFSQNILQNPAFFVGLLVLIGYLLLKKPIY Sag1 ---------------------MENFLAPLNWFSQNILQNPAFFVGLLVLIGYLLLKKPLH Spn1 ---------------------MEVVSSVLNWFSSNILQNPAFFVGLLVLIGYALLKKPAH Smu1 ---------------------MNILINILTWFSQNILQKPAFFVGILVLIGYLLLKKPLH Lme1 -----------------MDSILAGILKIWEFFADNILTQPAYMIGFIVLIGYMLEKKPWY Efac2 --------------------MGEFLLNSWTYFATNVLTQPAYLIGFIVLLGYLLLRRPFY Cpe1 -------------------------MKEILDFCVSFFRNPALFMGLVVAIGLILQRKPID Oih1 -------------------------MESVMNFVIEIIREPAIFLGLIALTGLLLLKKDIS Mpe2 ---------------------------MVLSLFRDFVGTPAILVGLFAMLGAILLRKKAT Mpu2 ------MINNIGVTMRFLASLEPTTSEYFINFFKQFIGTPAILIGLFTLIGCALQRKKIT Sag2 -------------------------MKGLLDFLVNIASTPAILVALIAIIGLVLQKKGVP Spn2 ----------------------------MMKFILDIVSTPAILVALIAILGLVLQKKKLP Lpl2 -------------------------MQATLNAIISIVRTPAILVGLIAILGQALQKKSFS Efa1 -------------------------MDKLLNLFVSIVSQPSILVSLIALLGLVLQKKKFS Efac1 -------------------------METLLNLFVSIVSQPAILVSLIALLGLVLQKKKFS Lpl1 -------------------------MKTVLNLFVGIVTQPSILVALIAMLGLLLQKKKST Vvu2 --------------------------------MNDVLSEPAVLVGLIALIGLIAQKKPVT Vpa1 -------------------------MEFFSFLMNDVLSEPAVLVGLIALIGLIAQKKPVT Eco3 -------------------------MDFFRFLMSDVLSEPAVLVGLIALIGLIAQKKPVT Ype1 -------------------------MDFFRFLMSDVLSEPAILVGLIALIGLIAQKKPVT Sty3 -----------------------MFILETLNFVVDILKVPSVLVGLIALIGLVAQKKAFS Sen3 -----------------------MFILETLNFVVDILKVPSVLVGLIALIGLVAQKKAFS Sau1 -------------------------MQAILNFIVDILSQPAILVALIAFIGLIVQKKPAA Spy2 -------------------------MEALLSFIRDILKEPAFLMGLIAFAGLVALKTPAH Cgl1 ----------------------MDWLTIPLFLVNEILAVPAFLIGIITAVGLGAMGRSVG Sco1 ---------------------MDWVIDTAKFLVNEILSQPAYLIGIITAVGLAALKKSVG Efa2 -------------------------MGVINFIIENILTQASITIALIAMLGLLLQKKSAG Lmo2 ----------------------------MLTFITEIFSTPAFILGIIAAIGLIALRKTGS Lin1 -------------------------MEIITWIANNFFGTPAILLGFIVLLGLLLQKKNLS Lmo1 -------------------------MEIITWIANNFFGTPAILLGFIVLLGLLLQKKNLS Bha1 ------------------------MFQMVEWVASNVFGEPAILLGFIVLLGLVLQKKGFS Tte1 -------------------------MWLIDFLVKNIFNQVAVLIGLVTLIGLVLQKKSFE Mpu1 RMSKE----------KPDTYGAASLFLLKNVYLDNFFGQPALLLGFLTLIGYLILGRGAR Mpn1 RAGLPNLVSKGVTPFSAQAFGDAFIFLITRVYLDNFLRQPALLLGVITLIGYLALGRGGV Mpe1 PEYKNGTKVIAAVAGNFRDAGNAFTWYLNAVWIDNFLGVPAILLAVLSFIGYIVLKRGFV . . :... * Eco1 VIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYG--------INGAISDTYASMM Sfl1 VIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYG--------INGAISDTYASMM Sen1 VIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYG--------INGAISDTYASMM Sty1 VIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYG--------INGAISDTYASMM Vvu1 TIIKGSIKTIVGFMLVQVGAGTLVAGFKPVISKLSEFHG--------LTGSVIDPYTSMM Vch1 TIIKGSIKTIVGFMLVQVGAGTLVAGFKPVIEKLSQYHG--------LTGSVIDPYTSMM Pmu1 TVIKGTIKTIVGFMIVQAGSGFLVANFKPIIEGLSKYHN--------LTGAVIDPYTSMQ Sen2 KIITGMISAMVGLMMVLFGGFQFSATFKPVAEAVSKAYG--------VHGYLMDSYAMKA Sty2 KIITGMISAMVGLMMVLFGGFQFSATFKPVAEAVSKAYG--------VHGYLMDSYAMKA Eco2 KIITGMVSAMVGLMMVLFGGFQFSATFKPVAEAVSKAYG--------VHGYLMDSYAMKA Spy1 EVFAGFVKATVGYLILNVGAGGLVTTFRPILVALAKKFE--------LKAAVIDPYFGLA Sag1 DVFAGFIKATVGYLILNVGAGGLVNTFRPILVALAKKFN--------LEAAVIDPYFGLA Spn1 DVFSGFVKATVGYMLLNVGAGGLVTTFRPILAALNYKFQ--------IGAAVIDPYFGLA Smu1 DVFAGFIKATVGYMILDVGAGGLVTTFRPILAALNYKFK--------IGAAVIDPYFGLT Lme1 ESLAGFLKATIGYMILIVGSNGLVTSFRPILTGLKDRFH--------LTATVIDPYFGQN Efac2 ECLAGFLKATVGYFILSVGSGGLVNNFRPILVGLKERFN--------LQAMVTDPYFGQN Cpe1 AILKGIFKGIIGMVILLKGVDIVVSSITPLANAFSGLFN--------TQSNSTLGDFN-- Oih1 TIVSGTAKTIIGVVILTQGTNILVSSIEPLTAGFNLMYD--------IQETEVNPALGSD Mpe2 EIITTFFKTAAGFLIVTGGATVISGALTNFQALFTDLFN--------INGIIPNNDAFAG Mpu2 EIITSTIKTIIGFIIIGAGAGFLASAVAKLGSAFNLLLG--------VSGVISNNDSVPG Sag2 DIVKGGIKTFVGFLVVSGGTGIVQNSLNPFGKMFEHAFH--------LVGVVPNNEAIVA Spn2 DIIKGGIKTFVGFLVVSGGAGIVQNSLNPFGTMFEHAFH--------LSGVVPNNEAIVA Lpl2 DTVSSGIKTFIGFLVLSGGAGIVSTSLAPMSKMFMHAFG--------VQGVVPNNEAVVA Efa1 EVIQGTIKTFVGFLVLIGGAGLISNSLTPFASMFQTALH--------TQGVVPSNEAVVA Efac1 DVVQGTLKTFVGFLVLIGGAGLLANSLTPFAEMFQTALN--------TQGVVPSNEAVVA Lpl1 EVVQGTIKTFAGFLVLTGGAGILQNALSPFASMFKFALH--------VQGVVPSNEAVVA Vvu2 ECIKGTVKTILGFIILGAGAGLVVSSLGDFATIFQQAFG--------ITGVVPNNEAIVS Vpa1 ECIKGTVKTILGFIVLGAGAGLVVSSLGDFATIFQHAFG--------ITGVVPNNEAIVS Eco3 ECIKGTVKTIMGFVILGAGAGLVVSSLGDFANIFQHAFG--------IQGVVPNNEAIVS Ype1 ECIKGTVKTIMGFVILGAGAGLVVSSLGDFANIFQQAFG--------IQGVVPNNEAIVS Sty3 DVVKGTIKTILGFIVLGGGATVLVGSLNPLGGMFEHAFN--------IQGIIPNNEAIVS Sen3 DVVKGTIKTILGFIVLGGGATVLVGSLNPLGGMFEHAFN--------IQGIIPNNEAIVS Sau1 TITSGTIKTILGFLILSAGADVVVRSLEPFGKIFQHAFG--------VQGIVPNNEAIVS Spy2 KVLTGTLGPILGYLMLAAGAGVIVTNLDPLAKLIEHGFS--------ITGVVPNNEAVTS Cgl1 QVIGGAIKATLGFLLIGAGATLVTASLEPLGAMIMGATG--------MRGVVPTNEAIAG Sco1 QTVGGAIKATLGLLLVGAGAGLVSSSLDPLGRMIQGTTG--------THGVIPTNEAIVG Efa2 