Fig. S2. CLUSTAL X (1.81) multiple sequence alignment Kla --------------------------------------------------FTSQGFRSSM Sce -----------------------------------------------------NLRFRPR Ego ------------------------------------------------------------ Cne -----------ANEVNEEELGQAPDERSLLLGDGRERKKRSWAGEALSNIEGWKNNLLKV Uma ------------------------------------------------------------ Gze -----------------------------------WFSGFVEVGHRMEERISVAVNPKKW Ncr ----------------------------------------------IASITKVAATPKRW Mgr -------------------------------FLHGLAGVRHSLESHVSAFFRVAREPKCW Ani --------------------------------PKETQRTLPSALTTVSTCFQVLAHPKSW Yli -------------------------------------NHGGPRRGLSGWFKRLEEKIKNT Spo STSRNDFNYRPSEINETRPLLPEREEHSSQLPPAQNQVLPFQSLNAPSKKLRGRISLSKI Bja ----------------------------------------------------MTDPAIIF Sel ---------------------------------------------------------MAW Lpn3 ------------------------------------------------------------ Pol ------------------------------------------------------------ Kla SHYDKARDLMLRIFQYTPAVGLGLLLNILDALSYGMIIFPITEPLFSHLGPTGLSMFYVS Sce NLWHMCTSFPSKFAHYLPAAVLGLLLNILDALSYGMIIFPITEPVFSHLGPTGISMFYIS Ego --PSPLRLWGTRTVRYIPAVILGLLLNILDALSYGMIIFPIAEPIFSHLGPHGLSMFYVS Cne TPKDVVEGIILEPIRTLPSVILGLLLNVLDGVSYGMILFPATP-IFVDFGSLGVSMFFVS Uma ------------------------------------------------------------ Gze DRQALWNNVVLTPTSCLPAVSVGLLLNILDALSYGMILFPLGKPIFSHLGSAGISVFYVS Ncr DRHALWKNVIVTPVKCLPAVIVGLLLNILDALSYGMILFPLANPIFSSLGSAGISIFYIS Mgr DKRAIWQAAVVDPVACLPAVIVGLLLNILDALSYGMILFPLGNPIFSNLGPAGISIFYVS Ani DRRTVWRQGVVRPFSLLPSVFLGLLLNILDALSYGMILFPLGEPIFSHLGSDGISMFYVS Yli SSADMLDECIKKPISYLPSVVLGTLLNILDGLSYGMILFPLSEPIFAHLGPAGLSMFYMS Spo YQFFFDDKGPILFILNIPAVIIGLLLNILDALSYGLILFPISDPLFKNLGADGLAIYYVS Bja SPAARFNPALRRALNDILGGSAASVLAVTFGLSYALLIFTGPLSPYLSYG---IAATFIS Sel VGQRLIADLKSAPLRNILAGLVSGLLLLGENISAGLLIYSNVLSPYLASG----LAALLI Lpn3 ------MRGRMTRSQLILAILAGLVISIDNMISIVAFSSLIYQGALEIYIPLVINILAIS Pol ------------------------------------------------------------ Kla TVICQLCFSLGLSSFPSAIGSEMIEITPFFHTMALSIMNSIPEGNDNKVISTTIVCYALS Sce TIISQAVYSGGWSSFPSGIGSEMIEITPFYHTMALAIKEALAG-NDDEIITTTIFCYVIS