CLUSTAL X (1.81) multiple sequence alignment Sen1 ---MKLRDSLAENNSIRLQAEANTWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPY Sty1 ---MKLRDSLAENNSIRLQAEANTWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPY Eco1 ---MKLRDSLAENKSIRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPY Sfl1 ---MKLHDSLAENKSIRLQAEAETWQDAVKIGVDLLVAADVVEPRYYQAILDAVEQHGPY Vvu1 ---MGLKQSLIENNSIKLQAQASNWRDAIKIGTDMLIASGAIEPCYHDAIISSVEELGPY Vch1 ---MGLKQSLIENNSIQLQAKANNWREAIKIGTDMLIASGAITPAYHEAIIASVEQLGPY Pmu1 ---MNLKQSLIENNSIKLHQTAKNWEEAIKLGTDMLIASGAVEPRYHDTIIKCVKELGPY Sag1 ---MNLKQAFIENDSIRLKLSASDWKEAIKLSIDPLIESGAVDAEYYDAIIESTEEFGPY Smu1 ---MNLAQAFKENHSIRLGLTAKDWKEAVKLSVTPLIESGAVKPEYYNAIIESTESYGPY Spn1 ---MNLKQALIDNDSIRLGLEANNWKEAVKVAVDPLIESGAILPEYYDAIIESTEEYGPY Spy1 ---MNLKQAFIDNNSIRLGLSADTWQEAVQLAVQPLIDSKAVTSAYYDAIIASTEKYGPY Mpe1 ------------------------------------MIKKVIDENYYLSILESLKNYGPY Mpu1 MSKINLLENLKKNDSITLNVEVSSWQEAIYEGCRVLIEKKLITKDYYNAIIESTLKNGPY Mpn1 MTKLDFKAVLKQHHTVRLHQTAQDWKQAIQLCIHPLIAAKLVQPAYFDDILKSVAQYGPY Vvu2 -----MLSELITSDVIRVHPQATDWQDAVQKSCQALIDNGAVEARYVDAIFRSHQELGPY Vpa1 -----MLRELITSDVIRIHSDATDWKDAISKSCEALIENGAIEPSYVEAIYRSHEELGPY Ype1 -----MLKTLLTSDVIQVVSQAKDWRDAIAISCQPLIDNGAVEARYVEAIYRSHEAIGPY Sty3 -----MLGTWLSDATITLQESVETWPQALEICGKPLLDAGVIAPEYLTAIVQQHQKLGPY Sen3 -----MLGTWLSDATITLRESVETWPQALEICGKPLLDAGVIAPEYITAIVQQHQKLGPY Lin1 -------MSFLDKELVNLHGSAKNADEAIMQAGELLVNAGYVSEQYVEKMVESYHENGAY Lmo1 -------MSFLDKELVNLHGSAKNADEAIVQAGELLVNAGYVSEQYVEKMVESYHENGAY Bha1 -------MKFLEEPLVAFDLEASSPEEAIRKTGKLLVGNQLVEDEYVEAMVRSYQKNGPY Oih1 -------MKQLRKNHISILTEAKDWRAAIELSGQLLVHSGAVTEQYVESMIASVEDNGPY Tte1 ------------------NVEAKDWEEAVRIGGELLVKNGFAEPQYVEAMINTVKEMGPY Cgl1 ---MFVLKDLLKAERIELDRTVTDWREGIRAAGVLLEKTNSIDSAYTDAMIASVEEKGPY Sco1 ---MSALTDLLSVDGIRLDVEVEDWRSAVRASGQVLVDEGISTAEYTEAMIRNVEENGPY Lmo2 -------MLPITLEQIELDVEVESPVDAIRAAGNLLVKTESASSDYVDAMVASYEKLGPY Cpe1 --MVNFIRDLLNENNIILKAKAFNKEEAVRLAAEPLLKDGSITDEYVKDILEKINDLGPY