Fig. S1. CLUSTAL X (1.81) multiple sequence alignment Neu -------------------------------MMKLGNLQNHMILRDLYASIVVFFVALPL Lpn2 ----------------------MEFKRITKYEAIMKHGLFAHLKHDLPASIVVFFVALPL Chu ------------------------------------MLSTKESLKDIQAGVVVFLVAIPL Lin -------------------MALKPKEHIMNILYSFPRVSWDNLRHDFSAGLVVFLISLPL Pir -------------------------MSTSEAQTPTSIFSPSTILQDLISGLVVFLVALPL Aci ---------------------------MNGYFMTIFQVRNKFHIKDALSGLVVFLVALPL Lpn1 -----------------------MIDRNIVNLRLFRIYSKRYLKFDFVAAIVVFLVAIPL Bfu ---------------------------------MNLRAFFSTFQRDLLAGTVVFLVALPL Bps --------------------------------MKNLRASFSTFPRDFVAGTVVFLVALPL Rso ---------------------------------MQTPTQPAFFPRDMLAGTIVFFVALPL Mtu ------------MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPL Nfa --------------MSQAEAPESADDLHTSPSSPSRDRLRGILRHDLPSSVVVFLVALPL Sav --------MSACVPTRAADSNRTKRIHQPHSPPPPQPRRFRIAGADWSASIAVFLIALPL Sco ---------MSACVPARADSARTKHVHPPHSPPPHGPRRFRVAGADVSAAIAVFLIALPL Xax ----------------------------MNTSGIGGYFRQGLFGRDLLASVVVFLVALPL Xca ----------------------------MNTAGIGGYFRQGLFGRDLLASVVVFLVALPL Pfl ---------------------------------MRAAQLKAVLPRELLASVVVFLVALPL Psy ---------------------------------MGIRELKSALPRELLASVVVFLVALPL Ppu --------------------------------------MKAALPRELLASVVVFLVALPL Pae -----------------------------MHVSKVFPSLRDTLPRDLMASVVVFLVALPL Avi MIGLVFTSSDAPLRSHSPQRGRLVFDSHTEETSMNLETLKSTLPRDAMASVVVFLVALPL Nar ------------------------MSTAATAAQAEGSGPFRFLARDFTASIVVFLVAMPL Mfl ---------------------------------------------------MVFLVAVPL **::::** Neu CLGIAMASGAPLFSGIIAGIVGGIIVGMASGSQLGVSGPAAGLAVIVLNAIATLG-SWEA Lpn2 CLGIALASHVPLFSGIIAGVIGGVVVGFISGSALGVSGPAAGLVAIVISSVETLG-SWEA Chu CLGIALAQNAPPFSGIISGIIGGSIVTLISGAKYSISGPTAGMTAIMISSIKELG-TFEL Lin CIGIGFASGAPIVSGLISGIVGGIVISLISKSPLSVSGPAAGLTVIVFDSIKTLG-NFND Pir CLGIALASGADLFSGLLAGIVGGLVVAAISGSHTSVSGPAAGLTAIVAAQIASLG-SFEA Aci CLGIALASGAPILSGIIAGIVGGIVVGILSGSHISVAGPAAGLTAVILVQLEQLGGNYAA Lpn1 