Ego TIISQLVYSGGFSSFGYGTGSEMIEVTPFFHTMALSIKNSLSAEKSDDIITTTIVCYALS Cne CIVSQLVFSLGGSIFPGGNGSMMIEAVPFFHILIN-TFEQVCGDDDKAIIATTMVAFAFS Uma -----------------------------------------------------MVAFALS Gze TIVSQITFSSG-SIFKGAVGSELIEVVPFFHNMAGKITEVVGEENPDAVIATTIVSFSVS Ncr TIISQLTFSLG-SVFKGGVGSELIEVVPFFHSMAGTITEIVGEDDPEAVIATTITSYALS Mgr TIVSQLTYSMG-SIFKGSVGSEMIEVVPFFHSMASTITTSIGQDDPDAVIATTIVAYAVS Ani TIIAQLVFSCGGSIFRGGIGSEMIEVVPFFHQMAFTILNRVGQDNPKSVIATTILAFSVS Yli CVVSQLVYSLGGSAFKAGIGSEMIEVVPFFHSMAYTLMAEIKE--PERVIPTVILAFATS Spo CVVSQLVYSLGGSFFKGSVGSEMIEVIPFFHQIAFTILNRVGEDNPKSVIATTILAYCLS Bja SAVLAAVIGLGSSLPFAVAGPDSSTAAVTGILAASLVERIEAANLSAPLLSPVLITLGLS Sel STACLNFFAVNRRGLPYGLATPDSRIYSLLAVIAAAISQSEALADTRMLGVTLLIYWVVA Lpn3 VIIISASYLFMSSPPYAIAQLQDEAAILYSAMGLVIIKSMPSSSTNEAIFITILFMLGVT Pol ---------------MASLAAYVWLVISLTAAAGDAAGHAPRLHLTVAQLAVGLAAGSLM : Kla SIITGLTFFLLGKMRLGKIVGFFPRHILIGCIGGVGYFLIITGLEVC---TRVPEFKYSW Sce SMLTGVVFYALGKLRLGKIVGFFPRHILIGCIGGVGYFLIITGIEVT---TRVAKFEYSW Ego TIITGAVFLTLGKLRLGKLVSFFPLHILIGCIGGVAYFLIITGIEVS---TRVTKFEYSL Cne SILTGLVFFALGAFKLGSLIGYFPRHILVGCIGGVGVFLIETGLEVSRGLK-EEGFEYNL Uma SILTGLAFLLLGALRLGVLIGFFPRHILVGCIGGVGIFLIETGLEVCSRLQSEDGFQYNL Gze AMMTGLVFYLMGRFKVGYMVGFIPRHILIGCIGGVGWFLIATGFEVS--ARLDGSLQYNL Ncr SMLTGTVFYLMGKFKFGYLVGFIPRHILIGCIGGVGWFLIATGFEVT--ARMDGSLNYDL Mgr SMMTGIVFFLMGYFKFGYIVGFIPRHILIGCIGGVGWFLVATGFEVS--ARIEGSLEYDL Ani SVLTGLVFFLMGTCKIGSLIGFFPRHILIGCIGGVGFFLILTGLEVS--ARLPGSFEFDI Yli SVVTGLVFLALGAARLGSLISFFPRHILVGCIGGVGWFLCVTGIEVS--SRMDGPLEYTF Spo SILTGLVFFILGILRLGRLIEFFPRHILLGCIGGVGSFLVLTAVEVS--SRLEGSVSFNW Bja TMLTGIVLCGLGLTRMGRAIRYVPYPVIGGFLGATGLLIVMGAIRVIT------DHPVQF Sel TACIGVALWLMGRCGIGEWLRYIPYPVVGGFLAATGWLLLTGGLNVA------LGFKISG Lpn3 TCLTGLSFYFVGKFRFGNIIRYLPYPVICGFMAATGWLVLSGTFALLT--------GKAL Pol FMVASALVLLCGLLKIGNLFKMIPMPVTAGISNGTALLLLMLGIQTLT------------ . . * .* . .