Sau1 -----MSLDILSTTRIIVKEQVNDWTEAITIASQPLLQEQIIEQGYVQAMIDSVNELGPY Spy5 -----------TADFIRQADAVSDWQEAIRLAAQPLLEHQMIETSYIDGMIDSVNELGAY Sag2 ------------------------------------------------------------ Spn2 ---------ITKETYQVSSQK-LGWKEAIRLAAKPLLDQDKITENYPEAMIQKVEEFGPF Efc1 ----MLSELLTEEMIQLSDQP-KNWQEAITFAAQPLLSENKIEESYIKAMIERVEQYGAF Efa1 ---------LTTETVQVLPEV-ADWRAGITEAAKPLLKNGSITEKYIDAMIQKVESFGPF Lpl2 -----------------------DWQQAIALATLPLLSSGNVEQSYIDAMIRNVYSNGPY Lpl1 ----MLLDLLNKQTVQVSEGTGLDWKQAIELAAEPLINNKTIEDGYIKEMLNVVESEGPY Lme1 --MTMLKYFHDNDLVRIYDETPQDWREALRIASENLKEKEIITDAYINEIIKNVEVNGAY Efc2 ----MLTYFWEQELIHYPDKEPVSWQEAIQESCLILLQKHIIDQSYVDEIIQCVETFGPY Mpe2 ---------MTSNDLIAFHKGNISWQESIRLAVSLLVKNNIAESGLADEIIKSTLKYGPY Sen1 FVIAPGLVMPHGRPE-EGVKKTGFSLVTLKKPLEFNHEDN----DPVDILITMAAVDANT Sty1 FVIAPGLAMPHGRPE-EGVKKTGFSLVTLKKPLEFNHEDN----DPVDILITMAAVDANT Eco1 FVIAPGLAMPHGRPE-EGVKKTGFSLVTLKKPLEFNHDDN----DPVDILITMAAVDANT Sfl1 FVLAPGLAMPHGRPE-EGVKKTGFALVTLKKPLEFNHEDN----DPVDILITMAAVDANT Vvu1 ICIAPNLALPHARPE-NGVNRTAFALVTLETPIYFEGED-----EPVDVLITLAGSSSDE Vch1 ICIAPNLALPHARPE-NGVLRTAFALVTLQEPIYFEGED-----EPVDVLITLAGSSSDE Pmu1 IIIAPHLAMPHARPE-DGVNRTAFALVTLDTPIYFDGED-----EPVDVLLTLAGSDANQ Sag1 YILMPGMAMPHARPE-AGVKRDAFSLITLTEPVVFP--DG----KEVSVLLALAATSSAI Smu1 YILMPGMAMPHARPE-AGVQRDAFSLVTLTEPVTFT--DG----KEVQVLLALAATSSKI Spn1 YILMPGMAMPHARPE-AGVQSDAFSLITLQNPVVFS--DG----KEVSVLLALAATSSKI Spy1 YVLMPGMAMPHAEAG-LGVNRNAFALITLTKPVTFS--DG----KEVSVLLTLAATDPSI Mpe1 FIIADHVAMPHAQNE-VGVFDNGFSLITLEKEIYFEG-DN----RPIDILIGLASASSDI Mpu1 YIISDNLAMPHAQMN-RGVFDNCFSLVTLKKPIFFEG-DS----RPVRILITLAATSAEI Mpn1 FIIAENVAMPHAQNN-GTVQQNCFSLVTLKEPVYFDN-DP----RPVRLLIGLAATSAAI Vvu2 YVIGPGMAMPHARPE-DGVNRLALAITVIQQGVHFDSEGN----DPVKMLVTLAATDSNS Vpa1 YVVGPGMAMPHARPE-DGVNRLSLAITVIQNGVNFNSEEN----DPVKMLVTLAATDSNS Ype1 YVVGPGIAMPHARPE-DGVNRLSLALTVITEGVTFNAEGN----DPVKLLIVLAATDSNS Sty3 YVLAPGLAMPHARPE-EGAKGLGLSLLKLQHGVSFGADEF----DPVDIIIMLAAPDKHS Sen3 