QVISGTLKTLLGFQVLSAGSSIIVGSLTYFGKIFTEGFH--------MQGIIPSIESING Lmo2 DIVKGTLKTIFGFIMLQQGSAIIVGSLIPFSTMFENAFQ--------LKGVVAEDNAIAA Lin1 QVISGTFKAIIGFLIINAGAAVITGSLGIFEPMWKEVFG--------LETPPLAGFLGQE Lmo1 QVISGTFKAIIGFLIINAGAAVITGSLGIFEPMWKEVFG--------LETPPLAGFLGQE Bha1 KTVSGTFKAIIGFLIIDAGAGVIVGALNVFEPMWKEVFN--------LQDQPLGQFMGQE Tte1 DTISGTIKSMVGILIMLAGVDVFIGGLVSFQTIVSSAFH--------ISPPTAQNTLQN- Mpu1 DSIVGSLKTIIGVLLLNIGSGVLVSMARPVFNAISQIAGSSAKSSAQIVPLDPYFGLSSS Mpn1 QSVVGALKTVIGFILLSIGSGVLVSTARPVFDTIKGLGG------TGVVLLDPYFSLASA Mpe1 DSLIGALKTAIGVLLLNVGSTALSGIASPLFNGFRSWGG------ATVVPLDPYQGWNSG * :: * . . Eco1 AT----IDRMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTG-HIMFQQAGLIAV Sfl1 AT----IDRMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTG-HIMFQQAGLIAV Sen1 AT----IERMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTG-HIMFQQAGLIAV Sty1 AT----IERMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTG-HIMFQQAGLIAV Vvu1 ST----METMGDNYSWVGYTVLLALGINILLVLFRRYTGIRTIMLTG-HIMFQQAGLIAV Vch1 AT----METMGDNYSWVGYAVLLALAINILLVLFRRYTGIRTIMLTG-HIMFQQAGLIAV Pmu1 AT----IQTMADNYAWVGYAVILALFLNILLVVCRRITGIRTIMLTG-HIMFQQAGLVAV Sen2 AT----QIALGDNFGYVGYVFVLAFFTNLILVLFGRYTGAKGIFLTGNTGVSHSQAVLWL Sty2 AT----QIALGDNFGYVGYVFVLAFFTNLLLVLFGRYTGAKGIFLTGNTGVSHSQAVLWL Eco2 AT----QIALGDNFGYVGYVFVLAFFTNLLLVLFGRYTGAKGIFLTGNTGVSHSQAVLWL Spy1 AANTKLEEMG--FISVATTALLIGFGVNILLVALRKVTKVRTLFITG-HIMVQQAATISV Sag1 SANAKLETMG--FISVATTALLIGFGINILLVALRKVTKVRTLFITG-HIMVQQAATISV Spn1 AANNKIVAEFPDFVGTATTALLIGFGINILLVALRKITKVRTLFITG-HIMVQQAATVSL Smu1 AANEKIAQEFPRFIGTATTALLIGFFFNILLVALRKITKIRTLFITG-HIMVQQAATVTL Lme1 AVTDGLEKTFGRSFGDVMILLLIAFVFNILLVRFSKYTKLRAVFTTG-NVQVQQAATAFW Efac2 AVDAGLMKTFGRTFGDVMILLLIAFIMNILLVRFQKYTKLRAVFTTG-NVQIQQAATAFW Cpe1 VFLGQYGSYV-------G---LILLCGFVINIIIARYTRFKTIYLTGNILFWYPMLFLAV Oih1 QVLSQYGTQI-------G---IAMLAAFAINLLVARFTKIKHVFLTGHMLFWFPFIFVAV Mpe2 WFFSNYAAIS-------QLGSIVMVVAMILNLILAYTSRFKYIFLSGHVLFYMSVMLSGV Mpu2 IFLENLSHLV-------LAGSLIMIVAMFLNILLARITNLKYIYLSGHVLFYMSVMLASV Sag2 VALTKYGS---------ATALIMLAG-MIFNILIARFTKFKYIFLTGHHTLYMACMIA-- Spn2 VALTTYGS---------ATAMIMFAG-MVFNILIARFTRFKYIFLTGHHTLYMACMIA-- Lpl2 TVLVEYGT---------ATALIMLVS-MIVNVILARFSHFKYIYLSGHVMLYMAAMLA-- Efa1 IALQQYGT---------PTALIMLVG-MIVNILLARFTRYKFIFLTGQAMLYVSCLTA-- Efac1 IALQQYGT---------PTALIMLVG-MVVNILLARFTRFKYIFLTGQAMMYVSCLTA-- Lpl1 IALVKYGS---------TTALIMLAG-MIVNILLARFTRFKYIFLTGQAMLYVSCLTA-- Vvu2 IAQEAFGK---------EMAMIMFFA-MLVNILIARFTPWKFIFLTGHHTLFMSMMVA-- Vpa1 IAQEAFGK---------EMAMIMFFG-MLVNILIARFTPWKFIFLTGHHTLFMSMMVA-- Eco3 VAQKSFGK---------EMAMIMFFA-MVINIMIARFTPWKFIFLTGHHTLFMSMMVA-- Ype1 VAQKSFGK---------EMAMIMFFA-MVINILIARFTPWKFIFLTGHHTLFMSMMVA-- Sty3 IALEKYGA---------STALIMAFG-MVANIVVARFTRLKYIFLTGHHTFYMACMIG-- Sen3 IALEKYGA---------STALIMAFG-MVANIVVARFTRLKYIFLTGHHTFYMACMIG-- Sau1 LALKDFGT---------TAALIMVCG-MIVNILIARFTNLKYIFLTGHHTFYMAAFLA-- Spy2 VAQKILGV---------ETMSILVVG-LLLNLAFARFTRFKYIFLTGHHSFFMACLLS-- Cgl1 IAQAEYGA---------QVAWLMILG-FAISLVLARFTNLRYVFLTGHHVLFMSTMLT-- Sco1 IAQSEFGA---------RVAWLMILG-FLVSLALARFTPLRYVFLTGHHMLFMATLLT-- Efa2 QAMNDLGLGR-------DIALTFLAI-FVFNIILARFTKWKYIFLTGQAILWMATMTT-- Lmo2 AVQQILGT---------ETSLILVFG-FIINVILARTTRWKYIFLTGHMMFSFAATMA-- Lin1 AFNAKFGS---------AVTLAMTLG-FLVNVLLARFTPFKYIYLTGHMMFWTTTIFAGI Lmo1 AFNAKFGS---------AVTLAMTLG-FLVNVLLARFTPFKYIYLTGHMMFWTTTIFAGI Bha1 GFNAQYGS---------AVTLAFFFG-FVINVLLARFTKMKFIYLTGHMMFWTATIFAGI Tte1 -FTNNFGS---------VAVSIMALG-FLIHLLIVRIFNTGFVYLTGHLMWWISLVIS-A Mpu1 QNFLQNFVVGNNYVTWVSYVFMIAFAINIILILLKRWTNVHSLMVTGHIMYQQSAIIVVV Mpn1 NDFFTNSFLNNDYVSLIAFSLLVGFIVNIIFVGLKRWTNTNSIMVTGHVMLQQAAVVTTL Mpe1 LNFLTSFATGNNYTSWVSYALLVGFAFNILLVSLRRWTNCHAVMTTGHIMFQQSAVVVPF : : :* Eco1 TLFIFG---YS-----------MWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSI Sfl1 TLFIFG---YS-----------MWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSI Sen1 SFYIFG---YS-----------MWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSI Sty1 SFYIFG---YS-----------MWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSI Vvu1 FYFVLG---TS-----------MWETIIYSAVLMALYWGISSNIMFKPTEEVTGGAGFSI Vch1 FYFVLG---AG-----------MWETIIYSAVLMALYWGISSNIMFKPTEEVTGGAGFSI Pmu1 FYMIIG---AS-----------MWETVIYTAVLMALYWGISSNIMYKPTQAVTGGAGFSI Sen2 IVFWLG---FG-----------WVQSIVIAGVLTGVFWAFSTTLIVKPIAKVTNNAGFTI Sty2 IVFWLG---FG-----------WVQSIVIAGVLTGVFWAFSTTLIVKPIAKVTNNAGFTI Eco2 IVFWLG---FS-----------WTTSIIIAGILTGVFWAFSTTLIVKPIAKVTKDAGFTI Spy1 FVLLLIPQFQN-----------AFG-AWAVGIICGLYWAVSSNMTVEATQRLTGGGGFAI Sag1 FVLLLIPQLRN-----------GFG-AWAVGIICGLYWAVSSNMTVEATQRLTGGGGFAI Spn1 MVLFLVPQLRN-----------AYG-TAAIGIICGLYWAVSSNMTVEATQRLTGGGGFAI Smu1 MVILLIPAFRN-----------QFWGTLAVGIICGLYWAVSSNMTVEPTQRLTGGGGFAI Lme1 ILLFAIPSLG------------RIEVLLVMGVLLGLYWAVGSNMTIKATQQLTDGGGFAI Efac2 ILLFCFPNLG------------RIEVLIFMGLILGCYWAVASNLTVGITQELTEGAGFAV Cpe1 