Fig. S3. CLUSTAL X (1.81) multiple sequence alignment Cte ------MLKPEFLSILKNEKGNLTKEGLIKDFIAGIIVAIIALPLSVALGIASG------ Bsu -------------MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASG------ Cca -MKVALSFKHLVPKLYTCIKDGYTFNTFKKDFLAGLTVGVLAFPFAIAIAIGVG------ Cpn -MKVPWAFKNFIPKLYTSIKEGYSFNTFKKDFQAGITVGILAFPFAIAIAIGVG------ Ctr MVKVSLSFKHLVPKLVTCLKEGYSFNTLKKDFTAGITAGILAFPLAIAIAIGIG------ Vpa -----------------MFGSRFKDINFKGDIFGGVTTAIISLPLALAFGVASG------ Vvu ----------------MMFGDRFNDINLKGDLFGGVTTAIISLPLALAFGVASG------ Vch -----------------MFQARFADLNLRCDLFGGVTTAIISLPLALAFGVASG------ Nos ----------------MSLTNTINFNNLRGDLFGGLTAAIVSLPLALAFGVASG------ Pma ----------------MEIINGFNLKNIRGDILGGITAAVVALPLALAFGNAALG----- Dar ------------------MQDVFKKLYQSGDFWGGLAAMLVALPAAIAFGVTIYSAIAPS Mma -------------------------MKFAGDAWGGLAAMLVALPSAIAFGVTIFAPLGGS * .*: . ::::* .:*:. Cte ---VSPEKGLITAIIAGFFISFLGGSRVQIGGPTGAFVVIIYGIIEKYGIDG-------- Bsu ---VEPEYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLEN-------- Cca ---VSPIQGLLASIIGGFIASALGGSRVLISGPTSAFISILYCISAKYGVEG-------- Cpn ---VSPIQGLLASIIGGLLASAMGGSNVLISGPSSAFISILYCLSAKYGAEA-------- Ctr ---VSPLQGLLASIIGGFLASALGGSRVLISGPTSSFISILYCIGVKYGEDG-------- Vpa ---AGAEAGLWGAIMVGLFASLFGGSNTLISEPTGPMTVIMTAVLTSMMAK------YPE Vvu ---AGAEAGLWGAILVGLFAALFGGSSTLISEPTGPMTVIMTAVLTSMVAK------YPE Vch ---AGAEAGLWGAILVGFFAALFGGSSTLISEPTGPMTVIMTAILTAMVAR------YPE Nos ---AGPVAGLYGAVCVGFFAALFGGTPTLISEPTGPMTVVMTAIVSSMTAS------NPE Pma --PGGAIYGLYGAVVVGFLAALFGGTPAQVSGPTGPMSVTVAGVVAGLAAVGVPRDLSAG Dar HAALGALAGIIGASVIGLIASTLGGTDRLISAPCAPAAALLSAFAIELVAQG----IPGG Mma LAAQGALAGILGATALGLLAPAFGSSARLISSPCAPAAAMLSALAVTFTKQG----LPAG . *: *: . :*.: :. * .. : . Cte -----LIVATLMAGIMLVIFGLLKFGSLIKYISYPITVGFTAGIAVTLFSTQVKDFLGLS Bsu -----LLIAGFMAGVMLVLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLR Cca -----LFTITLMGGVFLVAFGLTGLGTFIKYMPYPVVTGLTTGLAVIIFSSQIKDFFGLQ Cpn -----LFTVTLLAGVFLIAFGLTGLGTFIKYMPYPVVTGLTTGLAIIIFSSQIKDFLGLQ Ctr -----LFTITLMAGIFLIIFGLAGLGTFIKYMPYPVVTGLTTGIAVIIFSSQIRDFLGLQ Vpa TGMAMTFTVVMMAGAFQILLGTLKMGKYVTLMPYSVISGFMSGIGVILIILQLSPLLGHA Vvu SGIAISFTIVMMAGAFQVLIGTLKLGKYITLMPYSVVSGFMSGIGVILIILQLSPLLGHA