CLGIALASGAPLFSGILSGIIGGIVVGIFSGSQVSVSGPAAGMAAVVLAAISQLG-DFNT Bfu CLGIANASGVEPFAGLVSGIVGGLVVAVLSGSRLSVSGPAAGLVVIVIDGIAQLG-SFSA Bps CLGIANASGVEPFAGLVSGIVGGLVVAVLSGSPLSVSGPAAGLVVIVVDGIAQLG-SFQA Rso CLGIASASGVDPLAGLMSGMIGGLVVALLSGSQLSVSGPAAGLVVIVVDGIAKLG-GFSA Mtu SLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDELG--WPM Nfa SLGIAIASDAPIMAGLIAAVIGGIVAGAVGGSPMLASGPAAGLTVVVAELVAKFG--WQV Sav SLGIALATGAPLQSGLVAAAVGGLLAGRLGGSPLQVSGPAAGLTVVTAELIHRYG--WRT Sco SLGIALATGAPLQAGLVAAAVGGIVAGRIGGCPLQVSGPAAGLTVVTADLIQHYG--WRT Xax CMGIAIASGMPPAAGLITGIVGGLVVGFLAGSPLQVSGPAAGLAVLVFELVREHG--AVA Xca CMGIAIASGMPPATGLITGIIGGLVVGFLAGSPLQVSGPAAGLAVLVFELVREHG--AAA Pfl CMGIAIASGLPPAKGLITGIIGGLVVGWLAGSPLQVSGPAAGLAVLVFELVRQHG--IEM Psy CMGIAIASGMPPAKGLITGIVGGLVVGWIAGSPLQVSGPAAGLAVLVFEVVREHG--MAM Ppu CMGIAIASGMPPAKGLITGIIGGIVVGFLAGSPLQVSGPAAGLAVLVFELVRQHG--MAM Pae CMGIAIASGMPPAKGLLTGIVGGLVVGFLAGSPLQVSGPAAGLAVLVFELVRTYG--VAM Avi CMGVAIASGMPPAKGLITGIIGGLVVGWLAGAPLQVSGPAAGLAVLVFELVRQHG--IAM Nar CMGIAIASGVPPEKGLVTGIIGGIVVGVLAGSPLQVSGPAAGLAVIVFEFVRDNG--LSA Mfl CLGIAIASGLPPTAGIITGIIGGLVVGSISGSPLTVSGPAAGLVVIVADIVAEFG--LAI .:*:. * *:::. :** : . . :**:**:..: : * Neu FLLSVMLAGVLQIGMGYLRLGAIAYYFPVSVIKGMLSGIGLVIILKQIPHALGYDRDFEG Lpn2 FLLAGVIAGILQLIAGFLRGGIIAYYFPSSVIKGMLTGIGIIIVLKQIPHLLGHD---VT Chu VLTAIAIAGIIQILFGVLRVGIIGHYFPSSVIKGMLSAIGIILIIKQIPHLIGYDVDPEG Lin FLLALCLAGIFQIILGFLKAGILSNFFPSAVVKGMLAAIGVVLILKQIPHAIGYDIDYEG Pir FLLAVLIAGVIQIIFGIARGGALSAFFPSSVIKGLLVAIGVILILKQIPHIFGHDTDPEG Aci FLLCIILAGFLQILFGLFKLGFFANFIPNNVILGLLAAIGVILMMTQIPYLMGLSDFS-- Lpn1 FLLALTIAGLLQMIIGALRAGFVADYVPSNVVQGLLCSIGILLIIKQLPLAFTLSSDFDE Bfu FLLAVLLSGAIQFGFGMLKAGRFAAYVPSPVIKGMLAAIGVLLIVKQFPLALGLSGADAA Bps FLLAVLLSGVIQFGFGLLKAGRFAAYVPSPVIKGMLAAIGILLIVKQVPFALGLS----- Rso FLMAVLLSGVLQFVFGMLRAGRFAAYVPSSVIKGMLAAIGLLLIIKQVPLAFGFARADAA Mtu LCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGGTSHSSA Nfa TCAITVAAGALQILFGLSRIARAALAISPVVVHAMLAGIGITIALQQVHVLLGGTSRSSV Sav TCAITVLAGVAQLGLGCLRVARTALAVSPAIVHGMLAGIGVTIAVAQLHIVLGGTPQSSV Sco