Fig. S7. CLUSTAL X (1.81) multiple sequence alignment Lin -------------------------------------------------------MLYKL Chu ------------------------------------------------------------ Vpa ------------------------------------------------------------ Vch ------------------------------------------------------------ Vvu ------------------------------------------------------------ Bfu ------------------------------------------------------------ Bps ------------------------------------------------------------ Rso ------------------------------------------------------------ Mtu YIDDSVSEAISDWRRAHETRGGVVAIVETS----------------------PAKLHHAH Nfa ------------------------------------------------------------ Sav -MDHAAYESLQDWQTAHTAQGGSVEFTGRAGTRISLPAMEAPAAERSTGLGEASACRCRP Sco FMDHAAYETLQDWQKTHTAQGGSVDITGRR------------PGTRISEPAEEDGCRCRP Xax ------------------------------------------------------------ Xca ------------------------------------------------------------ Pfl ------------------------------------------------------------ Psy ------------------------------------------------------------ Ppu ------------------------------------------------------------ Pae ------------------------------------------------------------ Avi ---MALRHRCRRVPAGTIGRDELRCIRFHLSCVAGYSVSLKLWAPRIQLYLSWLTQADFH Nar ------------------------------------------------------------ Mfl ------------------------------------------------------------ Lpn1 ------------------------------------------------------------ Aci ------------------------------------------------------------ Neu ------------------------------------------------------------ Lpn2 ------------------------------------------------------------ Pir --------------------------------------------------------VIDA Dps ------------------------------------------------------------ Bsu ------------------------------------------------------------ Lin DKVPDNAHLIIDGSRSKYIDPDVLEIIEDFKIVARSRNIKLEIIDVTSSYEKIQNKPLDL Chu ------------------------------------------------------------ Vpa ------------------------------------------------------------ Vch ------------------------------------------------------------ Vvu ------------------------------------------------MYSDARIFREVR Bfu ---------------------------------------MRPRERSREFGAESMRLAYGA Bps ------------------------------------------------------------ Rso ------------------------------------------------------------ Mtu ARPPKRHFASDPIGLVP--------------------------------------WRSAR Nfa ------------------------------------------------------------ Sav WTPWRNHQCARPQPAPP-----------------------------------GEDPDESA Sco WTPWRNHQCERPPTAPPRGTAGRSATDGSPAGNLGTSTGPNTPGTRDATGARGATGGSSA Xax ------------------------------------------------------------ Xca ------------------------------------------------------------ Pfl ----------------------------------------MSDKDKQPLAASAQAAPVAE Psy ------------------------------------------------------------ Ppu --------------------------------------------MPVKDPSKVVPQVPAE Pae --------------------------------------------MPDRMRGVKSDSPEQE Avi RGHPSAPRPPVPKSSSRLVINGDDHRALPLSATQGGYAMNNVISKQGPSQGTTEARTESE Nar ------------------------------------------------------------ Mfl ---------------------------------------------------------MSP Lpn1 ------------------------------------------------------------ Aci ------------------------------------------------------------ Neu ----------------------------------------------MRTLTREMQAHLSP Lpn2 ----------------------------------------------MWTLTKEQQQAITP Pir SGSDYIDPDVLSLIRDFKQNVAPARNISVNLKGFRRKYQLSDSKQFADFTSRELQEKVTS Dps -------------------------------------------------MPMETQKRPTA Bsu ------------------------------------------------------------ Lin VLQQDYQKLFENNRIWVEEKLSKDPDYFKNLAL-GQTPQYLLISCSDSRLSVNEMTGTSA Chu -MKESYQKLLNNNKIWALGKIQDDADYFKRMKL-AQTPEYLWIGCSDSRVPETEVTGTLQ Vpa --MPEIKQLFENNSKWSEEIKSDRPEYFAKLAE-GQKPDFLWIGCSDSRVPAERLTGLYS Vch --MPEIKQLFENNSKWSESIKAETPEYFAKLAK-GQNPDFLWIGCADSRVPAERLTGLYS Vvu RNMPEIKQLFENNSKWSEEIKSHQPEYFSKLEE-GQNPGFLWIGCSDSRVPAERLTGLYS Bfu LSMNRPKRLLVANVAWAHETAVRNPAFFRDLVR-GQNPHVLWIGCSDSRVPAETITHCEP Bps --MNRPKSMLVANIAWARETSERSPDFFDALSR-GQNPRVLWIGCADSRVPAEAITQSAP Rso --MYRPKRMLVGNVAWAHEIAERDPRFFSRLAQ-GQKPQVLWIGCADSRVPAETITHSNP Mtu GKDRGSASVLDRIDEYHRNGAAVLHPHIAGLT-DSQDPYELFLTCADSRILPNVITASGP Nfa -----------------------MRAHLSELR-DRQDPTTFFLTCGDSRVVPNLITHSGP Sav ATGPSGHQLARGISAFQRNTAPLVRGELARLAREGQRPSQLFLTCADSRLVTSMITSSGP Sco PDGPTGHELARGISAFHRNTGPLMRRELARLAREGQQPSQLFLTCADSRVVTSMITSSGP Xax -----MESLLEGFRHFRKEVYPRQSARFQELAG-GQSPHTLFITCADSRVMPELIFSAQP Xca -----MESLLEGFRHFRKEVYPRQSARFHELAA-GQKPHTLFITCADSRVMPELIFSAQP Pfl SADAALKRIVDGFLHFHHEVFPQQEELFKKLAT-AQSPRAMFITCADSRIVPELITQSSP Psy -----MKHIVDGFVHFRKEVFPQQEELFKKLAT-AQSPRAMFITCADSRIVPELITQSSP