Vch SGAAIAFTVVMMAGAFQILLGTLKLGKYITLMPYSVVSGFMSGIGVILIILQLSPLLGHP Nos NGLAMAFTVVMLAGLFQIFFGVFKLGKYITLMPYSVISGFMSGIGVILIILQIAPFVGQP Pma QILPLVMAAVVIGGLLQILFGILKLGKYITLVPYSVVSGFMSGIGVIIIALQIGPLLGIS Dar NIILLLLMLGVLAGMFQVLFGFVGIGRLIKYIPYPVVSGYLTGVGLIIIGSQIGKLLGTP Mma SVVLLLGLTAFLAGVFQIVLGLLRVGRLIKFIPYPVVCGYLSGVGLIIIGSQIPKLLGVP .:.* : : :* .* :. :. .: * :*:.: :: *: :.* Cte I-NKVPSEFLPKWSMYISNMGTINWVTLALGIFSLAVIIVWPKFNEKIPGALVALILSTF Bsu N-VEKHENFHHNMFEIVQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTV Cca MGDSVPTDFIAKWIAYWDYLWTWDSKAFAVGLFTLLIMIYFRNYKPRYPGVMIAIIVAST Cpn MGANIPADFLPKWIAYWDHLWTWDSKSFAVGLFTLLIMIYFRNYKPRYPGVMIAIVTATT Ctr MGDGVPLDFIGKWAAYWDYLWTWDSKTFAVGLFTLLLMIYFRNYKPRYPGVMISIIIAST Vpa APAGGVLGTLSALPETISNLKFNELFLGLLTLG--ILFFFPKKYRKYVPAQLVALVAVTL Vvu APAGGVLGTLSALPETISNMKFSEFFLGLLTLG--ILFFFPKQYRKYVPAQLVALVAVTL Vch SPGGGVLGTLSALPDLLANLKFSELFLGLLTLG--ILFFLPQKYRKQVPAQLVALVVVTL Nos SPKGGVLGMVQNLPILMTKINPAETILGVLTLA--IIFLMPSKIKRYAPPQLVALVVVTV Pma TRGGVVESLSTVFSNFQP--NGAAIGVAIMTLS--IVFLTPRKISQWVPSPLLALLIVTP Dar TGARWYEVLYTPSLWDWRALAVGLTTMLVMWLSPGLTRRLPATILGIAAGIACYFALASQ Mma GGVNLWAALSLPSLWAWQSITVGAVVMVVMVLTPRLTRAVPPAILALVAGLCAYFILAAF : . : : Cte IAYFFKLN-VATIGTQFGEISSKIPVPKLP------IVDIITLQKLIKPAFTIAILAAIE Bsu VAVVFFPDRMATIGSTYGEIPRHLPEFQFP------ELTLDKMVMLFPAALVIALLGGLE Cca LVWLLNID-IPTIGSRYGALPKSIPMPSFP------HLSLTKILQLMPEALTIAVLSGIE Cpn LVWLLKID-IPTIGSRYGTLPTAIPLPKIP------QLSITKILQLMPDALTIAVLSGLE Ctr LVWILKID-IPTIGSRYGTLPSSLPGPVFP------HISITKMLQLMPDALTISVLSGIE Vpa LSVMLFDT---EDIRRIGEIPAGLPSLVAP------HIDPDMFVEMVIDALVLGTLGCID Vvu LSVIIFDF---DDVRRIGEIPTGLPSLVVP------VINGEIFTAMVIDALVLGTLGCID Vch FSVIFFDT---DDIRRIGEIPAGLPSIVVP------TFTGDIVVTMVIDALVLGTLGCID Nos VSLVFFGN---VEIRRIGEIPMGLPQLRLP------TFNPSQITTMIIDGAMLGLLGCID Pma LSILIFGD---GALDRIGEIPRGVPSLSFP------SFN-QYFPIIFKAGLVLAVLGAID Dar DESLLQLAANNLVIGPLGASGEGYIQSITARWNEIGDLRLGQVAALLGNALTLAVLLSID Mma DADLLTIDGNPLLVGRITAGGFGVGATIGQQWRSLGALEPEILLEVIVPALTLAALLSID .: . . :. . :. * :: Cte SLLSAVVADGMIGEKHDSNMELVAQGVGNITSALFGGIPATGAIARTAANVKSGGRTPIA Bsu SILSAMVADNMKGSKHDSNKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVS Cca