TCAITVFAGIAQLGLGCLRVARSALAVSPAIVHGMLAGIGVTIAVAQLHIVLGGTPQSSV Xax LGPVILVAGAIQLIAGLCRAGVWFRMTSPAVVAGMLSGIGILIVASQAHVLMDAAPKARG Xca LGPVILVAGAIQLVAGLCRAGVWFRMTSPAVVAGMLSGIGILIVASQAHVLMDAAPKARG Pfl LGPILLLAGFLQLVAGRLKLGCWFRVTAPAVVYGMLAGIGVLIVLSQVHVMLDASPKPSG Psy LGPILLLAGLLQLLAGRFKLGCWFRVTAPAVVYGMLAGIGVLIVLSQAHVMFDSGPKPSG Ppu LGPILLLAGLLQLLAGRLRLGCWFRVTAPAVVYGMLAGIGVLIVLSQVHVMFDTAPQPSG Pae LGPILLLAGAIQLLAGRLRLGCWFRVTSPAVVYGMLAGIGILIVLSQLHVMLDLAPKASG Avi LGPILLLAGLIQLLAGRLRLGCWFRVTAPAVVYGMLAGIGILIILSQLHVMLDASPQASG Nar LGPVLVLAGALQFVAGVARLGGVFRAISPAVVHGMLAGIGALIVIGQFHILFDAKPMSSG Mfl YGVIVLAAGLVQILAGVFKLGVWFRAISPAVIHGMLGGIGILIIGSQFHIMLDRDPLSSG :* *: * : . . :: .:* .** : * : Neu DLAFFSPDGESTLGYLVDTLY-DVSPAAILVTVISMSILLLWEMVLYKKYRIFQILQGPL Lpn2 PLLLSMSDGELDINDIREALD-DINPEVVIISIVSLLTLIFWEK-LVKKHKLFEMIQGPL Chu DMTFFQDDGRNTFTELINMLN-YFTPGPAIISAISIIILLFWNSDYIRPGSKLSFVPSAL Lin DMGFFQKDRENTFSEILTAFY-RFTPGAIILFTVALVLILIWEKFKLHEK---FIIHGSL Pir EMSFIQPDQENTFSELLTIFAGEIHIGAMVIGFLSIAILLVWER---IPALKKSLVPAPL Aci --------WSQLWSGQLDQVMSQIDLGAMLIGFLSLLLILAWD----SSPLKKWVLPSAL Lpn1 LKTHLLETTEGFTVSPLLALSQHINEGALIITTLSLAILIYFDI---TKNKILKEIPAPI Bfu SAAQPVAQAAGSIGTPFGSVS----LAACVITLLSLAILVGWETRALRRFALVRRVPAPL Bps -----------GDGDAPGHAV----FASSAIALASLALLAVWETRAMRRFAFVRLVPAPL Rso AAAG-------AIVTPFGSVS----AAAMAVTALSAAVLIGWETRALRRFLLVRALPAPL Mtu WRNIVALPDGILHHELHE----------VIVGGTVIAILLMWSKLP----AKVRIIPGPL Nfa WQNLSQLPAQLTRLHWGD----------LTIGLIVIVTLLSWKKVP----GALGRIPGAL Sav LANLHALPAQLAHLQPAA----------VSMSALTLALLLAWPRLPGRVGRLLRTIPAAL Sco PDNLVALPAQLANLHPAD----------LAVSVLTLTLLLLWPRIPGRAGQALGKLPAAL Xax LENFAALPGVLWQAISEG-----TGRNALFVGLATIGIILAWDKLRP---QRLRFLPGAL Xca LENFAALPAVLWQAISEG-----TGRTALLVGLATIGIILAWDKLRP---QRLRFLPGAL Pfl LDNLTAFPGAVAQALPS------LGWQAGLLGLSTIAVMWLWEKFRP---HSLRFIPGAL Psy LDNLIGFPATLVQAIGPG-----TGMQAGMLGLGTMLIMWGWEKLRP---QSLRFVPGAL Ppu LQNLLEFPATLSAALPQESTG--AGWMAGALGLGTIAIMWGWERLRP---QRLRFVPGAL Pae LDNLLAFPQAAFAALGSLGMD--SGLDAALLGLGTIAVMWGWDKLRP---QRLRFLPGAL Avi