GIEN------NVS---------GLKLFIFTLIMYILVITIFPYILRKHVKYVTGNDSFTI Oih1 GVEN------NLS---------NVQLIIFASIMTALYIIIAPALLRPFVRKVTGSDDFII Mpe2 MILSGLDVNTVGG---------YAVALISSSTILSVYMVLSCAMLYKWTKQITKVDTITV Mpu2 FYVGGLDKEVD-----------IPIIVISGSLILSLWMIISPAFLNKYVVQITNSNDIAI Sag2 VIFAVAGFTS-------------FSLILFGGLALGIIMSVSPAFVQKYMIQLTGNDKVAL Spn2 VILSVAGFTS-------------LPLILLGGLALGIIMSISPAFVQKYMVQLTGNDKVAL Lpl2 VIMQVAGFGF-------------ATEVLFGGLILGIWDTVSPALVQPFLREVTGGNTVAL Efa1 VILVSAGFTAN------------LWMILLGGVFEGTLLTITPALCQPFMKNITGNNQVAL Efac1 VILVGAGFSVS------------LPMILLGGLFEGTLLTVTPALCQPFMKQITGNDKVAM Lpl1 VILVSANIGTG------------WQTIVLGGLFEGTLLTVTPALTQPFMRKITGGDDVAM Vvu2 AILSSSGMSG-------------VPLIALGSLVVGSVMVFFPAIAHKYMKQVTGSDDVAI Vpa1 AILASSGMKG-------------VPLIALGSVVVGSVMVFFPAIAHKYMKQVTGSDDVAI Eco3 VILATAGMTG-------------ITLIAVGSLVVGVAMVFFPAIAHPYMKKVTGSDDVAI Ype1 VILATAGLSG-------------MMLIAIGSVVVGVAMVFFPAIAHPYMKKVTGSDDVAI Sty3 VILTVAGFEG-------------VGLVFTGSLILGLVMAFFPALAQRYMRRITGTDDIAF Sen3 VILTVAGFEG-------------VGLVFTGSLILGLVMAFFPALAQRYMRRITGTDDIAF Sau1 IILTVSHIKG-------------WLTIVIGALVLGLIMAVLPALLQPTMRKITGNDQVAL Spy2 AVLGAVGFKG-------------SLLIILGGFLLGAWSAISPAIGQQYTLKVTDGDEIAM Cgl1 IILATAGFDA-------------WIVVGVGALLLGILMVSLPAFAHPWTRRITGDDSIAI Sco1 IVMATAGQGS-------------VAVVLGGGVLVGILLVALPAFAHPWTKKVTGNDTLAI Efa2 VFGYFAGLRG-------------IVLILVGGFIGACFAIAMPAVAQPIIRKITGSNDIAL Lmo2 IVFDQMGFNS-------------WQIILFGSIAQGISSIVFPALAQPFVRKVTGNDQVGF Lin1 TVQAVGGDIPF------------WGLVLFLAVIMGLYWTLQPAITQPFLRKITGNDNVAL Lmo1 TVQAVGGDIPF------------WGLVLFLAVIMGLYWTLQPAITQPFLRKITGNDNVAL Bha1 IIHTVG-DVPY------------WKLVTFLAIFLGVYWTVQPAIIQPFMRKVMGHDNIAL Tte1 SLLEVFPRINQ------------GVLILVGSILIALYWTFQPMYVHKYMKKVTNSDEIGY Mpu1 VYALLFRDVPLLSNNGGVSVGTQVGVVLISSLLLGAYWGVGSTATIKATDKVTQNAGFAV Mpn1 FYIVLFRQIPLLG--TGIAYGAQAGLVIISGIFLGVYWSTASTGTYLVTNKVTNNAGFSI Mpe1 VYLLFFANTALSGG-SIVEPSVEVGTVLFAGIFLGSYWSVGTTMTIKATNKITENANFAI : . Eco1 GHQQQFASWIAYKVAPFLGKKE----------ESVEDLKLPGWLNIFHDNIVSTAIVMTI Sfl1 GHQQQFASLIAYKVAPFLGKKE----------ESVEDLKLPGWLNIFHDNIVSTAIVMTI Sen1 GHQQQFASWIAYKVAPFLGKKE----------ESVEDLKLPGWLNIFHDNIVSTAIVMTI Sty1 GHQQQFASWIAYKVAPFLGKKE----------ESVEDLKLPGWLNIFHDNIVSTAIVMTI Vvu1 GHQQQVASWIATKVAPKLGDKN----------DSVDHLELPKWLHIFHDSIAATAIVMTV Vch1 GHQQQVASWIATKIAPKLGDKK----------DSVDHLQLPKWLHIFHDSIAATAIVMTV Pmu1 GHQQQIASWIAVKLAPKLGDKN----------DTVDKMKLPKWLHIFHDSISATALVMTV Sen2 AHNQMLGLWFFSKFAHKFGDPEK---------HDAENLKLPGWLAIFNHNVTAIAIVMTL Sty2 AHNQMLGLWFFSKFAHKFGDPEK---------HDAENLKLPGWLAIFNHNVTAIAIVMTL Eco2 AHNQMLGLWFFSKFAHKFGDPEK---------HDAENLKLPGWLAIFNHNVTAIAIVMTL Spy1 GHQQQFAIWFVDKVAPFFGKKE----------ENLDNLKLPTFLNIFHDTVVASATLMLV Sag1 GHQQQFAIWFVDKVAPFFGKKE----------ENLDNLKLPTFLNIFHDTVVASATLMLV Spn1 GHQQQFAIWFVDKVAGRFGKKE----------ESLDNLKLPKFLSIFHDTVVASATLMLV Smu1 GHQQQFAIWFTDKIAPKLGKKE----------ENLDNLKLPAFLNIFHDTVVASATLMLV Lme1 AHQQMFGIALVAWISDKMKKSSDKSK--TKSAKRLEDITLPGFLRIFNENMVATAILMFL Efac2 AHQQMFGIFIFAKLAEWLKKRDQKKHRSEKVDKKLEDIELPGFLSIFNENMVATSILMLF Cpe1 GHTASIYCLLGSYIGKLVGQKDK----------NIENLNLPKSLSFFRDTNITAAIVMFI Oih1 GHPTTILSLIAGGVGKLFGTKGR----------SSEDIKFPKSTEFLREISITSSITMFL Mpe2 AHTGSLSYLMGGLIGELVYKIKK--G---KNIKSTEDIKFPKGLQFFRNTFISMAITMLV Mpu2 AHTGSLAYLFSAWVGLGVAKVHKKLN---KKIVSTEDIKFPKTLSFLRNTNVAIAITMFF Sag2 GHFGSLGYWLSGFIGGIVG----------DKSKSTEDIKFPKSLSFLRDSTVSITISMAI Spn2 GHFSSLGYWLSGFTGSLIG----------DKSKSTEDIKFPKSLAFLRDSTVSITLSMAV Lpl2 AHTGDFGYAFAGLIAKFTG----------DKRKSTEDLNIPKSVSFLRDSTVAITITMAV Efa1 GHTGNIGYASSGWIGKFFG----------NKDRSTEDIKIPKSFSFLRDSTVSIMLLMSI Efac1 GHTGNIGYAASGFIGKVFG----------NKEKSTEDIKIPKSFGFLRDSTISIMILMSI Lpl1 GHTGNIGYALSGLMGKWFG----------NAEKSTEDLEIPKSLGFLRDSTVSITILMGI Vvu2 GHFSTLSYVLAGFIGSKFG----------NKEHSTEEMNVPKSLLFLRDTPVAISFTMGI Vpa1 GHFSTLSYVLAGFIGSKFG----------NKEHSTEEMNVPKSLLFLRDTPVAISFTMGI Eco3 GHFSTLSYVLAGFIGSKFG----------NKEHSTEDMNVPKSLLFLRDTPVAISFTMSI Ype1 GHFSTLSYVLAGFIGSKFG----------NKEHSTEDMNVPKSLLFLRDTPVAISFTMCI Sty3 GHFGTLGYVLSGWIGSLCG----------KGSRSTEEMNLPKNLSFLRDSSISISLTMMI Sen3 GHFGTLGYVLSGWIGSLCG----------KGSRSTEEMNLPKNLSFLRDSSISISLTMMI Sau1 GHFGSISYFAAGAVGQLFK----------GKSKSTEEIKFPKGLSFLRESTISISITMAL Spy2 GHFGSLGYYLSAWVGSKVG----------KDSKDTEDLQISEKWSFLRNTTISTGLIMVI Cgl1 GHFGTAGYVAAGAVGRLVGGKGK------KASPSTEDMKVPEGLRFLRDSMVSTALSMAI Sco1 GHFGTAGYIVSGATGQLVG----------KNSRSTEEMKLPEGLRFLRDSMVATALSMVL Efa2 GHFCTIGYLFEAGVAKLFGEKG-------ENKKSIEDIKLPTHFEFLQDTYLSVMVVMVP Lmo2 GFWGSSLVWATGWLGGKLG----------NKANSTEDLKVPKKLDFLKEMSVLMGIVMAV Lin1 GHTSSSVAILSALLGKVFG----------NKKNDAEHINLPKKLEFLRDSNVITALTMGI Lmo1 GHTSSSVAILSALLGKVFG----------NKKNDAEHINLPKKLEFLRDSNVITALTMGI Bha1 GHTSASVALIAALLGKVVG----------NKENDTEKIQLPKGLEFLRDSNVITALTMGI Tte1 GHTSSIAAYLAGRFGHLLG----------KPEESTEKMKVPKKIEFMKD------ITVGT Mpu1 GHQQMLAISLSYKIGKYFGKEEE----------TAENRKLPKYLSIFEDNIFTQTVLISI Mpn1 