TLLAAVVADGMTGWRHQSNCQLVAQGIANIGTSFFAGMPITGSLSRTAASIKSGATTPIA Cpn TLLSAVVADGMTGWRHQSNCQLVAQGVANIGTSLFSGIPVTGSLSRTAASIKSEATTPIA Ctr TLLAAVVADGMTGWRHQSNCQLIGQGIANIGTSLFAGMPVTGSLSRTTASIKCGASTPIA Vpa TLLTAVIGDSLTRKEHDSDKELRGQGLANMISGLFGALPGAGATMGTVTNIQVGARSPLS Vvu TLLTAVIGDSLTRKEHDSDKELRGQGFANMISGLFGALPGAGATMGTVTNIQVGARSPLS Vch TLLTAVIGDSLTRKEHDSDRELQGQGIANMVAGLFGALPGAGATMGTVTNIQVGARSPLS Nos TLLTAVIADSLTRTEHKSDKELIGQGIANFVSGLCGGLPGAGATMGTVVNIQTGARTAVS Pma SLLTSLVADNISQTRHNSDRELIGQGIGNAIAGLFSGLPGAGATMRTVINVKSGGSTPIS Dar TLKTCVVLDQLTRSQHNPNRELVAQGIANIASSSVGGIPGAGTMGATLVNLSSGAMTRAS Mma TLKTCVVLDAMTNSDSNPNRDLLGQGIGNVASALVGGVPGAGTMGASLINVNSGANSRVS :: :.:: * : ..: :* .**..* : ..:* :*: : .:. . : : Cte GMVHAITLLLIMKVLMPLAKYIPLTTLAAVLIVVSYNMSGWRTFRDMLR-APKSDVLILL Bsu GVVHGVVVLLVLLVFAPYASHVPLASMAPILMVVAWNMSERKEVANMLR-LKNADSFILA Cca GLVHSAFICVILLALAPLTVKIPLTCLAAVLILIAWNMSEIHHFIHLFT-APKKDVVVLL Cpn GIVHSIFICFILLLLAPLTVKIPLTCLAAVLILIAWNMSEIHHFIHLFT-APKKDIVVLL Ctr GIIHAICLSFILLLLAPLTIKIPLTCLAAVLILIAWNMSEIHHFIHLFT-APKKDVVVLL Vpa GVVRALVLALVVLVAGGLTEPIPMAVLAGIAVYVGFNILDWSFIQRAHK-VSFSGMAIMY Vvu GVIRALILALVVLVASGLTEPIPMAVLAGIAVYVGFGILDWSFIQRAHR-VSVQGMAIMY Vch GVTRALMLALVVLVAGGLTEPIPMAVLAGIAVYVGVNILDWAFIQRAHK-ISLQGMAIMY Nos GITRALILLVVVLWAANITETIPMAVLAGIALKVGIDILDWSFLKRAHK-VSLKGTIIMY Pma GMVHSVVLLIVLVGAGPLAEQIPTALLAGILIKVGLDIIDWGFLRRAHK-LSLKTAVVMY Dar GLVEGISALVFALLLSSFIAWIPVAALAGILIVVGIRMIDRGPLRFVQSSATVFDFGVVV Mma GLLAGALCFVAFLVLSPVIAWVPVSAPGLHPDRHRLSHDRPAFLAFFYTPATRLDFLVIT *: . . :* : . . :: Cte ATFFITVIFDLVIAIEVGIIISMCLFMRRMAL------AIEVNE------LDGSYCSKK- Bsu ATFALTVLFDLIIGVATGLLLAFVFFIRRMSE------ATRIHN------QETHPVLAK- Cca TVFILTVMTNITSAVQVGMMLAAFLFMKQMSD------LSDVIS------TAKYFDENKQ Cpn TVFILTVMTTITAAVQVGMMLAAFLFMKQMSD------LSDVIS------TAKYFD---- Ctr TVFILTVMTTITSAVQVGMMLAAFLFMKQMSD------LSDVIS------TAKYFDESEQ Vpa GVMLLTVFVDLIVAVGLGVFVSNIMIIERLSR------EQAR----QVKAISDADEDDVP Vvu GVMLLTVFVDLIVAVGLGVFISNILIIERLSR------EQAK----QVKAISDADENDVP Vch GVMLLTVFVDLIVAVGLGVFISNILVIERLSR------EQAR----QVKAISDADDDDVP Nos GVLFLTVFVDLIVAVGVGVFIANILTIERLSE------LQSQ----DVKTISDTD-DAIV Pma GVLLMTVFWDLIWAVLVGVFIANMLTIDSITE------TQLEGMDQDNPLSEDNEQSKNL Dar