LTNLQAFPAALLDALPFGE-G--SGWSAGLLGLLTIGTMWLWDKRKP---ARLRFLPGAL Nar IENLAMMPARVLGLTPFDLR---STELALMLGLLTIGTMIAWDKLKP---SKVSLVPGAL Mfl IANLIDIPNGLLETFESHG----GNIYAAITGIITIVAIVLWTRFAP---AKLKLIPGAL : : : ..: Neu VVVAIGILLSYLFDEYIESLNFETD-----DLVNLPVALSIQDFAGQFT----FPDFSHL Lpn2 VVVILGIALNLFYEHRLTSFSLDPS-----ELVQLPKFNKASELFNYLT----LPDFSLI Chu IIVAAGLLLNLLFEFVFPSLLVHQN-----HLVAIPTIKNTGDLLNSLI----FPDLNGL Lin VAIVTGVLLNEMFRIFELGIVVSGE-----HLIQPIQLNGALDLFLDDY----SPNFSQW Pir IVVVVGVLLNLGFTNMGQDWLVSES-----HLVQIPIAQSFSEFFGFLR----LPDFSRT Aci IAVVAAALLNYLLVYFQSPWAIQPN-----NLIQLPKILDAPESVMIY------PDFSAL Lpn1 LVVLAGILLNELFIWTNSSLAQNSP-----QLVNIPDTNGFFQFFSHLE----YPDWSAW Bfu AVVLLGIGATLLLSVLAPSLAPPAE-----HRVALPPLESFAALQLALEWADFGPHFAQL Bps AVVILGIGATVLLGFVSPSFAPPAE-----HRVALPELASFAALGEALKTVDLGPNFAYL Rso MVVALGIGVTLLLDAVAPGVAPPVE-----HRVGLPSLASFGALFDALQ----SPSLDAL Mtu VAIAGATVLALLPVLQTERIDLQGN------FFDAIGLPKLAEMSPGGQPWS-------H Nfa VAVVAATAVSLVVPLGVERIVMNGS------LFDAIALPALPDG---------------- Sav VAVAGATTAASLAALSLPKVDLP--------SWRSHALASLPEG---------------- Sco IAVAGATAVAALTGLRLPKVDLP--------SWSSHALASLPDG---------------- Xax IAVVVVTATVQLQGLNVNKVDVPTN------LFSAISIPSISDIFGVFNH---------- Xca IAVVVVTATVQLQGLNVNKVDVPTN------LFSAISIPRLSDIFGVFNH---------- Pfl LGVGLATGASLLLALQVKRVEVPEN------LAEAIDWLKPADLLSLADP---------- Psy LGVGIATGISLFMALQVKRVEVPDN------LADAIDWLRPADLMNLADP---------- Ppu LGVASMTAISMWLALPVNRVQVPAD------LSEAIDWLRPEDLLQLADP---------- Pae LGVSLATLASLWLALDVRRVEVPAN------LGEAIVWLRPADLLALADP---------- Avi LGVSLATLVSLVFSMDVHRVEVPAN------LGDAIDWVQPADLLRLLTEP--------- Nar LGVLAATAVAWGAGLDVARITVPDS------IAAAFALPDGGFLGPLTQP---------- Mfl IGVVLAVIVANLFNFDIKYLTDLFDGPTDLQNILGTIITPTMSTIEASMTT--------- : Neu ANPEIYFIALVIAVIASLETLLCVEATDKLDPLK-------RVTSTNRELVAQGLGNTVS Lpn2 THLKIYKIAILIALIASLETLLCVEAVDKLDPYK-------RVTSTDRELKAQGVGNILS Chu NNYRTYAIGFTIAVVVSLESLLSIDATDKLKKEN-------NPSPTNRELIAQGVGNLSC Lin KNQTIYFIAIKLCLVMSLETLLNLDAIEKIDPQR-------RIVSKNRELVAQGTGNLCS Pir FDPAIYIAAVTIAVVASLETLLNLEAVDKLDKAK-------RNSPPSRELIAQGCGNMVC