Ppu SADAALKHIVDGFLRFHHDVFPDQQELFKKLAT-AQTPRAMFITCADSRIVPELITQSSP Pae SADDALKRIVDGFQHFRREVFPEQQALFKKLAN-SQRPRAMFITCADSRIVPELITQSSP Avi NAEVALKNIVDGFHRFRTEVFPQQKEFYRSLAS-AQRPRAMFITCADSRIVPELITQSAP Nar --MTIVNELIGRVFSFEKTVFPDSRELFGKLSTQGQSPKALMISCADSRIVPEQIMQAEP Mfl QEALAILLEGNERFTQNISAHRDLLNVVNIIKDK-QHPFAAILSCSDSRTSTELIFDQSL Lpn1 -----------------------NQIDIKYTAKT-QHPIAVVLACIDSRVPVETIFDMSF Aci --VLRLLKEGNERFVKNERLQRDIYRQIRVTADEGQHPIAAVLGCMDSRAPTEMLFDVGI Neu EQAIQLLKDGNQRFVSNLKLNRNLLQQVNETSEG-QFPFAVILSCIDSRTSAELIFDQGL Lpn2 EKAIELLKEGNKRFVNNLKLNRNLLQQVNETSQG-QFPFAVILSCMDSRTPAELIFDQGL Pir DQVIKILHDGNQRFTSGTRLNRDLGQQVN-ATAAGQNPLAAILSCIDSRVPTELVFDLGV Dps DEILEILQEGNARFRCCALEHPNLCQESRDKLNYSQEPMATVLCCSDSRVPPVHIFDLGL Bsu ----MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDTRLTELLPQAMGL : * *:* Lin --GELFVHRNIANLVIDTDMNL-----MSVLQYSVEVLKVKHIVVCGHYDCGGVKTAID- Chu --GQLFVHRNIANMVVHTDLNL-----LSVVEYAVEVLKVKHIIVCGHYGCGGVAAATK- Vpa --GELFVHRNVANQVIHTDLNC-----LSVVQYAVDVLKVKHIIVCGHYGCGGVNAAID- Vch --GELFVHRNVANQVIHTDLNC-----LSVVQYAVDVLQVKHIIVCGHYGCGGVTAAID- Vvu --GELFVHRNVANQVIHTDLNC-----LSVVQYAVDVLKVKHIIICGHYGCGGVNAAIE- Bfu --GDLFVHRNIANLFQAGDDNS-----ASVLEYAVKVLKVGHVIVCGHYGCGGVRAALLP Bps --GELFVHRNIANIFQPDDDNC-----ASVLEYAVKVLKVDHVIVCGHYGCGGVRASLLP Rso --GDLFVHRNIANLVCPADDNT-----MSVLEYAVRVLKVGHIIVCGHDGCGGVRASLLP Mtu --GDLYTVRNLGNLVPTDPD---DRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLED Nfa --GDLFTIRNIGNLIPSDGL---DTSVDAALAFAVEELGVSTIVVCGHSGCGAMGALLG- Sav --GDLFVVRNVGNLVPPPGEESGDDSVAAAIEYAVDVLEVRSITVCGHSGCGAMQALLSS Sco --GDLFVVRNVGNFVPLPGEESGDDSVAAAIEYAVDVLKVRSITVCGHSGCGAMQALLAA Xax --GELFVYRNIGNVVPPYSQHV--SGVVAAIEYAIAVLGVRHIVICGHTDCGAMKAVLKP Xca --GELFVYRNIGNVVPPYSQHV--SGVVAAIEYAIAVLGVRHIVVCGHTDCGAMKAVLKP Pfl --GDLFVTRNVGNVVPPYGQMN--GGVSTAIEYAVLALGVQHIIICGHSDCGAMRAVLNP Psy --GDLFVTRNVGNVVPPYGQMN--GGVSTALEYAVVALGVQHIIVCGHSDCGAMRAVLNP Ppu --GDLFVTRNVGNVVPPYGQMN--GGVSSAIEYAVMALKVHHIIICGHSDCGAMRAVLNP Pae --GDLFVTRNVGNVVPPYGQMN--GGVSTAIEYAVLALGVHHIIVCGHSDCGAMRAVLDP Avi --GDLFVSRNVGNVVPPYGQIN--GGVSTAIEYAVAALGVHHIVVCGHSDCGAMKAVLDP Nar --GELFVCRNAGNMVPPFATMN--GGVSSTVEYAVVALGVRDIIVCGHSDCGAMKALAAP Mfl --GDLFSVRLAGNIASRKAIGS--------LEYSCKYLGSKLIVVLGHTNCGAVSAACDG Lpn1 --GDLFCVRIAGNVINDDILAS--------IEYACNVVGAKLIMVLGHTRCGAIQSACDG Aci --GDLFSLRIAGNIAGQKVLGS--------LEFACQAKGSKVILVLGHTDCGAVTSACQL Neu --GDIFSCRIAGNILNEDILGS--------MEFACHIAGSKVIVILGHTKCGAVQGVCHG Lpn2 --GDVFSIRVAGNILNDDILGS--------IEFACQVVGVKLIAVVGHTQCGAIKGACDG Pir --GDIFSVRVAGNIVGTKSLGS--------LEYAVGVAGVKLVAVLGHTRCGAVTSSVNL Dps --GDLFVVRVAGNIVNDQIMGS--------IEYAICHLHTPLVIVMSHSNCGAVTAVAKG Bsu KNGDAKIVKNAGAIVSHPFGSV-----MRSILVAIYELQAEEVCIVGHHECGMSGLNASS *: : . : : : : .