GHQQMLGIMTVAKLGKYFGDKND----------SAEHKKLPKALKIFEDNIFTQTIIILS Mpe1 GHQQMMGITAAFHLGRFFKFTKKG-----QEVVSAENRKLSKKFRIFEDNIFVQSVLIIL .. . :. .. ::.. : Eco1 FFGAILLSFGIDTVQA----------------------------MAGKVHWTVYILQTGF Sfl1 FFGAILLSFGIDTVQA----------------------------MAGKVHWTVYILQTGF Sen1 FFGAILLSFGIDTVQA----------------------------MAGKVHWTVYILQTGF Sty1 FFGAILLSFGIDTVQA----------------------------MAGKTHWTIYILQTGF Vvu1 FFGIILLSFGLDNLQA----------------------------MAGGTHWSIYILETGL Vch1 FFGIILLSFGLDNLQE----------------------------MAGSTHWTIYILETGL Pmu1 FFGIILLSFGLDNLQQ----------------------------MAGKTHWFMYIFEMGL Sen2 FVGGFLLATGIDNVQL----------------------------MAKGKPWYIYIINLGL Sty2 FVGGFLLATGIDNVQL----------------------------MAKGKPWYIYIINLGL Eco2 FVGGFLLSTGIDNVQL----------------------------MAKGKPWYIYIINLGL Spy1 FFGAILAVLGPDIMSDVGLIGPG-------------------AFNPAKQAFFMYILQTSL Sag1 FFGGILAVLGPDIMSNVKLIGPG-------------------AFVPTKQAFFMYILQTSL Spn1 FFGAILLILGPDIMSNKEVITSGT------------------LFNPAKQDFFMYIIQTAF Smu1 FFGAILAILGPDIMSNPKVITTGT------------------LFDPTKQAFFMYVVQTAF Lme1 FFGIIMVVLGENYFHQLFITSKGT------------------SGLAQGTSFFFYILTTSL Efac2 FFGIILLVLGQDYLIQAKFMQE-------------------------GQSFFFYIMTTSL Cpe1 VYIIVGLFIGKESRIAIYGSEP----------------------------LITYSLIQGI Oih1 VYLVVSIIIGFDTATEAFAAEQN---------------------------LFIYSLMQGV Mpe2 VYLIVYVPQGIMYQTGIKLLSANNPNYDI---------INDLFKPGAATNWIVKCIIEAF Mpu2 IYLIIYIAAWIAKGYQGLVLSG---------------------VIASQDDVIVQGLLQAF Sag2 IYLIVAVFAGE---------------------------AYIAKEISNGVNGLVYALQLAG Spn2 IYIIVAIFAGS---------------------------EYIEKEISSGTSGLVYALQLAG Lpl2 IYIILALFAGP---------------------------EFVG-KMSSGMNYIVFALIQAG Efa1 VYVALALLAGP---------------------------GFVERELSNGDNAVIFALIQAG Efac1 VYVILALLAGT---------------------------GYVEHELSNGENAIIFSLIQAG Lpl1 VYIILAIVTGP---------------------------AYIESKLSGGTNYIVYALVQAG Vvu2 IFMVTCLFAGG---------------------------DFVREVS-GGKHWFMFALMQSI Vpa1 IFMVTCLFAGG---------------------------DFVREVS-GGKHWSMFALMQSI Eco3 IFLVTCLFAGA---------------------------DAVKELS-GGKNWFMFSIMQSI Ype1 IFVVTCLFAGP---------------------------EVVKSLS-GGKNWFMFSLMQSI Sty3 IYLIMAVSAGR---------------------------EYVEATFSGGQNYLVYAIIMAI Sen3 IYLIMAVSAGR---------------------------EYVEATFSGGQNYLVYAIIMAI Sau1 LYFIACLFAGV---------------------------SYVHESISNGQNFIVFSLIQGV Spy2 FYLVATVASVLRN-------------------------ASVTEELAAGQNPFIFAIKSGL Cgl1 MYIILAILFLVRAGEEEAFTAFP---------------NG----ATNVGNYIMQSFTQGL Sco1 IYLVMSLLFLAKVGQDAAFKAFA---------------GSGGDPAADVGNYLMQSVMQGL Efa2 LYIITVLFAGEP----------------------------FASELSGDQNYIMFAFLQAI Lmo2 IYIFTSFFVDEP----------------------------VMKELAGTQSNVLFAILQSF Lin1 LFVVGAVILMVKKTPG----------------------AEKLIAEAGNQSFIVYSIVQSF Lmo1 LFVVGAVILMVKKTPG----------------------AEELIAEAGNQSFIVYSIVQSF Bha1 LFLVGAIILALKDTQG----------------------AQELIAQSGEQSFFIYAIIQSF Tte1 AFIITIIMLIASFFAE----------------------REVVVKQAGDLNFVMWSIIQGF Mpu1 LFIILILVIVFAGPAAGVTVVKNNTFQSIPNANPVINIDFKQWNVFSQAHYGVNIVFGSL Mpn1 LFVVLFIVILASYKGDKPLLINWDKFGAINGLEIWN-------TTFGGANFTLNIIGGAL Mpe1 LFLVLAVVLEVAAPTG-------SKFSDIVGSNTWWP------NGTIGSFWVVKIFMGAL . . Eco1 SFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFA-PNAVVWGFMWG Sfl1 SFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFA-PNAVVWGFMWG Sen1 SFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFA-PNAVVWGFMWG Sty1 SFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFA-PNAVVWGFMWG Vvu1 KFAVAIQVIVAGVRMFVAELSEAFKGISERVIPNAVLAIDCAAIYAFS-PNAMVFGFMWG Vch1 KFAVAIQVIVAGVRMFVAELSEAFKGISERVIPNAVLAIDCAAIYAFS-PNAMVFGFMWG Pmu1 KFAVAIQIIVTGVRMFVAELSEAFKGISERVIPNSVLAIDCAAIYAFS-PNAMVFGFMWG Sen2 QFSMYMVILLQGVRMMVGEINGSFKGWQDRFIPNAIPAVDVAALLPFS-PNAATLGFVFC Sty2 QFSMYMVILLQGVRMMVGEINGSFKGWQDRFIPNAIPAVDVAALLPFS-PNAATLGFVFC Eco2 QFSMYMVILLQGVRMMVGEINGSFKGWQDRFIPNAIPAVDVAALLPFS-PNAATLGFVFC Spy1 TFSVYLFILMQGVRMFVSELTNAFQGISSKLLPGSFPAVDVAASYGFGSSNAVLSGFAFG Sag1 TFSVYLFILMQGVRMFVTELTNAFQGISNKLLPGSFPAVDVAASYGFGSSNAVLSGFAFG Spn1 TFSVYLFVLMQGVRMFVSELTNAFQGISNKLLPGSFPAVDVAASYGFGSPNAVLSGFTFG Smu1 TFSVYLFVLMQGVRMFVGELTNAFQGISNKLLPGSFPAVDVAASYGFGSPSAVLFGFATG Lme1 GFAVNLAILQLGVRTFVGELTESFTGISDTILPNSVPGIDVAATFAFGEQNAVTIGFLFG Efac2 NFAVYLAILQLGVRTFVDELTQSFQGISNTILPGAVPGIDVAATFGFGSPNAVTIGFLFG Cpe1 TFAAGMIILLTGVRMILGEIIPSFKGIADKLAKGSIPALDIPMIFPYG-PNALLIGFIIA Oih1 LFGAGLTILLLGVRMMLAEIIPAFQGISQKWIPNAVPALDAPILFPYA-PNAVLIGFIVS Mpe2 TFAAGVEIVLLGVRMIVGELVPSFKGISDKLIKNAKAGIDCPVVFPYA-PNAVLIGFVCS Mpu2 VFAAGVEILLIGVRMFIAEVVPSFKGISQKLVPSAKAALDCPTIFPYA-PNAVLIGFISS Sag2 QFAAGVFVILAGVRLILGEIVPAFKGISEKLVPNSKPALDCPIVYPYA-PNAVLIGFISS Spn2 QFAAGVFVILAGVRLILGEIVPAFKGISERLVPNSKPALDCPIVYTYA-PNAVLIGFISS Lpl2 TFAGGVYVILAGVRLILNEIIPAFKGISENLVPNSVPALDCPIIFPYA-PNATIVGFFAS Efa1 TFTAGFVIVLQGVRMVLAEIVPAFQGIAKKLVPDSKPALDVPIVFPYA-PNAVLIGFFVS Efac1 TFTAGFVVVLQGVRMVLGEIVPAFQGIAKKLVPNSKPALDVPIIFPYA-PNAVLIGFFVS