Aci SNPLIYTGAITLAVVASLETLLNLEAADKLDPQK-------RSSPPNRELWAQGTGNIVS Lpn1 TNPKVYLYALVICIVASLETLLNLKASERLDKKR-------RHSPTNQELVAQGLGNITS Bfu VNPDVWRVAITLAIVASLETLLSLEAVEQIDPER-------RPAPPDRELKAQGVGNLIA Bps LSPDVWRIAITIAVVASLETLLSLEAVEQIDPKR-------RPSQPNRELKAQGVGNLVA Rso TNPDVWQLALALAIVASLETLLSLEAVEQIDPKK-------RPAPADRELKAQGIGNMMA Mtu EISAIALGVLTIALIASVESLLSAVGVDKLHHG--------PRTDFNREMVGQGSANVVS Nfa KWLAVATGVLTVALIASVESLLSAVAVDKMHSG--------ARTDLNRELIGQGTANIAS Sav PVLGIAAAVLTTTLVCSVQSLLGAVAVDKLTAGRPLPN---RRSDLDRELLGQGTANIVS Sco PVLGLVAAVLTTTLVCSVQSLLGAVAVDKLVAARPSLTGRVKRSDLDRELLGQGAANIVS Xax ---TLLVSAVTFAFIASAETLLSAAAVDRMHQG--------ARTQYDRELAAQGVGNMLC Xca ---TLLVSAVTFAFIASAETLLSAAAVDRMHQG--------ARTQYDRELAAQGVGNMLC Pfl ---TLLIAAFAVAFIASAETLLSAAAVDRMHSG--------PRSDFDRELSAQGVGNMLC Psy ---AILVAAIVVAFIASAETLLSASAVDRMHSG--------ERSDFDKELSAQGVGNMLC Ppu ---TLLVAAFALAFIASAETLLSAAAVDRMHSG--------QRSDFDRELSAQGIGNMLC Pae ---SLLLAAVVVAFIASAETLLSAAAVDRLHDG--------PRSDMDRELSAQGVGNMLC Avi ---SLLIAALTLAFIASAETLLSAAAVDRMHQG--------PRADFDRELTSQGIGNMLC Nar ---SLIVSAIAIAFIASAETLLSAAAVDRMHDG--------VRTDYNKELRAQGIGNLLC Mfl ---GVLLAVVSLAFIASAESLLSCAAVDQMHQG--------VRTKYDRELMAQGVGNAIC . .: * ::** . ::: .:*: .** .* . Neu GLIGGLPVTQVIVRSSANITFGGRTKLSAIFHGVLLLICVIVIPGVLNMIPLASLACILF Lpn2 CLIGGLPITQVIVRSSANVAFGAKSKLSAILHGLLLFICVISIPEILNEIPLASLASILI Chu GLIGGVPMTSAIIRSSANINAGATSKLSSYVHGFLLLTSVLLFPDLLTSIPNASLAVILL Lin AILGGLPITSVIIRSSANLHAGARTRFSSFLHGLLILVSVILIPVWIAKIPLASLAAVLL Pir GLIGGLPVTSVVVRGSVNVASGSKTKMSAIFHGGLLLVSVAFLPTLMNKIPLSALAAILL Aci GFIGGMPITSVIVRSSVNANTGARSKCSTIIHGVLLLLAVLFFVPLMNMIPLSALAAILI Lpn1 GLVGGIPVTSVIVRTSINIHAGSKTKFSAVLHGFFILFAVMLIPGALNKIPLSSLAAILI Bfu GAIGGLPITSVIVRSSANVHAGAQSRLSAIIHGVLLLVSVFALTSVINLIPLACLAAILI Bps GAIGGLPITSVIVRSSVNVNAGAQSRMSAIVHGVMLVVSVFALTWLLNLIPLASLAAILI Rso GVFGALPITSVIVRSSANVQAGAQSRWSAVVHGALLLASVFTLTSIVNLIPLACLATILI Mtu GLLGGLPITGVIVRSSANVAAGARTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLI Nfa