YVLAPGLAMPHARPE-EGAKGLGLSLLKLQRGVSFGADEF----DPVDIIIMLAAPDKHS Lin1 FVIAPQIAIPHARPT-DGVENSAVSLVVLKDGVNFGHAAN----DPVRLVFGLAATSSEA Lmo1 FVIAPQIAIPHARPT-DGVENSAVSLVVLKDGVNFGHAAN----DPVRLVFGLAATSSEA Bha1 FVVAPNIALPHARPE-DGVKEAAVAFVRLKRPISFGHSSN----DPVRFVFALAAASSGE Oih1 IVIAPGIAIAHARPN-ESVKENALALAIFKEPVAFHSKEN----DPVDLVFSFSAKGDES Tte1 IVIAPGIAMPHARPE-AGARKIGMSLITLKNPVNFGNKEN----DPVKIVVSLCAIDHSS Cgl1 IVVAPGFAFAHARPS-RAVRETAMSWVRLASPVSFGHSKN----DPVNLIVALAAKDATA Sco1 IVIAPGFALAHTRPF-DAVLKTGMSWVRLASPVVFGHETN----DPVQLVVALAAVDSKA Lmo2 IVLAPHIAIPHARPE-HGVKKQCMSIVRLKKPIKFGHPAN----DDVSLVIAIGGVDTNF Cpe1 MAIMPGVVIAHSRPG-DYVFKECISMLTLENPVEFGHEDN----DPIEIIFVIGAKENTG Sau1 IVIAPEIAIAHARPN-NDVHQVGLSLLKLNQHVAFCD-----EDHYASLIFVLSAIDNHS Spy5 IVLAPKVAVPHAAPE-KGARQLGMSLLQLKEPVSFDLKQEGDPDKQVQLIFVLSAVDSSS Sag2 ----------------------------MEQPIYLLDDP----KQEIYLLLCIAAIDNET Spn2 INLGKGVAIPHARPD-EGVNEIGMSMLVLEEPIYLLDNP----EQEVRLLICIAAIDNES Efc1 IHIGDHIALPHARPE-DGVNEVGMSLLKLQQPVDLLDNP----AHPISLFICLAAIDNEA Efa1 IHICPDVALPHARPE-DGVNQLGMSLLKIQKSVDLLEDP----KHEIHLFICLAASDNET Lpl2 INIGDRIAFAHARPE-EGVNKLGMALLCLDEPIELLDN-----QHRIQLIFVLAASNDRS Lpl1 INIGPQIALAHSRPA-GNVHEIGLSILKTNHSISLVND-----EHPINLWFVLAAVDNNS Lme1 IVIVPGVVMPHALATGPGVLGTGIGFAKFSEMVSFEEGNP---EKQGKLFFTLAAKNEEQ Efc2 IIIAPEVAMPHSSEESAGVFGTAISFTKFKQAVTFAGDQE---AKTATLFFTLAAQNPAE Mpe2 YVIAEKVALAHTAVC-EYNKKPGMSLVIFENAIKFSENQK----HEVNLLFCMSAIDSDS : : . . : . Sen1 HQEVGIMQIVNLFEDEA-----NFDRLRACRTAQEVLDLIDRTNAAA----------- Sty1 HQEVGIMQIVNLFEDEA-----NFDRLRACRTAQEVLDLIDRTNAAA----------- Eco1 HQEVGIMQIVNLFEDEE-----NFDRLRACRTEQEVLDLIDRTNAAA----------- Sfl1 HQEVGIMQIVNLFEDEE-----NFDRLRACRTEQEVLDLIDRTNAAA----------- Vvu1 HMEG-LMEVTQVLDDEESDTGVDLDKLRRCRSLSDVFNVIDDALAMTA---------- Vch1 HMEG-LMEVTQVLDDENSATGVDLDKLRRCRDKQQVYAVIDQALSQQASAQQELAHIA Pmu1 HMQG-LMEITQVLDDPDSDTGINLDKIRRCQTAEDVYAVIDAVLN------------- Sag1 HTSVAIPQIIALFELEN-----SIQRLTECQEAKEVLAMVEESKNSPYLEGLDLES-- Smu1 HTSVAIPQIIALFELDH-----SIERLVNCKTPEEVLAMVEESKSSPYLEGLDLDS-- Spn1 