Lpl1 TFAAGFVVVLQGVRMILAEIVPAFQGIATKLVPNSKPALDVPIIFPYA-PNAVLLGFFVS Vvu2 TFAGGVYVILQGVRMVIAEIVPAFKGISDKLVPNAKPALDCPVVFPYA-PNAVLMGFLSS Vpa1 TFAGGVYVILQGVRMVIAEIVPAFKGISDKLVPNAKPALDCPVVFPYA-PNAVLVGFLSS Eco3 TFAAGVYIILQGVRMVIAEIVPAFKGISDKLVPNARPALDCPVVFPYA-PNAVLVGFLSS Ype1 TFAAGVYIILQGVRMVIAEIVPAFKGISDKLVPNAKPALDCPVVFPYA-PNAVLVGFLSS Sty3 TFAAGVFIILQGVRLILAEIVPAFTGFSEKLVPNARPALDCPVVYPYA-PNAVLIGFLFS Sen3 TFAAGVFIILQGVRLILAEIVPAFTGFSEKLVPNARPALDCPVVYPYA-PNAVLIGFLFS Sau1 TFAAGVFIILTGVRLILAEIVPAFKGISEKLVPNSKPALDCPIVFPYA-QNAVLIGFFVS Spy2 TFAVGVAIVYAGVRMILADLIPAFQGIANKLIPNAIPAVDCAVFFPYA-PTAVIIGFASS Cgl1 QFGVAVAVILFGVRTILGELVPAFQGIAAKVVPGAIPALDAPIVFPYA-QNAVLIGFLSS Sco1 QFGIGVAVILFGVRTILGELVPAFQGIAGRVVPGAKPALDAPIVFPYA-QNAVLIGFIFS Efa2 QFVVGVYVLLAGVRLLLGEIVPAFRGIAMKLVPDAIPALDCPVFFPYS-PNAVILGFITT Lmo2 TFVVGILILLQGVRMFLGELVPAFKGISEKIVPGAIPALDVPVFYSFA-PTATTIGFLCA Lin1 TFAAGIAIVLVGVRMFIGEIVPAFNGIATKLVPGAKPALDAPIVYPYA-PNSVIIGFVGA Lmo1 TFAAGIAIVLVGVRMFIGEIVPAFNGIATKLVPGAKPALDAPIVYPYA-PNSVIIGFVGA Bha1 MFAGGIAVVLLGVKMFIGEVVPAFNGIATKLVPGARPALDAPVVFPMA-PNAVILGFLGA Tte1 KFAAGITILLYGVRLFLAEIIPAFRGISQKLIPGARPALDVPVVFPYA-PTAVLIGFISS Mpu1 KIVAGLVALMTGVRMFVTELQQAFQGVSEKIIPNSVVAVDVAATYGFS-VNSVTYGFLAG Mpn1 KMVASLIAIMTGVRMFITELQQAFQGISEKVVPGAVVAVDIAAVYGFS-INSVTFGFLSG Mpe1 FLVAAILAIITGVRMFVTELQQSFQGISEKIIPGSVVAVDIAAVYGFS-PNAVTYGFISG : . : **: .: :: :* * .: .:* . . .: ** Eco1 TIGQLIAVGILVACGS-----------SILIIPGFIPMFFSNATIGVFANHFGGWRAALK Sfl1 TIGQLIAVGILVACGS-----------SILIIPGFIPMFFSNATIGVFANHFGGWRAALK Sen1 TIGQLIAVGILVACGS-----------SILIIPGFIPMFFSNATIGVFANHFGGWRAALK Sty1 TIGQLIAVGILVACGS-----------SILIIPGFIPMFFSNATIGVFANHFGGWRAALK Vvu1 AVGQFTAVLAMLAFDA-----------PIMIIPGFIPMFFSNATIGVFANHFGGWKAVMK Vch1 ALGQFAAVLAMLAFNA-----------PIMIIPGFIPMFFSNATIGVFANHFGGWKAVMK Pmu1 AIGQFVAVGLLLGFSS-----------PILIIPGFIPMFFSNATIGVFANQFGGWKSVMK Sen2 TFGTIFSIGILLLIHS-----------PIMVLPGFVPLFFSGGPIGVLANRMGGYRSVII Sty2 TFGTIFSMGILLLIHS-----------PIMVLPGFVPLFFSGGPIGVLANRMGGYRSVII Eco2 TFGTIFSMGILLLVHS-----------PIMVLPGFVPLFFSGGPIGVLANRMGGYRSVII Spy1 LIGQLITIALLVIFKN-----------PILIITGFVPVFFDNAAIAVYADKRGGWKAAVA Sag1 LIGQLITIALLVVFKN-----------PILIITGFVPVFFDNAAIAVYADKRGGWKAAVA Spn1 LIGQLITIVLLIVFKN-----------PILIITGFVPVFFDNAAIAVYADKRGGWKAAVI Smu1 LIGQLITIVLLIVFKN-----------PVLIITGFVPVFFDNAAIAVYADKRGGWKAAVV Lme1 ALGQFLAIGALMIFHS-----------PTIIIAGFIPLFFDNAVFGVIANNRAGAKAAMI Efac2 ALGQFLMIGLLILLKS-----------PTIVIAGFIPLFFDNAVIAVYANNRGGVKAACL Cpe1 LITSIGTLFLLGASGVLT----------FALIPLVVACYFDVAPGAIFANARGGWPAAII Oih1 MVTSVATIFITGSLGIFS----------FVIVPLTITCFFEIGTAAIIGNGTGGLKGAIA Mpe2 VIGAIVGLGLSVAISSSN-------NIIAIILPGITAQFFLGATTGVFGNVKGGLIGCIV Mpu2 FVGALLAMTITIGITSALPIMKNDSIGWAIILPSIVPHFFIGATSGVFANKNGGIWVAVL Sag2 FVGGLVSMIVMIVTG------------TTVILPGVVPHFFCGATAGVIGNASGGVRGATI Spn2 FVGGLVSMVIMIASG------------TVVILPGVVPHFFCGATAGVIGNASGGVRGATI Lpl2 FIGGVVSMFIMIGLH------------TVIVIPGVVAHFMCGATSGVIGNAVGGRRGAII Efa1 FFVGTLSMFAMIGLQ------------TTVIIPGVVGHFFCGAASGVFGNSTGGRRGAVL Efac1 FIVGTISMLAMVGLN------------TTVIIPGVVGHFFCGAAAGVFGNSTGGSRGAIL Lpl1 FIVGTLSMFIMIALG------------TTVIIPGVVGHFFCGAAAAIYGNSTGGRRGAII Vvu2 FAAGLLGMFLLYVMG------------LTVIIPGVVPHFFVGAAAGVFGNATGGRRGAIL Vpa1 FAAGLVGMFLLYVMG------------LTVIIPGVVPHFFVGAAAGVFGNATGGRRGAIL Eco3 FAAGLIGMFTLYLLN------------MIVIIPGVVPHFFVGAAAGVFGNATGGRRGAIL Ype1 FAAGLIGMFALYLLN------------MTVIIPGVVPHFFVGAAAGVFGNATGGRRGAIL Sty3 FLGGLVGLFLLGQMK------------LVLILPGVVPHFFTGATAGVFGNATGGRRGAMI Sen3 FLGGLVGLFLLGQMK------------LVLILPGVVPHFFTGATAGVFGNATGGRRGAMI Sau1 FITGVIGMFILFLFG------------GVVILPGVVAHFFLGATAAVFGNARGGIKGAVA Spy2 FVGGLLGMLILGVAG------------GVLIIPGMVPHFFCGATAGIFGNSTGGRRGAMI Cgl1 FVGGLVGLTVLASWLNPA-------FGVALILPGLVPHFFTGGAAGVYGNATGGRRGAVF Sco1 FLGGLTGLAALIWVFNPA-------FGLALVLPGLVPHFFTGGAAGVYGNATGGRRGAAV Efa2 TIGTIIAMFTLPMFG------------LAMILPGMLTNFFAGGTAGIFGNAVGGRRGAII Lmo2 VVGGLGATLVSTMLP-------------VVVLPSVIGLFFMGGAAGVFGNAMGGRRGAII Lin1 FIGAIIWLVVLGNTVG------------YVFVPTMIVLFFHGAVAGVFGNSTGGVRGALI Lmo1 FIGAIIWLVVLGNTVG------------YVFVPTMIVLFFHGAVAGVFGNSTGGVRGALI Bha1 FVGALIWLVVIGNTVA------------YIFVPTMIVLFFHSATAGVFGNATGGVRGAVL Tte1 TLVFLIFMVIFGLTGF------------ATIVPSMIMLFFPAAGAAVFGNAVGGWKGAVL Mpu1 TIAQFIGVGLVIGLSQIPG------LPIFIPIPLFITLFFNSGSLGVFANASGGYKAAII Mpn1 VIGQFLAVAIMAGISYIPGN-----QFSFVAIPLFITLFFNSGAFGVYANAEGGWKAALL Mpe1 TIAQYIGVGIVIGLTAAGLP-----TVVVFLYSLLYSLTLELLGLMQMLMVVEKHQLLFL . : Eco1 ICLVMGMIEIFGCVWAVKLTG--------------------------------------- Sfl1 ICLVMGMIEIFGCVWVVKLTG--------------------------------------- Sen1 ICLVMGMIEIFGCVWAVKLTG--------------------------------------- Sty1 ICLVMGMIEIFGCVWAVKLTG--------------------------------------- Vvu1 ICFVMGIIEVVGSAWAIHLFNQQGTE---------------------------------- Vch1 ICFVMGIIEVLGSAWAIHLFTQQGTE---------------------------------- Pmu1 