GMLGGLPITGVIVRSATNVAAGAKSKASTILHGVWILLFSVLLAGVVQQIPKAALAGLLI Sav GALGGLPVAGVAVRTSANVRAGAVSRNSTMLHGVWVVVAALLMVPILELIPLASLAALVM Sco GSLGGLPIAGVAVRSSANVAAGAVSRNSTMLHGVLVVIAALLMVPALELIPLASLAALVM Xax GFLGALPMTGVIVRSAANVQAGAATRASTILHGSWLLVFAMLLPWLLRMTPVACLAGILV Xca GFLGALPMTGVIVRSAANVQAGAATRVSTILHGSWLLVFAMLLPWLLRMTPVACLAGILV Pfl GLVGALPMTGVIVRSSANVQAGATTRYSTIFHGLWLLAFVLLLSSLLQSIPVASLAGVLV Psy GLLGALPMTGVIVRSSANVQAGAKTRYSTILHGTWLLAFVLLLSSVLQSIPVASLAGVLV Ppu GVLGALPMTGVIVRSSANVQAGAQTRASAIFHGLWLLAFVVALSSVLQQIPVASLAGVLV Pae GLLGALPMTGVIVRSSANVNAGARTRASAIFHGLWLLAFVLLLGSLLRQIPVASLAGVLV Avi GLLGALPMTGVIVRSSANVQAGAVTRLSAVLHGLWLLAFVLLLTAVLQSIPVASLAGVLV Nar GVVNALPMTGVIVRSSANVQAGAKTRWSAVAHGAWILGFVALLPWLLREVPMAALGGVLV Mfl GFLSALPMTGVIVRSSANVEAGATSRVSTILHGLWLLLFISVFLFTLEYIPVATLAGVLV ...:*:: . :* : * *. :: *: ** :. : : * : *. ::. Neu VVGYNLAKPSLFKAMYELG-WTQFAPFIATVIGILLTDLLKGIGIGMVVAIFFILRSNLK Lpn2 IIGYKLAKPALFKQMYKMG-WEQFVPFMITIIGIIFSDLLFGITLGFSLAIFIILRHHFL Chu FTGYKLTKVSLFKSMYALG-PKQFIPFITTISVMLLTDMLKGIICGLSIALFYILRDMMR Lin VVGYKLTDYKILQTQYKKG-MDQFLPFISTLVGIVFTDILVGIGIGCLFSVFFIMRRNIL Pir VTGFKLASPAIFKQMWKEG-RYQFTPFIITVIAIVVTDLLIGILIGLAISVLFILNSNLR Aci LTGFKLTHPKMFKKLYQQG-WKQFIPFIITLVAILLTDLLIGILIGLATSIAFILYGNLH Lpn1 YTGYKLNKPAIYINIFSQG-SDRFIPFIVTVISIIAFNLLAGILIGLAISLFYILKSNSQ Bfu FTGLKLAKPSLFAAVAKQG-FAPFAPFIVTLVGVLATDLLIGIVLGILCSVLLALYANLR Bps HTGFKLAKPALFTSVAKQG-PGAFLPFAVTIAGVLAIDLLAGIALGLACSVFAVACANLR Rso FTGFKLAKPSLFVSVARQG-MERFAPFIVTIVGVLLTDLLIGILMGIALSIALAIRANLR Mtu VIGAQLVKLAHIKLAWRTG---NFVIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVR Nfa VIGIQLVKLAHIRLAHRTG---DLWVYLITVAGVMFLNLLEGVLIGLIVAIALFVWRAAR Sav AVGIQMVSLHHIRTVTRHR---EVLVYAVTTLGVVLLGVLEGVTLGVAVAVAVALNRLAR Sco AVGLKMVSLNHIRTVTRHR---EVLVYAVTTCGVVFLGVLEGVALGIAVAVGVALHRLTR Xax YTGVKMIKIGQVKELATYG-RGTAAIYLATTFAIVATDLLTGVLIGFGLSLFRLALHSSR Xca YTGVKMIKIGQVKELATYG-RGTAAIYLATTFAIVATDLLTGVLIGFGLSLFRLALHSSR Pfl YTGFKLVNLKAFRGLGRYG-RMPMFTYAATALAIIFTDLLTGVLIGFGLTLLKLAFKASR Psy YTGLKLVDLKAFRGLGRYG-RMPMFTYAATAVAIVFTDLLTGVLIGFGLTLVKLAFKASR