* : * ... :: . Kla QFLSSLFTDFDILLKWLTPVILTLILISVQSRIHNSLVLPSFYIITLLLFHFVVALVPSL Sce PFFSGLFTDYDTLAKWLLPVLLTVVLIGTQRYFKNSLVLPSFYILTLVLFHFIVAIIPTL Ego AFLRNLFMDPDILAKWLIPALLAVSIILLQRRIHNSMLLPLFYLSAFALFHFIVALIPSL Cne ATLKLFFESGHAIALWTIPLALAILLRVITHFWHHQLIFPAYFFIIPVIFYIVIAIGR-W Uma ETLRFFFQSGHMIALWLPPLLLAILLRVITSRFHHPLIFPGYFLMIPVLFYIITTGFLGI Gze DTLKQLSDP-ATVPLWVVPLVLAIILFYGQSKITSKFFLPLFILAIPLIFYFFVLALDTL Ncr DTLKRLIQP-DTIPLWTVPLGLAIILFYGQTKITSKYFLPLYILTIPALFYLVLLILGGP Mgr ATLNKLINP-ETIPLWATPLALAVALVYLQKKIKSTYFLPCFILMIPIVFYIFVFSLDSL Ani PTMQKLFNL-AALALWVTPLLLAIGLLVLKRFVRSNYLVGAYFIVVALCFYIVKFIAHIP Yli AILKFLLDP-QILLMWSTPLALALALLLIQRFSHHPLIVPSYFCGVFAIFHLLVWAIPSW Spo ASLSALFQP-MTFAKWSIPLFLSSALEFAQQRWPHPFLIPSFFVIAPAIFYVLVWAIPGM Bja ATLPRFTNG-VTMSELGAACAMALVLYLTWHRSRNAFGLPIILVGG-MLAAHLAFRIAGI Sel ATLERLWSV-DSAAKILVAVVFGLLLWQLGTRSKRVWITPVLLLAG-LVGAQLVRVGLGY Lpn3 HQNWLVFFHKEEILLWAPGFIAGIVVYIFKEKLGYRYALQLMFISLVILFYALFYIFNLE Pol ----------DNGRLAAFTAVGMVACFVVWPRLLVRAKALNFIPGVVAALLAGVLISMLL Kla SLDKLRDFGWIFAKVNAK--ENWYDFYKLYDFKNVQWSLIPKQVPTMLALTFFGILHVPI Sce SLDALRQAGWIFPIANSD--SKWYDHYRLFNVHKVHWSLVLQQIPTMMALTFFGILHVPI Ego SLDTLRDKGWIFPLTESG--GRWYDYLELYNPQRIHWELVLGEIPTMLALTFFGILHVPI Cne DLQHLRKMGWVFDVGTNT--QAWWKFYTLFDFRKTNWEAFWAAMPTQLALVFFGILHVPL Uma SIQQLRDDGWVFDIGEAASKASFYRFYTYFDFGQTSWRALWATMPTQLALVFFGILHVPL Gze HIDTLRDHGWIFEGPPSG--EPWWYFYTLYKFHLVRWDAVIECVPAMLALTFFGILHVPI Ncr DQDTLQKHGWVFEGPPPG--EPWWYFYTLYKFQKVDWSAIIQCIPAMFALTFFGILHVPI Mgr NPESLRESGWIFEGAASD--EPWWYFYTLYKFHLVRWDVLAETIPAMLALTFFGILHVPI Ani -MDSLRNSGWVFDAPSSS--NPWYHFYTLYDFSAVHWPAFVDTIPAMFALTFFGILHVPI Yli NLQMARDNGWVFSAQATS--EPWWYYYTLYDFGKTDWAALLKTVPAMFALTFFGILHVPI Spo SLEYLRETGWVFSSTETN--VPWYHFYSLFSLRDTDWSALLATVPEMCALTFFGILHVPI Bja SPEEARALGWMFQPPPPAT---FMLPWHIDDLAHYPWFAVPDLLGNVVAVIFVSASSTLF Sel SLAEAAQFGWFLPPLAPR----IVFFWDWPRIPSIDWALLLPQIALIPVLILLAAISLTL Lpn3 YLVDP-TEGYVLGPFNQS----HIDSLMKPEIWQMIHYPFSMTLLNYIGLVILVSFIALL Pol MESPFRSSGAWLAP-----DWAWMSVRLWSELPQHDFARLLKIGLPGVMTLALVMILETF * : . . : Kla NVPALAMSLNVDKYDVDKELIAHGYSNLISGFLGSIQNYLVYTNSVLFIRAGADSPIAGI Sce NVPALAMSLQMDKYDVDRELIAHGYSNFFSGLLGSVQNYLVYTNSVLFIRAGADSPFAGF Ego NVPALAISCGIDKIDVDKELIAHGYSNIFSGCAGSIQNYLVYTNSVLFIRAGADSRYAGF Cne NVPALGVSLSEDNVKLDRELVAHGASNMLAGLTGTVPNYLTYVNTVLFYRVGGGSRLSGL Uma NVPALGVSINEDNVDTDRELVAHGISNLVAGLIGTVPNYLCYVNSVLFYRVGGGSVLSGL Gze NVPALALNCGEDHADLDKELRLHGYSNFLSGCFGSIQNYLVYANTVFFMRSGGNSRLAGY