TVVVVALTIGLIAASATGVALSIILFLREQIGGSVVRH----------KFYVNQMSSSWH Mma AVIVVALFVNLIAASGVGVAFAILLFIREQTRSTVVRN----------RIDGNHLFSKRQ .. ::: : . *: .: : : Cte -LRLEGIHTNKIGDEILIYDIKGPLFFAGIDSFIS-SIESLNTESKVVILRMKNMPVLDV Bsu -REDP---------SVSMYAIEGPLFFGSIDSLESSLLEHVQKKPKTLILLMNKVHYMDT Cca AKDDNFFSKSEVPAHTEIYEINGPFFFGIADRLKN-LLNEIEMPPKIFILCMSRVPTIDA Cpn -KDSDFLSKAEVPQNTEIYEINGPFFFGIADRLKN-LLNDIEKPPKIFILCMTRVPTIDA Ctr PQNDLLFSKNEVPPFTEIYEINGPFFFGIADRLKN-LLNEIEKPPKIFILCMTRVPTIDA Vpa LTDSERGLLDRANGRVLFFYLSGPMIFSVSKAISR--QHTSISDYDVMILDLTDVPMLDV Vvu LTDSERGLLDRANGKVLFFYLSGPMIFSVSKAISR--QHSSISDYEAMILDLTDVPMIDV Vch LTESERKLLDKANGKVLFFYLSGPMIFSVSKAITR--QHSSVDQYQAMILDLTDVPMIDV Nos LSDEEKGLLDQANGRILLFYLSGPMIFGVSKAIAR--EHTAMADSDVLIVDLSDVPMLGI Pma LPSDEKALLDRCSGEVMLFRLKGPLSFGAAKGITE--RMMLVRNYKILILDITDVPRVGV Dar RPEAETRILEKKGDQAVIFELQGSLFFGTTQQLYS-QLEPELKSRNFVILDMKRIQSVDV Mma RAAGEAEVAAEGPSDTVVFELQGSLFFGTASQLHA-ALEPETRSRKFVILSMRRVQSLDL .: :.*.: *. . : . .*: : : :. Cte TAYGELKKIEKLCMDEEIKLIMSEVQKQPMKVMKNMGMVSRLGERRFIKTLEEAIRTANN Bsu SAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLHKTGLFHKIGKQHFFDHHDEITG---- Cca SAMHALEEFFLECDRQGTLLLLAGVKKTPLSDLKRYHLDELIGVDHIFSNTKSALLFAQA Cpn SAMHALEEFFLECDRQGTLLLLAGVKKTPLADLKRYHLDELIGVDHIFSNIKSALLFAQA Ctr SAMHALEEFFLECDRQGTLLLLAGVKKTPLSDLRRYHVDELIGVDHIFPNIKGALLFAKA Vpa TVGLALENAIKDALDARCEVYLLCPNQRTREQLEKFHVIDLVPDNNMYQFRYEALNAAVA Vvu TVGLALENAIKDAQEAQCDVYLLCPNERVREQLEKFHVLDLVPDENTFKFRYEALNAAVN Vch TVGLALENAIRDAQEAHCEVYLLCPNEKTRAELEKFKVIDLVPDQNMFTFRYEALNAAVK Nos TASLAIENAIKDASEQGRQVLIVGAAGKVKRRLEKFGIMRFVPAHYMFVDRVEALKQGVA Pma TATLAIEDMMQEAKNNSRKAFVAGANEKVKERLSKFGVDGIIET------RKEALEAALN Dar TAAHLLSQV--------------------------------------------------- Mma TATHVLEQI--------------------------------------------------- :. : . Cte CCID------------------------- Bsu ----------------------------- Cca LINLESKASH------------------- Cpn LTNLESKTSTRHLV--------------- Ctr LIKLESKSSQ------------------- Vpa HVESDQYQRMTA----------------- Vvu KVEQDEHQGAFV----------------- Vch QVNT------------------------- Nos IVKSNGTGATGVNALTNQGNDPDSYAYPN Pma ELA-------------------------- Dar ----------------------------- Mma -----------------------------