ICFIMGIIEVLGSAWVIHLLATQGTT---------------------------------- Sen2 CTFLLGIIQTFGTVWAIPLTG-LAKE---------------------------------- Sty2 CTFLLGIIQTFGTVWAIPLTG-LAKE---------------------------------- Eco2 CTFLLGIIQTFGTVWAIPLTG-LAEN---------------------------------- Spy1 LSFISGIIQVALGAVAVGLLG--LTG---------------------------------- Sag1 LSFISGIIQVALGAVAVGLLG--LAG---------------------------------- Spn1 LSFISGVLQVALGALCVALLD--LAS---------------------------------- Smu1 LSFLSGVLQVALGAVAVALLG--LAG---------------------------------- Lme1 LPFFSGIIQVVGAALISTWIG--MSK---------------------------------- Efac2 FPFLSGLIQVGGSALFATWIG--LSQ---------------------------------- Cpe1 TSALGGIILMVLAAIS-------------------------------------------- Oih1 GSAVAGVVMILLVGLS-------------------------------------------- Mpe2 ASFLNGIIITFVPIMFSAAGWTP------------------------------------- Mpu2 GPFLSGLLMSFVPFIFFGLEYMPTVLVSNASGQK-------------------------- Sag2 GAFVQGILISFLPIFLMPVLGGLGF----------------------------------- Spn2 GAFLQGILISFLPVFLMPVLGGLGF----------------------------------- Lpl2 GAFSQGILISFLPLALLPVLGKIGL----------------------------------- Efa1 GSAFNSLLISWLPLFILPVLGDLKI----------------------------------- Efac1 GAAFNGLLISWLPLFILPVLGDLQL----------------------------------- Lpl1 GATVNSLLISWLPLFILPVLGSLKL----------------------------------- Vvu2 GAFAQGLLITFLPVFLMPVLGDLGF----------------------------------- Vpa1 GAFAQGLLITFLPVFLMPVLGDLGF----------------------------------- Eco3 GAFAQGLLITFLPVFLLPVLGDIGF----------------------------------- Ype1 GAFAQGLLITFLPVFLLPVLGDIGF----------------------------------- Sty3 GAFANGLLITFLPVLLLPVLGAIGF----------------------------------- Sen3 GAFANGLLITFLPVLLLPVLGAIGF----------------------------------- Sau1 GAALNGILITFLPLLFLPFLGELGG----------------------------------- Spy2 GAFANGLLLAFLPAMLLPVLGKLGF----------------------------------- Cgl1 GAFANGLLITFLPAFLLGVLGSFGS----------------------------------- Sco1 GSFLNGLLITFLPAILLKALGSFGE----------------------------------- Efa2 GGIAHGFFITLLPALLVTIFNSMGF----------------------------------- Lmo2 AGLLLGFIFQMIVAIAYPILGLDGYG---------------------------------- Lin1 GGFLTATVVAWGQYIMVTFFINTTVP---------------------------------- Lmo1 GGFLTATVVAWGQYIMVTFFINTTVP---------------------------------- Bha1 GGFMTSTVVAWGQFIMVKFLISSTNP---------------------------------- Tte1 GGAINGLFLAFGQALTWPMLG-NTAP---------------------------------- Mpu1 VPAIVGFLEIIVIAFGTAALSNAFAATN-------------------------------- Mpn1 LPGIIGFLEIIVISFALRTVSNAYQASALLDAKQSFDLKALMGNSLDNNNGSALKTAVEK Mpe1 QSLVSLKL---------------------------------------------------- . Eco1 ----------------------------------------------MSAWMGMADWSILA Sfl1 ----------------------------------------------MSAWMGMADWSILA Sen1 ----------------------------------------------MSAWMGMADWSILA Sty1 ----------------------------------------------MSAWMGMADWSILA Vvu1 ----------------------------------------------FNGWMGMADWALVF Vch1 ----------------------------------------------FSGWMGMADWALVF Pmu1 ----------------------------------------------FNGWMGMADWALFF Sen2 ----------------------------------------------GVGWTGIFDWATLW Sty2 ----------------------------------------------GVGWTGIFDWATLW Eco2 ----------------------------------------------GVGWTGIFDWATVW Spy1 ----------------------------------------------G--YHGNIDLVLPW Sag1 ----------------------------------------------G--YHGNIDFEFPW Spn1 ----------------------------------------------YGGYHGNIDFEFPW Smu1 ----------------------------------------------FGGYHGNIDFEIPW Lme1 ----------------------------------------------FGGYLGMFDWDTVW Efac2 ----------------------------------------------YGGYLGMFDWATAW Cpe1 -----------------------------------------------LNLVSGTVGNFIQ Oih1 -----------------------------------------------VPILNGTIADWIV Mpe2 --------------------------------------SNATLGWGDTDYFLGAIPGLLS Mpu2 --------------------------------------VPSSITWGDSDYLLGVPFSFIG Sag2 ----------------------------------------------KGSTFSDADFGLTG Spn2 ----------------------------------------------QGSTFSDADFGLSG Lpl2 ----------------------------------------------GGATFSDADFGVIG Efa1 ----------------------------------------------ASSTFADTDYLVPG Efac1 ----------------------------------------------ASSTFADTDYLIPG Lpl1 ----------------------------------------------AASTFADTDYLVPG Vvu2 ----------------------------------------------ANTTFSDADFGAVG Vpa1 ----------------------------------------------ANTTFSDADFGAVG Eco3 ----------------------------------------------ANTTFSDADFGALG Ype1 ----------------------------------------------ANTTFSDADFGALG Sty3 ----------------------------------------------ANTTFSDADFGVIG Sen3 ----------------------------------------------ANTTFSDADFGVIG Sau1 ----------------------------------------------AATTFSDTDFLTVG Spy2 ----------------------------------------------SNTTFGDVDFGVLG Cgl1 ----------------------------------------------ENTTFGDADFGWFG Sco1 ----------------------------------------------ANTTFGDADFGWFG Efa2 ----------------------------------------------NNATATDVDTVAAA Lmo2 ---------------------------------------------IQGLWFASTDAIIVI Lin1 ---------------------------------------------DTAMWAADSDMFILG Lmo1 ---------------------------------------------DTAMWAADSDMFILG Bha1 ---------------------------------------------DTAMWAADSDMFILG Tte1 ---------------------------------------------ELAVLADPDWYVIIW Mpu1 ---------------------------------------TQGINPVSIGYNGMADWNLFY Mpn1 VVNATGVNRITEAQSFVKSDSFNSLKAVNSTLAQAIEWISKSASPVDNGFIGMADWNLYF Mpe1 ------------------------------------------------------------ Eco1 PPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA------------ Sfl1 PPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA------------ Sen1 PPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA------------ Sty1 PPMMQGFFSLGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA------------ Vvu1 PPIMQGLSAS-KMFFFVLVGLSLVYMFFASRKLRSE-----------EDAQGTVVVSEEP Vch1 PPIMQGLSAS-KLFFFVLVALALVYMFFASKQLRAE-----------EDAQGSITVSDEP Pmu1 PPILQGIVSI-PGFFFVLLTLAIVYMVFASKQLRSEEAAAAALGKTLEQMDGYDKTEHSP Sen2 PAICELLKFIASTFHLGPYSI--------------------------------------- Sty2 PAICELLKFIASTFHLGPYSI--------------------------------------- Eco2 PAICEVLKFIAATFHLGPYAG--------------------------------------- Spy1 LPFGYLFKFLGIAGYVLVCIFLLAIPQLQFAKAKDKEAYYRGEAQ--------------- Sag1 LAFGYIFKYLGIAGYVIVCLFFLAIPQLQFMKSKDKEAYYRGDAPAE------------- Spn1 LGFGYIFKYLGIVGYVLVCLFLLVIPQLQFAKAKDKEKYYNGEVQEEA------------ Smu1 VPFAYLFKYAGVIGYALVAVFLLAIPQIQFAKAKDKEAYYRGDAQAE------------- Lme1 PVFTVILKYLGYFGVVLVAAILLLIPQLEYRKDPKNYFLMVEDYDAYKENKGIE------ Efac2 PLFTIIMKVLGYVGVAVVVIGLLIIPQLQYRKNPEGYFMIVNDYEQYAKKFQEN------ Cpe1 TYGGNEFSIWVIIGDLVGKLFSI------------------------------------- Oih1 IFGGNDFSLWAFMTDWIAKLF--------------------------------------- Mpe2 LPSSIGVKYGLLLAIPIAAYVGLVIDGLLKRFVFDKRKAAKIQQPEIGINE--------- Mpu2 KIVGRNTFIWLLPTLAAFLWLIYPVINLSKKLLKIKDKNAKVGDENFDQKQEKNLEKTKV Sag2 IILGALNHVGGAIAIVIGIVVILIGLFGISFVGKSTHKEG-------------------- Spn2 IILGMLNQFGSQAGIVIGLVLILAVMFGVSFIKKPSATEE-------------------- Lpl2 SLIGWSGVNGGVVMIIAAIVISLILFIVASIIASKHSADKTGQNKANA------------ Efa1 LVLGKLGEYGQIALTVGIIAFFLLVVLSSFLFAGKRTNIVSKEQN--------------- Efac1 LFLGKLGEAGPSLLVGGIIAFVVVVLLASAVLTMREKKVAEEN----------------- Lpl1 ILLGKLGSYGSVAVITGIILFTIIVILCSIFLTRRAKRMTDGTK---------------- Vvu2 ILLGLIVR---------------------------------------------------- Vpa1 ILLGLIVR---------------------------------------------------- Eco3 ILLGIIVR---------------------------------------------------- Ype1 ILLGIIVR---------------------------------------------------- Sty3 ILLGNLARYLSPMAITGLVVALFALLVAYNVLAKNKKATAEVQENSGAKE---------- Sen3 ILLGNLARYLSPMAITGLVVALFALLVAYNVLAKSKKATAEVQENSGAKE---------- Sau1 IVFGNAVKYMGLFGAILFIIIVGATAILLKGRQKPQQ----------------------- Spy2 ILLGRLGTSIGQIGIYLVVAVLAIVLVLPNFLSKSQEAINNVSEEI-------------- Cgl1 IVVGSAAKVEGAGGLILLLIIAAVLLGGAMVFQKRVVNGHWDPAP--NRERVEKAEADAT Sco1 AVLGSIGKLDGTAGLIGMLIFGLLILAGAWIMQTKVVDRGWIPGGGITAAPAEAAAVVPA Efa2 LLYAWILSPVLKAF---------------------------------------------- Lmo2 VIIRLIGALFGIAL---------------------------------------------- Lin1 PIVSMLAKLFF------------------------------------------------- Lmo1 PIVSMLAKLFF------------------------------------------------- Bha1 PIVRFLAQLLL------------------------------------------------- Tte1 LIIGVGKLIKLVIG---------------------------------------------- Mpu1 GLLYILGGYNVYAGYIFAISFIFGLLFFGQIVDSGRQSQKTFFQKLLKLNPELIQQNS-- Mpn1 GLLVWIGAYNVIGGWILVILATVGLILLAQIIDNGKQTKVTKLQQLLKINPQLDLNN--- Mpe1 ------------------------------------------------------------ Eco1 ------------------------------------------------------------ Sfl1 ------------------------------------------------------------ Sen1 ------------------------------------------------------------ Sty1 ------------------------------------------------------------ Vvu1 DVIEAVEQAIKASDGVRPVSILAVCGNGQGSSMMMKMKIGKYLEKKGIPHVMDSCAVSDY Vch1 EVIEAVEQALQAAQGTRPVSILAVCGNGQGSSMMMKMKIGKYLEQKGIPHVMDSCAVSDY Pmu1 ITPDDSVQHDVLKTAVNPIRILAVCGSGQGSSMMMKMKIKSYLDKHNIPNTLDSCAVTDY Sen2 ------------------------------------------------------------ Sty2 ------------------------------------------------------------ Eco2 ------------------------------------------------------------ Spy1 ------------------------------------------------------------ Sag1 ------------------------------------------------------------ Spn1 ------------------------------------------------------------ Smu1 ------------------------------------------------------------ Lme1 ------------------------------------------------------------ Efac2 ------------------------------------------------------------ Cpe1 ------------------------------------------------------------ Oih1 ------------------------------------------------------------ Mpe2 ------------------------------------------------------------ Mpu2 TNEPKDLFLKSNVGQRNKLMAVCGQGLGSSLLIEINLKTVLRDMQIQIIEVDHTNVNSFN Sag2 ------------------------------------------------------------ Spn2 ------------------------------------------------------------ Lpl2 ------------------------------------------------------------ Efa1 ------------------------------------------------------------ Efac1 ------------------------------------------------------------ Lpl1 ------------------------------------------------------------ Vvu2 ------------------------------------------------------------ Vpa1 ------------------------------------------------------------ Eco3 ------------------------------------------------------------ Ype1 ------------------------------------------------------------ Sty3 ------------------------------------------------------------ Sen3 ------------------------------------------------------------ Sau1 ------------------------------------------------------------ Spy2 ------------------------------------------------------------ Cgl1 PTAGARTYPKIAPPAGAPTPPARS------------------------------------ Sco1 QAAGTATYAKIAPPRGAPAPPPAP------------------------------------ Efa2 ------------------------------------------------------------ Lmo2 ------------------------------------------------------------ Lin1 ------------------------------------------------------------ Lmo1 ------------------------------------------------------------ Bha1 ------------------------------------------------------------ Tte1 ------------------------------------------------------------ Mpu1 ------------------------------------------------------------ Mpn1 ------------------------------------------------------------ Mpe1 ------------------------------------------------------------ Eco1 -------------------------------------------------------- Sfl1 -------------------------------------------------------- Sen1 -------------------------------------------------------- Sty1 -------------------------------------------------------- Vvu1 KSKLASTDIIVSSKHLSAEMEPGEGKFVLGVQNMLNPNSFGDELLDIINKNFVSAK Vch1 KSKLATTDIIVSSKHLSAEMEPGEGKFVLGVQNMLNPNSFGNELLDIIHNHFVKIR Pmu1 KGKLNEIDIIVASRHLADEIEVGEDKFVLGVQNMLNPNSFGPELIALIKKYQQTT- Sen2 -------------------------------------------------------- Sty2 -------------------------------------------------------- Eco2 -------------------------------------------------------- Spy1 -------------------------------------------------------- Sag1 -------------------------------------------------------- Spn1 -------------------------------------------------------- Smu1 -------------------------------------------------------- Lme1 -------------------------------------------------------- Efac2 -------------------------------------------------------- Cpe1 -------------------------------------------------------- Oih1 -------------------------------------------------------- Mpe2 -------------------------------------------------------- Mpu2 KDDPKILAVVCGVDLANSIDFDNKIILNNLLDRNELKNKLKEFLQKNNFLNN---- Sag2 -------------------------------------------------------- Spn2 -------------------------------------------------------- Lpl2 -------------------------------------------------------- Efa1 -------------------------------------------------------- Efac1 -------------------------------------------------------- Lpl1 -------------------------------------------------------- Vvu2 -------------------------------------------------------- Vpa1 -------------------------------------------------------- Eco3 -------------------------------------------------------- Ype1 -------------------------------------------------------- Sty3 -------------------------------------------------------- Sen3 -------------------------------------------------------- Sau1 -------------------------------------------------------- Spy2 -------------------------------------------------------- Cgl1 -------------------------------------------------------- Sco1 -------------------------------------------------------- Efa2 -------------------------------------------------------- Lmo2 -------------------------------------------------------- Lin1 -------------------------------------------------------- Lmo1 -------------------------------------------------------- Bha1 -------------------------------------------------------- Tte1 -------------------------------------------------------- Mpu1 -------------------------------------------------------- Mpn1 -------------------------------------------------------- Mpe1 --------------------------------------------------------