Ncr NVPALAQNIGEDHADLDHELKLHGYSNFLSGCFGSIQNYLVYANSVFFMRSGGNTRLAGI Mgr NVPALAMSAGEDNVDLNHELKLHGYSNFLSGLTGSIQNYLVYANTVMFMRSGANSRLAGF Ani NVPALGISTGEDNLNVDRELIAHGVTNALSGFAGSIQNYLVYTNSLLFIDSGGNSRLAGV Yli NVPALAVSTGQEDINVDRELLAHGISNGLSGLMGSIQNYLVYTNSVLFIKSGADSRVAGV Spo NVPALAISLGLDFVDTDKELIAHGVSNTLSGAVGSIQNYMTYTNSLMFIRSGGNNRLAGI Bja NTTGIEVAAHR-EANLERELNTTGAANILSGALAGYAGCISVSRSILNFSSGGRGRLSGF Sel NLSSLEN-VEKRELDLNQELQRTGLANLIMLPFGGFSPGLLSGSRSTLNRLAGASTPLAA Lpn3 LNASSYELIVNKQLDLNKELRIAGIGNVFSGLLGGMVGYLSLSASTVAKEYGG-ARIIGV Pol TAANEMEQRFGIRINPNRELVVLGGCNIVSALLGGVPCTGHNSRSISSWLAGGRGVYVAL . . ::** * * . . .. . Kla MLTIGTFIVMVIGPVIISFIPICIVGSLIFLLGYELIQEAVID-----------TWGKLQ Sce LLIALTICIMIIGPVIISFIPICIVGSLIFLLGYELLVEALVD-----------TWNKLN Ego LLAIATFMTMTAGPWIISIIPVCIVSSLIFLLGYELLKEVLYD-----------SYNRLS Cne MLAMGTAAIMMIGPAVIASLPVMVVGALIFVLGIDLLMEAVWD-----------TRHRVN Uma MLAGGTAIIMIAGPGTISYLPVMIVGALIFVLGIDLAKEALYD-----------TVGRVN Gze MLAAATFGIMVIGPSLIGYIPVMMVGTLIYDLGFELLLEALWL-----------PRKKLK Ncr MLAVLTFLVMMIGPSLIGFIPVMMVGVLIFDLGFELLIEAVWQ-----------PRKKLK Mgr ELAALTFGVLLVGPRLIGIIPVMMVGCLIFVLGFELLSEALWH-----------PRKKLK Ani MLAGATAGIMLVGPVIVGFIPVMVVGALIFLLGIELMEEALVD-----------TWGKLH Yli MLAIATAGVMFAGPVVIGFIPVCVVGALIFLLGIELLIEALGD-----------TWGRLS Spo MLALATVALLVIGPGIIAYIPVWTVGCLIYLLGIELLKESLWD-----------PIGITT Bja TVAAISLLMLAIAPELLGFMPKFVLGGLLLYLGADQLHKWLIE-----------SRKRLS Sel GVAAVLMLIAIALGDLASWLCKPILAGLLVNIGLVYIDRWVFR-----------SIRLLP Lpn3 MAFVPMLLILCFGAVVVECFPKMAIGCYLFYIAFCFLSEWLIN-----------TWRLLN Pol VGLVFTGVLLLAFGTWLVILPVGMVAGILLLQALLMAEREFFHRLWEIVRTRHWRREGTS : :. : . . . Kla PFEYLTIWIIVITMGVVDFVIGIIVGILLACFSFLVNSTQLQTINGEYDGKVAKSTVYRD Sce RFEYLTVVIIVFTMGIFDFVLGIIVGILIACFSFLVDSTKLQTINGEYNGNVARSTVYRD Ego NFEYITVVIIILTMGIFDFVLGIIVGVLVACFSFLVESTRAKTISSEFDGKVAKSACHRD Cne KMEYITIWAIAIGMTVFDFVIGLLFGIILACIFFVVQSSRRRAIRAVFNGATARSTVRRP Uma GWEYLTIWVIVIVMTYWDFVIGILAGIIIACCFFVVQTSRRKTVRAIFDGSVARSTVRRH Gze LAEYLTVVVIVLVMGIHDFVVGIGVGILLAFVSLILQTSRVSAIRGNYSGDIVTSTVRRN Ncr WLEYMTVLVIVVVMGTYDFVIGIGVGILCAFAALIIQTSRISAVRAIYSGEVVGSTVRRN Mgr