Ppu FTGVKLVDFKAFRGLGRYG-RMPMFTYAATALAIIFTDLLTGVLLGFALTLLKLAFKAAR Pae YTGVKLVDFKALGNLSRYG-RMPMLVYAATALAIVFTDLLTGVLVGFALTLLKLVLKAAR Avi YTGVKLVDLKALRGLGRYG-RMPMFVYAATALAIVCTDLLTGVMIGFALTLAKLAWRASR Nar VTGWKLVSLKHVSHLFRAHGVMPALIWVATFLLVVTTDLLTGVLVGLALSALELLPHVRN Mfl YTGYKLAYPKVAKELLSYG-KAELAIYIITIVTIVSFNLLAGVVTGLVLSIAKLLYVFSH * :: : * :: .:* *: * : Neu TDYELFHEKNDGVKKIRLVLAEDVSFLNKGSIGKALKEFEPDSWVIIDGSESKYIDHDII Lpn2 NSHDMIKTRGKNKTQYCLKLAEEVTFLNKGSIINELKNIPEGAEVVIDGSRSKIIDHDIK Chu IPIKKSSAIIEGKEHALITFPENVSFINKGFLFKMLEALPKQSSVILDGTNIKSIDYDVL Lin NPYQFNKKEMAYGVEVKIDLSEDVSFLNKSS----------------------------- Pir RPIRRIVETQVDGDVTHIELSNQVSFLNRAALDRVLNESQPGGKL--------------- Aci KGVRVYKEKHLHGVITRIELPSQVTFLNRAALISALDRVHRNEKLVIDATQSDSIDSDIY Lpn1 ARIDIIKEIYPNGSTYRLMLPQQMTFLNKAALVAELDTLPRRSQLIIDARHSQYIDKEIL Bfu SPIVLAQ----HGDHYLLSFRKDVSFLGKVPLKHYLQQIPDGATVIVDATRADFVDHDVR Bps SPATLAQ----HDDHYLLSFRKDVSFLGKVQIKQYLAQIPDRAVVIIDATRADYIDHDVR Rso RSIVMAR----HHDHFLLSFRKDVSFMGKVPLKRYLAQVPDYTTLIIDASRADYIDPDVR Mtu APVEVKPVGGEQSKRWRVDIDGTLSFLLLPRLTTVLSKLPEGSEVTLNLNAD-------- Nfa ADIHAEPVGDLDSLRWRVVIEGSCSFLSLPKLSSTLDSVPEGADVTIELTVDFIDHAATE Sav TRITHDEQEG----VHYVQVRGQLTFLAVPRLSRALHLVPHGADAVVELDGSF------- Sco TRITHDETEG----VHHVHVRGQLTFLAVPRLSRVLHQVPHGADAVVELDGS-------- Xax LKVEVREHADK-KDEMHLTLQGSATFLKVPAMARTLESVPPNTALHLDVAKLHHVDHACI Xca LKVEVREHADK-KDEMHLTLQGSATFLKVPAMARTLESVPPNTVLHLDVAKLHHVDHACI Pfl LKISLIDLPQ--EGEMELRLVGAATFLKVPALTQVLGSIPPGTTVHVPLNNLSYIDHSCL Psy LKINVVPLAG--EKECELRLVGAATFLKVPALTQALATIPQGSTVHVPLGNLSYIDHSCL Ppu LKINLVSLAK--DGHMELRLSGAATFLKVPALTQVLDTVPAGTTLHVPLGNLSYIDHSCL Pae LKIALRYTG---EHEAELRLSGAATFLKVPALSRVLDEVKPGTTLHVPMDNLSYVDHACM Avi LKISLVYDED--GRTAELRMVGSATFLKVPELSRVLATVRPGTQLHVPLDHLNYIDHACM Nar LRFRVGEKPA--GEAVRLELEGAATFLGLTRLTTALEQIPPSKSVHVDMGGVHAIDHTTA Mfl VSIKAEHQPD--SKQTTLHLKGSATQLGIPKLVSVLDHLEPGREIHVLFDDLEYIDHACI : . : : Neu EIIRDFTVNAHIRDINVEVIGIPTLETKSRYQRIMETRYGRPDSPAVKS----------- Lpn2 EVIQNFILNSKTKNIQVKLIGI-------------------------------------- Chu