HTSVAIPQIIALFELED-----SIARLQACQTKEDVLAMIEESKDSPYLEGLDLES-- Spy1 HTTVAIPQIVALFELDN-----AIERLVACQSPKEVLEMVEESKDSPYLEGMDLNA-- Mpe1 HVGVALPQIVSIFENEE-----NIEKIRKAKSKEEVINVIKSVDLKKYL--------- Mpu1 HTSEALPQIVAIFEDPA-----NIEKIMNAQNKEEVIDLISKIDFTKYIF-------- Mpn1 HTTEALPQIAALVEDTQ-----VVKDLLDCCDETSLFAVIDRVNLHKYLT-------- Vvu2 HVGAIAKLAELFMNEEH------VEQICQAQTPDDVLAVIKNY--------------- Vpa1 HVDAISKLAELFMNEEH------VEAICNAQSKEDVLAIIDKY--------------- Ype1 HIEAISQLAQLFDTASD------VQALLNAKTPQDILSVIARY--------------- Sty3 HIEMISALAELFSSDVD------MEKLHQAKNLEDIKTIIDRF--------------- Sen3 HIEMISALAELFSSDVD------MEKLHQAKNLEDIKTIIDRF--------------- Lin1 HLKVIQKIVSLLSNSDN------IEKMIHSEDYQAIGELVEG---------------- Lmo1 HLKVIQKIVSLLSNNDN------IEKMIHSEDYQAIGELVEG---------------- Bha1 HLQVLQKLMQLLGNREN------IARLANVSDYKGIDQLLGGDAS------------- Oih1 HLKMIEQLSMFLMEEEQ------VNALRNASTIEEAYQIISKGDEGNE---------- Tte1 HLKALSELVELLGDEEF------VEAVLNANDVDRVLKLLGKEKV------------- Cgl1 HTQAMAALAKALG--KY------RKDLDEAQSPEEIQAILEKAA-------------- Sco1 HTAALAALAKVLADGDN------VRALQQATSPEEVLRVL------------------ Lmo2 HIKMLQALSELLTDEDK------LKRLKTSTDKAEILCTINKEEK------------- Cpe1 HLDALQDLARVLINEDS------VNKIKNAQNKKEIMELFM----------------- Sau1 HLSVLQNLATVLGDNQT------VQQLLTATNAQDIKNILKEHD-------------- Spy5 HLKALQELSLILDDDEH------IEQLIEAKNTEEIMSLISHMIEKGDESHD------ Sag2 HLKALSHLTTILRDNNN------VKALLASRRYQDIEMIIKQED-------------- Spn2 HLKALSHLTTILRDKNH------VQTLISSKNYDDIKMIIKQED-------------- Efc1 HLRALANLTKLLSNKQN------LQDLLHASTKEEILAIIRKGDE------------- Efa1 HLRALSSLTKILSKKES------LHRLVAAETVPEILSIIQEGEK------------- Lpl2 HLKALAELASMLGDKNR------LKQLLDARKVSEVESVIAEGEKQL----------- Lpl1 HLAVIKELMELLTDESA------VTAMLNATSEVDILEVIAHEQELQK---------- Lme1 HLENIQNLMALLMTDGM------IEALSNIETLDDFNQVMNHFESIPAE--------- Efc2 HLENIQQLMDLLMTDGV------IADLLETNTPMDFKEVMEKYQL------------- Mpe2 HMGILQKFANTLSQKDI------VSKILNESDKTKIYEIFKGLI-------------- * . : .