TLEYLTVVAIILIMGIYDFVIGIGCGILIAFVTLVFQTSQVSAVRAGWSGDVVGSTVRRN Ani RHEYLTVVIIVATMGVWDFVAGILVGIILACLSFVVQTSRKSAIRATYSGKVAGSTVRRP Yli RFEYITVLAIVLTMGIFDFVYGILFGIVLACFSFVIQSSQRSVIKATYTGAVARSTVRRH Spo KIEYFTICAIVFTMTVVDFVVGIVIGIIMACVFFVIQASSRSALRGIYSGGIVRSTVRRP Bja KLEYLSLVAIIAIIVIWGFVPGILIGVIIGCATFAFSAARVESIKYSFDGAEYRSSLDRS Sel QREYWVTIAILGISIVGGFLEAITAGIVFSSLTFVVSYCRAPAIRSMATGAYLHSNIERV Lpn3 LSEYLIVLLILVIAIVFNMITAVAIGTVISIFIFAFRYSKINPVKYLFSGADYNSSFERN Pol DLGFWTTVVISIVEYFGNMIWACFMGIGLSCLVILRRVSDSLTTKWNYLDRYR-SRRVRT : * .:: . * . : . * * Kla YIQSKFLRNIGEQIYVLKLQNILFFGTIISIEEKVNSLLEICESDSSKKRIKYLILDFKN Sce YVQTKFLDGIGEQIYVLKLQNLLFFGTIISIEEKIERLLQISNKDATKRRIKYLILDFKN Ego YLQSNFLEKVAEQIYVLKLQNNLFFGTIISIEEKIGNLLEPNGSE-YKKIIKYLILDFKH Cne KWQRSFIQQVGSQTYVMKLQGFLFFGTITTVEDEIRKLLDLAKWQHNP------------ Uma MIQRHFLDEVGTQTQIIKLQGFLFFGTINSVEDLIRRALDIA------------------ Gze PSQQRYLHEVGRQIYIAKLTGYLFFGTIVSVEERIRALLEDSAFTAQPIKFLILDMWHVT Ncr PTQQHYLRDAGKQVNIIKLAGYLFFGTIVSVEEKIRAMISDEEFNHRPIRFLIIDLWLVN Mgr PSQQNYLKQVGSQIHVVKLSGYLFFGTIVGVEEKIREIIADETFRQRPIRFLVVDLHHVA Ani PIQQRYLKEAGQQTLILKLGGYLFFGTIVDVENTMRGLIEDEAFSRLPIRFIILDLCRVY Yli ATQQKFLQECGNLIYLLKLSGYMFFGTIVRVEDTIKQ----------------------- Spo MNQQRFLNEIGRQIQVCKLSGFLFFGTINGVEKNIAGLIEELNVSNNPLRFLIIDFSLVN Bja RDDQEVLLAHGGKIQGLNLQSYLFFGSANRLYQHVKKLLHE----RPECRYLLFDFKLVT Sel ETQQSILRRRGAVLQVVSLQGYLFFGTARRIVSTVRDRLQQS---KVSINLVLLDYQAVT Lpn3 PISQSILSTQGDEIQFLKLQGFLFFGSIYRLLQLIKSIQKAR--------YIILDFELVY Pol FEESNLLTHSFNRVGILKLNGHLFFGNSIRLTQLVDELNPN-------AKAVVIDVSHVL . : .* . :***. : . : Kla IRAKSIDYSAAEGFNRIKRFLEK------------ Sce INADNIDYSAAEGFNRIKRFTETKRIKLIISSIKE Ego INIDNIDYSAAEGFNRIKRVMEIKRIKLIVSSISE Cne ----------------------------------- Uma ----------------------------------- Gze G----LDYSAGEAFNTISRLLDN------------ Ncr G----VDYSAGEVFNTISRLLNHKGIELIIS---- Mgr G----CDYSAGEAFGTL------------------ Ani G----VDFSAAEAFTRI------------------ Yli ----------------------------------- Spo G----ADFSVVQAFLRIRRMLA------------- Bja G----VDSSAAYSFAQI------------------ Sel G----ADSSTAEVFSRF------------------ Lpn3 N----IDSSRIILMKNL------------------ Pol D----VDPSGLNALTWL------------------