* *. Lin -GKYHG-LIDAWLRHIKQVYRMNR---------------------KELSGILDENEKHER Chu -NNSFG-YVDNWLRNIKEIYNKNT---------------------VELLAIENEEERINR Vpa -NPQLG-LINNWLLHIRDLYFKHR---------------------SYLDQMPVE-DRADK Vch -NPQLG-LINNWLLHIRDYYLKHR---------------------EYLDQMPAE-DRSDK Vvu -NPRLG-LINNWLLHIRDLYLKHR---------------------NWLGELPKE-KWGDK Bfu PEPGLP-HVNRRIAPLCALARAHH---------------------EELDGHANERQRIDR Bps PSPELP-HVNRRIAPLCALAGRHR---------------------AELDGVP-PDAAADR Rso QSDALP-HVNRRIGPLCALAVRHR---------------------AELDAVPDMDDRVNR Mtu DPANTTTPMMRWLENAHDSLVVFR-----------------NHHPARRSAESAGYPEADQ Nfa KPTKNSPAVRDWLAHAEPSLRAYH-----------------DNHPVAAAAEAAGFDAYDQ Sav DPGSSQTPLKRWLRYGLPSLER------------------MAAEDRARLAGRAAADAVEE Sco EPGGARTPLQRWLRHGLPSLERALPDVDVDVDLNEQEQKRGAGRARPRLAGRGAADTAER Xax ESLEDVPSVAAWLKHTDAARHVTA----------------------HHGHDPQSPDALNC Xca ESLEDVPSVAAWLKHTDAARHVTA----------------------HHGHDPASQEALSC Pfl DSLEKMPTVKAWLRHAEVAKTMVH----------------------DNCNCTDEKESMPI Psy SSLDKMPTVKAWLRHAEVARTVVE----------------------QNCNCSGELETMQV Ppu QSLTKMPTVGAWLRHAEVARTVVE----------------------NNCSCGSEHETMQV Pae QTLERMPTVKAWLRHAEVARTVVA----------------------DNCDCGASHDTLGV Avi PTLESMPTVKAWLRHAEVAKTVVL----------------------ENRCSCNGRDTLEV Nar ELPQGMPNVVAWLRHGSAAEHVVS----------------------SCSPHLHGNERVRA Mfl ----------FSGGHIGEITKMIFPAVEAEKE-------------TKENRSSSNKAFVSH Lpn1 ----------IEKGHITQLLSKIKPAVNAEKE-------------TTTERNGKNQTFVNH Aci RLQHKQISDIQEMPHIQYVLGPLMHSVGSVFD-------------IMQPRE-LSKAFIDQ Neu ----------IKLGNLTALLDKLQPVVDAELS-------------GKNISDISDPEFMEN Lpn2 ----------VKLGNLTNLLNKISPVIQEAKK-------------LDSKHDVHSPEFLNC Pir VAANQGAEAATGCQHLQPIVDEIAPCIPSDVTR-----------AIENLSEEAMEQYVDK Dps TNLGG---------HMASLVPAIQTALKT--------------------VEGMEGGRVDN Bsu ILEKAKERGVEDSCLNLLTSAG---------------------------LDLKTWLTGFH Lin LVELNVREQVYNLCMTTIVQNAWSRGNDLQLHGWVYDLKQGKILDLNIDIDKDFRDYDIF Chu LVELNVVEQVRNLAKTKPVQRAWKN-RALEIHGWVYGLDTGIIKDLHSLYDEAEDLEPIF Vpa LGEINVAEQVYNLGNSTIMQNAWERGQDVEIHGVVYGIEDGRLEYLGIRSNSKETVEASY Vch LAEINVAEQVYNLANSTVLQNAWERGQAVEVHGFVYGIEDGRLEYLGVRCASRSAVEDNY