EIIALFKKSAIDKNIDVQLINIHEIDLHLVKK---------------------------- Lin ------------------------------------------------------------ Pir ------------------------------------------------------------ Aci QVIQDYQTETAIKRGIDVKLIGFKQHYAELDDAILDIDISTRDLQCQLSPAD-------- Lpn1 DLFNELKEELAGSKQISVNFTGFQEHYKIHN-YIDFITVTTYDVQTNLTPAQVLNILLEG Bfu ELLDTFVADAPNRGIAVEVRHQVRAQARAARGWSMRRTATE------------------- Bps EMIDAFVAEAPRREITVDYRRQVQHVRGAGLRWFFRNPAAQQAPQ--------------- Rso ELVERFIEDAPSRGILIERHHFDAAAPQPTRASKLLKLRFSRCPAR-------------- Mtu ------------------------------------------------------------ Nfa VLHEWQRRHRDAGGTVLIDELGSHALSATTQGPPQRASSAQARGVEPWKAWQDTNAQAVP Sav ------------------------------------------------------------ Sco ------------------------------------------------------------ Xax ELLRDWSRNAASRGCELVVDWKELDRRVEGQPTVDGVLVEQRVEQAKAA----------- Xca ELLRDWSRNAASRGCELAVDWNELDRRVEGQRKVDPVPTQEPRKAA-------------- Pfl ELLEEWGRANAAKGAKLLIESRGLKRRLEGRIRTTTGIGAAG------------------ Psy ELLEEWGRSNAANGTRLLIEPRGLKRRLEGRVYTTTGIGSGAT----------------- Ppu ELLEDWSRSNSANGSRLLIEQRRLKRRIEGRLRTTAGVGA-------------------- Pae ELLEDWGRMAPVQGSRLVIEPRALKRRLEGRLRGSVGLGGARNGGAVSPG---------- Avi ELLDEWSAASAANGSELVLEPRAVKRRLEGRLRTTVGIGGATA----------------- Nar EMLNEWLSRRRSRGDEVTVTGPAPILKSLAHAA--------------------------- Mfl QLLDGWQKQYQMTGGKVIIEWDSLIGKYHARETAIAEGN--------------------- Neu ---------------------- Lpn2 ---------------------- Chu ---------------------- Lin ---------------------- Pir ---------------------- Aci ---------------------- Lpn1 NQRFLS---------------- Bfu ---------------------- Bps ---------------------- Rso ---------------------- Mtu ---------------------- Nfa HFDALRPMLDGISRYHRRHAPL Sav ---------------------- Sco ---------------------- Xax ---------------------- Xca ---------------------- Pfl ---------------------- Psy ---------------------- Ppu ---------------------- Pae ---------------------- Avi ---------------------- Nar ---------------------- Mfl ----------------------