Vvu LCEINVAEQVYNLGNSTIMESAWERGQDVEIHGVVYGIGDGRLQDIGVRCYSRESLEVNY Bfu LAELNVLEQVRGLRAHPVVR---DADPAPLVHGWIFALEDGRIKVLSSGYEADDAMTCTT Bps LAELNVLEQVRLLRSSPIIR---DAAPAPLVHGWIFSLADGRLKELASGYPAAQRPPQAE Rso LAELNVLEQVRWLRESSIVR---EAEPAPRVHGWIFGLADGRIRVLGSGEPGEAPPVRGD Mtu LSIVNVAVQVERLTRHPILATA-VAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADR Nfa LAIVNVAVQIATATQHPSLVSA-VAQGQVQIVGLFFDIATATVWHVSPTTVTAHHNQLAT Sav LCLTNVVQQLAHLRAHESVARA-LREGALELHGMYFHVGEAQAYLLSEDPAADGVFARVT Sco LCLANVVQQLEHLRAHDSVARA-LGAGDLELHGMYFHVGEAQSYLLSEDAEGS-VFELVR Xax MTEENVVSQLDHLRTQPVVAAR-LAAGTLRIHGWIYDIAHGEIRAFDAEKGGFRPLLAES Xca MTEENVVSQLDHLRTQPVVAAR-LAAGTLRIHGWIYDIAHGEIRAFDAEKGGFRPLLGET Pfl LTEENVIAQLQHLRTHPSVASR-MANGHLFIHGWVYNIETSEIKAYDADQGCFLPLDGSH Psy LTQENVISQLHHLRTHPSVAAK-MASGQLFIHGWVYSIETSEILAYDAERDTFVPLDGTG Ppu LTKENVIAQLHHLRTHPSVASR-LAAGELFIHGWVYDIETSKIEAYDAASDSFLPLAAGE Pae LTEENVVAQLDHLRTHPSVASR-LASGQLFIHGWVYDIESAQIRAYDAKQGRFLPLDGEH Avi LTEENVVAQLDHLRTHPSVAAR-LASGQLFIHGWVYSIETAEIKAYDAEQGCFRPLDSEG Nar VSLQNIIAQIAHLRTHPSVAAA-IARGEMALHGWFVDISAGMVLGLDGDTGQFVPLREDR Mfl VCKLNVKTQIDNIWNSSEILRDLLNQGKIGIVGGIYDLATAKVSFPEAYQIFSADHP--- Lpn1 VTELNVANTLQNIYKKSDILRTMIDSNEIGMVGAIYDVSSGKVSCKTYTEELSTLDGDEN Aci VTAMNVHYNIQYIIQHSSVLKDMLDRKEIDIVGAIYDVKTGKVNFL-------------- Neu VARLNVHYVINEIPKRSQVIAEMLGNGKVALVGGMYDVDTGIVTFYDK------------ Lpn2 VTSLNVKHTMNEIKQRSNIVHQLLDEKRIAIVGGLYQLETGEVQFFDE------------ Pir VAEDNVMHTVDEIVKRSRIIREAVEAGRVKVIGALYDVKSGHTKFLGDSVSGVIPDSSSG Dps AAQQVALLMADLIRESEPIISDLVLEGKVKVVPAYYDLTTGKVEFLEL------------ Bsu SVEESVSHSVNMIKNHPLLPKK------VPVHGLVIHPETGKLDVVINGYETELINNHS- : : . Lin RYQFETH--------------- Chu RYTFED---------------- Vpa QKALSTILNPDNKLLCR----- Vch HKALEKILNPNHRLLCR----- Vvu QAAMAKILNSDVMKFHE----- Bfu AAHSAA---------------- Bps RAQAAAA--------------- Rso ILEPAEAEA------------- Mtu PVDHESAQ-------------- Nfa STVHA----------------- Sav ETARDDMPA------------- Sco ETNLTA---------------- Xax -TPEATPRPRLQQVVRAELA-- Xca -TPEATPRPRLQQAVRAELV-- Pfl PIPVATPKARF----------- Psy PTPMASPKARFSAD-------- Ppu PVPCATPRGRY----------- Pae PVPMATPAPRYLSS-------- Avi SIPVATPRPRFHQG-------- Nar SLPVALPAQPRAASEPLVEAAE Mfl --LVQN---------------- Lpn1 KLLAQKFETILLEAKAS----- Aci ---------------------- Neu ---------------------- Lpn2 ---------------------- Pir QTAEVAG--------------- Dps ---------------------- Bsu ----------------------